Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Scott J. Lusher"'
Autor:
Sebastiaan L. Knijnenburg, Renger H. Jellema, Christine Kirkpatrick, Luiz Olavo Bonino da Silva Santos, Jean-Marc Neefs, Albert Mons, Martijn G. Kersloot, Gerbrand Ruiter, Wouter Franke, Herman van Vlijmen, Derk L. Arts, Bert Meerman, Scott J. Lusher, Arie Baak, Arne Waalkens, Rudi Verbeeck
Publikováno v:
Data Intelligence, 2(1-2), 276-284. MIT Press Journals
The industry sector is a very large producer and consumer of data, and many companies traditionally focused on production or manufacturing are now relying on the analysis of large amounts of data to develop new products and services. As many of the d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4d7a64965909698e930529aef78e255
https://pure.amc.nl/en/publications/the-need-of-industry-to-go-fair(4d3962d4-a8a5-46e6-a134-5d6fca3bbb01).html
https://pure.amc.nl/en/publications/the-need-of-industry-to-go-fair(4d3962d4-a8a5-46e6-a134-5d6fca3bbb01).html
Autor:
Marie-José C van Lierop, Wynand Alkema, Anke J Laskewitz, Rein Dijkema, Hans M van der Maaden, Martin J Smit, Ralf Plate, Paolo G M Conti, Christan G J M Jans, C Marco Timmers, Constant A A van Boeckel, Scott J Lusher, Ross McGuire, Rene C van Schaik, Jacob de Vlieg, Ruben L Smeets, Claudia L Hofstra, Annemieke M H Boots, Marcel van Duin, Benno A Ingelse, Willem G E J Schoonen, Aldo Grefhorst, Theo H van Dijk, Folkert Kuipers, Wim H A Dokter
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e48385 (2012)
Glucocorticoids (GCs) such as prednisolone are potent immunosuppressive drugs but suffer from severe adverse effects, including the induction of insulin resistance. Therefore, development of so-called Selective Glucocorticoid Receptor Modulators (SGR
Externí odkaz:
https://doaj.org/article/6e9843e211b74a5b893e7e79339992e9
Autor:
Chris T. Evelo, Gabrielle Appleton, Maryann E. Martone, Philip E. Bourne, Johan van der Lei, Jaap Heringa, Michel Dumontier, Erik Anthony Schultes, Luiz Olavo Bonino da Silva Santos, Paul Groth, Alejandra Gonzalez-Beltran, Abel L. Packer, Morris A. Swertz, Jun Zhao, Myles Axton, Jan Willem Boiten, Carole Goble, Bengt Persson, Ingrid Dillo, Philippe Rocca-Serra, Rene van Schaik, Mark Thompson, Jeffrey S. Grethe, Jan Velterop, Barend Mons, Tobias Kuhn, Rob Hooft, Scott J. Lusher, Scott C. Edmunds, Ted Slater, Alasdair J. G. Gray, Joost N. Kok, IJsbrand Jan Aalbersberg, Erik M. van Mulligen, Anthony J. Brookes, Arie Baak, Olivier G. Dumon, Albert Mons, Ruben Kok, Susanna-Assunta Sansone, George Strawn, Marco Roos, Timothy Clark, Richard Finkers, Peter Wittenburg, Mark Wilkinson, Jildau Bouwman, Katherine Wolstencroft, Peter A C 't Hoen, Mercè Crosas, Niklas Blomberg, Thierry Sengstag, Andra Waagmeester
Publikováno v:
Wilkinson, M D, Dumontier, M, Jan Aalbersberg, I, Appleton, G, Axton, M, Baak, A, Blomberg, N, Boiten, J W, da Silva Santos, L B, Bourne, P E, Bouwman, J, Brookes, A J, Clark, T, Crosas, M, Dillo, I, Dumon, O, Edmunds, S, Evelo, C T, Finkers, R, Gonzalez-Beltran, A, Gray, A J G, Groth, P, Goble, C, Grethe, J S, Heringa, J, Hoen, P A C T, Hooft, R, Kuhn, T, Kok, R, Kok, J, Lusher, S J, Martone, M E, Mons, A, Packer, A L, Persson, B, Rocca-Serra, P, Roos, M, van Schaik, R, Sansone, S A, Schultes, E, Sengstag, T, Slater, T, Strawn, G, Swertz, M A, Thompson, M, van der Lei, J, van Mulligen, E, Jan Velterop, V, Waagmeester, A, Wittenburg, P, Wolstencroft, K, Zhao, J & Mons, B 2019, ' Addendum: The FAIR Guiding Principles for scientific data management and stewardship ', Scientific Data, vol. 6, 6, pp. 1-1 . https://doi.org/10.1038/s41597-019-0009-6
Scientific Data, 6
Scientific Data
Scientific Data 6 (2019)
