Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Scott J. O'Neill"'
Autor:
William Pendergast, Kwen-Jen Chang, Garrett J. Gross, Ke Wei, Scott J. O'Neill, Jonathon D. S. Holt, Peter J. Gengo, Michael. J. Watson
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 316:423-430
A novel delta-receptor selective compound, ARD-353 [4-((2R,5S)-4-(R)-(4-diethylcarbamoylphenyl)(3-hydroxyphenyl)methyl)-2, 5-dimethylpiperazin-1-ylmethyl)benzoic acid], was evaluated for activity on infarct size in a rat model of acute myocardial inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa3f750a3e67d899e4bcf6aea8f4ceb2
https://doi.org/10.1124/jpet.105.092742
https://doi.org/10.1124/jpet.105.092742
Autor:
Peter J. Gengo, Robert W. McNutt, Ying Fu Su, Kwen-Jen Chang, Hugh O. Pettit, Scott J. O'Neill
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 307:1227-1233
Allyl-2,5-dimethyl-1-piperazines have been of interest as analgesic agents for the management of moderate-to-severe pain. In this study, we compared the antinociceptive properties and respiratory depressant activity of one such agent, (+)-3-((alpha-R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a88fbd2a53724680e810e75fe15985e
https://doi.org/10.1124/jpet.103.054429
https://doi.org/10.1124/jpet.103.054429
Autor:
G. Evan Boswell, Kwen-Jen Chang, Mark A. Collins, Ke Wei, Dulce Garrido, Philip A. Harris, Michael J. Bishop, Robert W. McNutt, Scott J. O'Neill
Publikováno v:
Journal of Medicinal Chemistry. 46:623-633
Opioid analgesics with both micro and delta opioid receptor activation represent a new approach to the treatment of severe pain with an improved safety profile. Compounds with this profile may exhibit strong analgesic properties due to micro agonism,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e846a0a594b9733650e9099224a29f7
https://doi.org/10.1021/jm020395s
https://doi.org/10.1021/jm020395s
Autor:
William Pendergast, Ke Wei, Michael. J. Watson, Jonathon D.S. Holt, Scott J. O'Neill, Peter J. Gengo, Kwen-Jen Chang, Jane P. Chang
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 315(2)
There is a wealth of information from animal models and clinical opioid-analgesic use that indicates a significant role for opioid receptors in the modulation of bladder activity. The novel benzhydrylpiperazine compound DPI-221 [4-((alpha-S)-alpha-((
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63c1bfae6beb88a656f4f818efe7f202
https://pubmed.ncbi.nlm.nih.gov/16020629
https://pubmed.ncbi.nlm.nih.gov/16020629
Autor:
Scott J. O'Neill, Peter J. Gengo, Ke Wei, Michael J. Bishop, Robert W. McNutt, Kwen-Jen Chang, Hugh O. Pettit
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 307(3)
Compound (+)-3-((alpha-R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-(3-fluorophenyl)-N-methylbenzamide (DPI-3290), is one of a series of novel centrally acting agents with potent antinociceptive activity that binds specifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::627cb28e68af9c755395d87c58883e34
https://pubmed.ncbi.nlm.nih.gov/14534368
https://pubmed.ncbi.nlm.nih.gov/14534368
Autor:
Peter J, Gengo, Hugh O, Pettit, Scott J, O'Neill, Ying Fu, Su, Robert, McNutt, Kwen-Jen, Chang
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 307(3)
Allyl-2,5-dimethyl-1-piperazines have been of interest as analgesic agents for the management of moderate-to-severe pain. In this study, we compared the antinociceptive properties and respiratory depressant activity of one such agent, (+)-3-((alpha-R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e3a01deddca8bf732c64bae1ae0a9aea
https://pubmed.ncbi.nlm.nih.gov/14534367
https://pubmed.ncbi.nlm.nih.gov/14534367