Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Scott J. Toth"'
Publikováno v:
AIChE Journal. 61:4502-4508
Solid dispersions have been used to enhance the bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs). However, the solid state phase, compositional uniformity, and scale-up problems are issues that need to be addressed. To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2c3053f2582f8669c81b27407c9c555
https://doi.org/10.1002/aic.14979
https://doi.org/10.1002/aic.14979
Autor:
Irene A. George, Lynne S. Taylor, Niraj S. Trasi, Shane Z. Sullivan, Scott J. Toth, Greg R. Snyder, Garth J. Simpson, Paul D. Schmitt
Publikováno v:
Crystal Growth & Design. 15:581-586
A model for predicting the anticipated second harmonic generation (SHG) activity of crystalline active pharmaceutical ingredients (APIs) was developed based on combining time-dependent Hartree–Fock calculations of the molecular building block with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5944c1a1629f114c9727d827a65a70e
https://doi.org/10.1021/acs.cgd.5b00020
https://doi.org/10.1021/acs.cgd.5b00020
Autor:
Scott J. Toth, Garth J. Simpson, Matthew J. Jackson, Munir A. Hussain, Jun Huang, Feng Qian, Umesh S. Kestur, Lynne S. Taylor
Publikováno v:
Molecular Pharmaceutics. 11:3027-3038
The phase behavior of supersaturated solutions of a relatively hydrophobic drug, danazol, was studied in the absence and presence of polymeric additives. To differentiate between phase separation to a noncrystalline phase and phase separation to a cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b448f01664f2bc75b747999e9e169dae
https://doi.org/10.1021/mp500201s
https://doi.org/10.1021/mp500201s
Autor:
Dale Ferguson, Judith A. Ronau, Vadim Cherezov, Hartmut G. Hedderich, Garth J. Simpson, Jeremy T. Madden, Robert Aaron Oglesbee, Oleg Makarov, Susan K. Buchanan, R.M. Everly, Chittaranjan Das, S. Xu, Christopher M. Dettmar, Robert F. Fischetti, Michael Becker, Marie E. Morrow, Justin A. Newman, Scott J. Toth
Publikováno v:
Journal of Synchrotron Radiation
Nonlinear optical (NLO) instrumentation has been integrated with synchrotron X-ray diffraction for combined single-platform analysis, examining the viability of NLO microscopy as an alternative to the conventional X-ray raster scan for the purposes o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::891e8395a4c08da7e31878e04797676b
https://doi.org/10.1107/s0909049513007942
https://doi.org/10.1107/s0909049513007942
Publikováno v:
The Journal of Physical Chemistry B. 117:1494-1500
The crystallization kinetics of naproxen (NAP) in NAP/polyethylene glycol (NAP/PEG) solid dispersions prepared at different crystallization temperatures was studied by in situ small-angle X-ray scattering/wide-angle X-ray scattering (SAXS/WAXS). It w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5135c32b5a479208e46a5ec89820731e
https://doi.org/10.1021/jp3106716
https://doi.org/10.1021/jp3106716
Publikováno v:
Analytical Chemistry. 84:5869-5875
Second order nonlinear optical imaging of chiral crystals (SONICC) and two-photon excited fluorescence measurements [both autofluorescence and two-photon excited UV-fluorescence (TPE-UVF)] were assessed for the selective detection of APIs relative to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::686fe008975431fd719ca67b5bac4800
https://doi.org/10.1021/ac300917t
https://doi.org/10.1021/ac300917t
Autor:
Scott J. Toth, Paul D. Schmitt, Shijie Zhang, Garth J. Simpson, Fengyuan Deng, Justin A. Newman
Publikováno v:
Analytical chemistry. 87(21)
Here we demonstrate the use of second harmonic generation (SHG) microscopy-guided synchrotron powder X-ray diffraction (PXRD) for the detection of trace crystalline active pharmaceutical ingredients in a common polymer blend. The combined instrument
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b9d7539dd5452da217741a1e740c0b8
https://pubmed.ncbi.nlm.nih.gov/26465382
https://pubmed.ncbi.nlm.nih.gov/26465382
Autor:
Ryan D. Muir, Garth J. Simpson, Scott J. Toth, Kevin P. Battaile, Nicholas Roman Pogranichniy, Anne M. Mulichak, Shane Z. Sullivan, J. Lewis Muir, Lisa J. Keefe
Publikováno v:
Computational Imaging
Pixel-array array detectors allow single-photon counting to be performed on a massively parallel scale, with several million counting circuits and detectors in the array. Because the number of photoelectrons produced at the detector surface depends o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9ffe59c802e6cba2ed1c06f240d8e48
https://doi.org/10.1117/12.2079548
https://doi.org/10.1117/12.2079548
Autor:
Justin A. Newman, Scott J. Toth, Christopher M. Dettmar, Michael Becker, Robert F. Fischetti, Garth J. Simpson
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 112(3)
Electron-hole separation following hard X-ray absorption during diffraction analysis of soft materials under cryogenic conditions produces substantial local electric fields visualizable by second harmonic generation (SHG) microscopy. Monte Carlo simu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ce5406d297c1067fca3970c2b1797fd
https://pubmed.ncbi.nlm.nih.gov/25552555
https://pubmed.ncbi.nlm.nih.gov/25552555
Amorphous and crystalline solids are commonly found together in a variety of pharmaceutical and food products. In this study, the influence of co-formulation of amorphous maltodextrins (MDs) and crystalline sucrose (S) on moisture sorption, deliquesc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::813eecbcdda72935063adfb2ce5c8369
https://europepmc.org/articles/PMC4755289/
https://europepmc.org/articles/PMC4755289/