Scientific Data, Vol 6, Iss 1, Pp 1-2 (2019)
Scientific Data, 1, 6, 6
Scientific Data, 6
Scientific Data
Scientific Data 6 (2019)
Scientific Data, Vol 6, Iss 1, Pp 1-2 (2019)
Scientific Data, 1, 6, 6
There is an urgent need to improve the infrastructure supporting the reuse of scholarly data. A diverse set of stakeholders-representing academia, industry, funding agencies, and scholarly publishers-have come together to design and jointly endorse a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::597a4997a3955da723bf5d574360a7df
https://hdl.handle.net/1871.1/4f7f4517-e20c-44f8-8aea-e40611e9883f
https://hdl.handle.net/1871.1/4f7f4517-e20c-44f8-8aea-e40611e9883f
Autor:
Scott J. Lusher, Tina Ritschel
Publikováno v:
Future Medicinal Chemistry, 7, 1213-6
Future Medicinal Chemistry, 7, 10, pp. 1213-6
Future Medicinal Chemistry, 7, 10, pp. 1213-6
Data generation in pharmaceutical research has been industrialized without our capacity to manage, disseminate, analyze and base decisions upon these data keeping pace. Like most scientific disciplines, medicinal chemistry is becoming increasingly da
Autor:
Albert J. Kooistra, Lars Ridder, Stefan Verhoeven, Rob Leurs, Ross McGuire, Chris de Graaf, Scott J. Lusher, Gerrit Vriend, Tina Ritschel, Iwan J. P. de Esch, Márton Vass
Publikováno v:
Journal of Chemical Information and Modeling, 57(2), 115-121. American Chemical Society
Europe PubMed Central
McGuire, R, Verhoeven, S, Vass, M, Vriend, G, De Esch, I J P, Lusher, S J, Leurs, R, Ridder, L, Kooistra, A J, Ritschel, T & de Graaf, C 2017, ' 3D-e-Chem-VM : Structural Cheminformatics Research Infrastructure in a Freely Available Virtual Machine ', Journal of Chemical Information and Modeling, vol. 57, no. 2, pp. 115-121 . https://doi.org/10.1021/acs.jcim.6b00686
Journal of Chemical Information and Modeling
Journal of Chemical Information and Modeling, 57, 2, pp. 115-121
Journal of Chemical Information and Modeling, 57, 115-121
Europe PubMed Central
McGuire, R, Verhoeven, S, Vass, M, Vriend, G, De Esch, I J P, Lusher, S J, Leurs, R, Ridder, L, Kooistra, A J, Ritschel, T & de Graaf, C 2017, ' 3D-e-Chem-VM : Structural Cheminformatics Research Infrastructure in a Freely Available Virtual Machine ', Journal of Chemical Information and Modeling, vol. 57, no. 2, pp. 115-121 . https://doi.org/10.1021/acs.jcim.6b00686
Journal of Chemical Information and Modeling
Journal of Chemical Information and Modeling, 57, 2, pp. 115-121
Journal of Chemical Information and Modeling, 57, 115-121
Contains fulltext : 169642.pdf (Publisher’s version ) (Open Access) 3D-e-Chem-VM is an open source, freely available Virtual Machine ( http://3d-e-chem.github.io/3D-e-Chem-VM/ ) that integrates cheminformatics and bioinformatics tools for the analy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72cdb23a815ed0bd9dea612f63b6eee3
https://research.vu.nl/en/publications/34968b16-6a31-4fd8-b49d-152f1c4fc880
https://research.vu.nl/en/publications/34968b16-6a31-4fd8-b49d-152f1c4fc880
Autor:
Mark D. Wilkinson, Michel Dumontier, IJsbrand Jan Aalbersberg, Gabrielle Appleton, Myles Axton, Arie Baak, Niklas Blomberg, Jan-Willem Boiten, Luiz Bonino da Silva Santos, Philip E. Bourne, Jildau Bouwman, Anthony J. Brookes, Tim Clark, Mercè Crosas, Ingrid Dillo, Olivier Dumon, Scott Edmunds, Chris T. Evelo, Richard Finkers, Alejandra Gonzalez-Beltran, Alasdair J.G. Gray, Paul Groth, Carole Goble, Jeffrey S. Grethe, Jaap Heringa, Peter A.C ’t Hoen, Rob Hooft, Tobias Kuhn, Ruben Kok, Joost Kok, Scott J. Lusher, Maryann E. Martone, Albert Mons, Abel L. Packer, Bengt Persson, Philippe Rocca-Serra, Marco Roos, Rene van Schaik, Susanna-Assunta Sansone, Erik Schultes, Thierry Sengstag, Ted Slater, George Strawn, Morris A. Swertz, Mark Thompson, Johan van der Lei, Erik van Mulligen, Jan Velterop, Andra Waagmeester, Peter Wittenburg, Katherine Wolstencroft, Jun Zhao, Barend Mons
Publikováno v:
Scientific Data, 3:160018. Nature Publishing Group
Scientific Data, 3
Wilkinson, M D, Dumontier, M, Aalbersberg, IJ J, Appleton, G, Axton, M, Baak, A, Blomberg, N, Boiten, J W, da Silva Santos, L B, Bourne, P E, Bouwman, J, Brookes, A J, Clark, T, Crosas, M, Dillo, I, Dumon, O, Edmunds, S, Evelo, C T, Finkers, R, Gonzalez-Beltran, A, Gray, A J G, Groth, P, Goble, C, Grethe, J S, Heringa, J, 't Hoen, P A C, Hooft, R, Kuhn, T, Kok, R, Kok, J, Lusher, S J, Martone, M E, Mons, A, Packer, A L, Persson, B, Rocca-Serra, P, Roos, M, van Schaik, R, Sansone, S A, Schultes, E, Sengstag, T, Slater, T, Strawn, G, Swertz, M A, Thompson, M, Van Der Lei, J, Van Mulligen, E, Velterop, J, Waagmeester, A, Wittenburg, P, Wolstencroft, K, Zhao, J & Mons, B 2016, ' The FAIR Guiding Principles for scientific data management and stewardship ', Scientific Data, vol. 3, 160018 . https://doi.org/10.1038/sdata.2016.18
Sci Data
Scientific Data, 2016(3), 160018
Scientific Data, ISSN 2052-4463, 2016, Vol. 3
Archivo Digital UPM
Universidad Politécnica de Madrid
Wilkinson, M D, Dumontier, M, Aalbersberg, IJ J, Appleton, G, Axton, M, Baak, A, Blomberg, N, Boiten, J-W, da Silva Santos, L B, Bourne, P E, Bouwman, J, Brookes, A J, Clark, T, Crosas, M, Dillo, I, Dumon, O, Edmunds, S, Evelo, C T, Finkers, R, Gonzalez-Beltran, A, Gray, A J G, Groth, P T, Goble, C, Grethe, J S, Heringa, J, ’t Hoen, P A C, Hooft, R, Kuhn, T, Kok, R, Kok, J, Lusher, S J, Martone, M E, Mons, A, Packer, A L, Persson, B, Rocca-Serra, P, Roos, M, van Schaik, R, Sansone, S-A, Schultes, E, Sengstag, T, Slater, T, Strawn, G, Swertz, M A, Thompson, M, van der Lei, J, van Mulligen, E, Velterop, J, Waagmeester, A, Wittenburg, P, Wolstencroft, K, Zhao, J & Mons, B 2016, ' The FAIR Guiding Principles for scientific data management and stewardship ', Scientific Data, vol. 3, 160018 . https://doi.org/10.1038/sdata.2016.18
Nature, 3. Nature Publishing Group
Scientific Data
Scientific data, 3:160018. Nature Publishing Group
Scientific data, vol 3, iss 1
Scientific Data 3 (2016)
Scientific data, 3:Unsp 160018. Nature Publishing Group
Scientific Data, 3
Wilkinson, M D, Dumontier, M, Aalbersberg, IJ J, Appleton, G, Axton, M, Baak, A, Blomberg, N, Boiten, J W, da Silva Santos, L B, Bourne, P E, Bouwman, J, Brookes, A J, Clark, T, Crosas, M, Dillo, I, Dumon, O, Edmunds, S, Evelo, C T, Finkers, R, Gonzalez-Beltran, A, Gray, A J G, Groth, P, Goble, C, Grethe, J S, Heringa, J, 't Hoen, P A C, Hooft, R, Kuhn, T, Kok, R, Kok, J, Lusher, S J, Martone, M E, Mons, A, Packer, A L, Persson, B, Rocca-Serra, P, Roos, M, van Schaik, R, Sansone, S A, Schultes, E, Sengstag, T, Slater, T, Strawn, G, Swertz, M A, Thompson, M, Van Der Lei, J, Van Mulligen, E, Velterop, J, Waagmeester, A, Wittenburg, P, Wolstencroft, K, Zhao, J & Mons, B 2016, ' The FAIR Guiding Principles for scientific data management and stewardship ', Scientific Data, vol. 3, 160018 . https://doi.org/10.1038/sdata.2016.18
Sci Data
Scientific Data, 2016(3), 160018
Scientific Data, ISSN 2052-4463, 2016, Vol. 3
Archivo Digital UPM
Universidad Politécnica de Madrid
Wilkinson, M D, Dumontier, M, Aalbersberg, IJ J, Appleton, G, Axton, M, Baak, A, Blomberg, N, Boiten, J-W, da Silva Santos, L B, Bourne, P E, Bouwman, J, Brookes, A J, Clark, T, Crosas, M, Dillo, I, Dumon, O, Edmunds, S, Evelo, C T, Finkers, R, Gonzalez-Beltran, A, Gray, A J G, Groth, P T, Goble, C, Grethe, J S, Heringa, J, ’t Hoen, P A C, Hooft, R, Kuhn, T, Kok, R, Kok, J, Lusher, S J, Martone, M E, Mons, A, Packer, A L, Persson, B, Rocca-Serra, P, Roos, M, van Schaik, R, Sansone, S-A, Schultes, E, Sengstag, T, Slater, T, Strawn, G, Swertz, M A, Thompson, M, van der Lei, J, van Mulligen, E, Velterop, J, Waagmeester, A, Wittenburg, P, Wolstencroft, K, Zhao, J & Mons, B 2016, ' The FAIR Guiding Principles for scientific data management and stewardship ', Scientific Data, vol. 3, 160018 . https://doi.org/10.1038/sdata.2016.18
Nature, 3. Nature Publishing Group
Scientific Data
Scientific data, 3:160018. Nature Publishing Group
Scientific data, vol 3, iss 1
Scientific Data 3 (2016)
Scientific data, 3:Unsp 160018. Nature Publishing Group
Managing paleoscience data is highly challenging to the multiplicity of actors in play, types of sampling, analysis, post-analysis treatments, statistics etc. However, a well-structured curating of data would permit innovative developments based on d
Autor:
Marcel van Duin, Rita Azevedo, Hans Hamersma, Diep Vu-Pham, Arthur Oubrie, Scott J. Lusher, Rolien Bosch, Bert Kazemier, Hans C.A. Raaijmakers, Jacob de Vlieg, Koen J. Dechering, Ross McGuire
Publikováno v:
Journal of Biological Chemistry, 287, 20333-20343
Journal of Biological Chemistry, 287, 24, pp. 20333-20343
Journal of Biological Chemistry, 287, 24, pp. 20333-20343
Contains fulltext : 103894.pdf (Publisher’s version ) (Open Access) We present here the x-ray structures of the progesterone receptor (PR) in complex with two mixed profile PR modulators whose functional activity results from two differing molecula
Autor:
Ross McGuire, Rolien Bosch, Jacob de Vlieg, Niall M. Hamilton, Olaf Nimz, Koen J. Dechering, Angus R. Brown, Scott J. Lusher, Tsang Wai Lam, Arthur Oubrie, Diep Vu-Pham, Hans C.A. Raaijmakers
Publikováno v:
Journal of Biological Chemistry, 286, 35079-35086
Journal of Biological Chemistry, 286, 40, pp. 35079-35086
Journal of Biological Chemistry, 286, 40, pp. 35079-35086
The progesterone receptor is able to bind to a large number and variety of ligands that elicit a broad range of transcriptional responses ranging from full agonism to full antagonism and numerous mixed profiles inbetween. We describe here two new pro
Autor:
Scott J. Lusher, René C. van Schaik, Jacob de Vlieg, Jan-Willem Boiten, Ross McGuire, Rita Azevedo
Publikováno v:
Drug Discovery Today, 16(13-14), 555-568. Elsevier
Drug Discovery Today, 16, 13-14, pp. 555-568
Drug Discovery Today, 16, 555-568
Drug Discovery Today, 16, 13-14, pp. 555-568
Drug Discovery Today, 16, 555-568
The difference between biologically active molecules and drugs is that the latter balance an array of related and unrelated properties required for administration to patients. Inevitability, during optimization, some of these multiple factors will co
Autor:
Richard Goodwin, Fiona Thomson, John W. Clark, Brad Sherborne, Lynn Watson, Angus R. Brown, Morag Grassie, Jack Pick, Angela Cowley, Olaf Nimz, J. Richard Morphy, Lorraine McIntosh, Niall M. Hamilton, Littlewood Peter Thomas Albert, Alasdair Smith, Koc-Kan Ho, Michael Speake, Alison Hillier, Ashvin Mistry, Michael Bosies, Simon James Anthony Grove, Mark Craighead, Theresa McIntyre, Michael Kiczun, Grant Emma Jane, Moira A. Elmore, Hannah Hampson, Mark Weston, Susan MacDonald, Susan Goutcher, Scott J. Lusher, Gayle Spinks, Zoran Rankovic, Michael Ohlmeyer, Helen Cameron, Alistair Firth, Steven G. Kultgen, Celia Kingsbury
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:137-140
High-throughput screening of 3.87 million compounds delivered a novel series of non-steroidal GR antagonists. Subsequent rounds of optimisation allowed progression from a non-selective ligand with a poor ADMET profile to an orally bioavailable, selec