Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Scott J. Hayton"'
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23885 (2011)
Impulse control is an executive process that allows animals to inhibit their actions until an appropriate time. Previously, we reported that learning a simple response inhibition task increases AMPA currents at excitatory synapses in the prelimbic re
Externí odkaz:
https://doaj.org/article/694540900e5b489899f78f23e4f73188
Autor:
Luis de Lecea, Robert C. Malenka, Scott J. Hayton, Keith R. Murphy, Peng Li, Andrew J. Whittle, Clara Touriño, Shi-Bin Li
Publikováno v:
SSRN Electronic Journal.
SummaryIn response to hypoxic threat, animals experience aversive feelings to engage behaviors which aid in restoring physiological balance. However, the pathways that connect interoception of tissue-oxygenation to the emotional brain remain largely
Autor:
Catherine P Normandeau, Andrea A. Jones, Cynthia Di Prospero, Eric Dumont, Julian deBacker, Elysia Mechefske, Scott J. Hayton, Emily R. Hawken, James Gardner Gregory
Publikováno v:
Neuropsychopharmacology. 40:394-405
Drugs of abuse have detrimental effects on homeostatic synaptic plasticity in the motivational brain network. Bidirectional plasticity at excitatory synapses helps keep neural circuits within a functional range to allow for behavioral flexibility. Th
Autor:
Scott J. Hayton, Stephan Maxeiner, Thomas C. Südhof, Byung Kook Lim, Stephen C. Fowler, Marc V. Fuccillo, Ozgun Gokce, Robert C. Malenka, Patrick E. Rothwell
Publikováno v:
Cell. 158:198-212
SummaryIn humans, neuroligin-3 mutations are associated with autism, whereas in mice, the corresponding mutations produce robust synaptic and behavioral changes. However, different neuroligin-3 mutations cause largely distinct phenotypes in mice, and
Publikováno v:
Alcoholism: Clinical and Experimental Research. 36:594-603
Background: Most adults in Western society consume alcohol regularly without negative consequences. For a small subpopulation, however, drinking can quickly progress to excessive and chronic intake. Given the dangers associated with alcohol abuse, it
Autor:
Patrick E. Rothwell, Byung Kook Lim, Marc V. Fuccillo, Scott J. Hayton, Gordon Sun, Robert C. Malenka
Publikováno v:
Neuron. 88(2)
SummaryThe serial ordering of individual movements into sequential patterns is thought to require synaptic plasticity within corticostriatal circuits that route information through the basal ganglia. We used genetically and anatomically targeted mani
Publikováno v:
Alcoholism, clinical and experimental research. 36(4)
Most adults in Western society consume alcohol regularly without negative consequences. For a small subpopulation, however, drinking can quickly progress to excessive and chronic intake. Given the dangers associated with alcohol abuse, it is critical
Impulsive action, the failure to withhold an inappropriate response, is treated clinically with dopamine agonists such as amphetamine. Despite the therapeutic efficacy, these drugs have inconsistent effects on impulsive action in rodents, causing imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b315046ebaa991627102068c7f1ae7f
https://europepmc.org/articles/PMC3260977/
https://europepmc.org/articles/PMC3260977/
Impulse control suppresses actions that are inappropriate in one context, but may be beneficial in others. The medial prefrontal cortex (mPFC) mediates this process by providing a top-down signal to inhibit competing responses, although the mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1590620672e0b3c0e9754457d48f50bf
https://europepmc.org/articles/PMC4844537/
https://europepmc.org/articles/PMC4844537/
Autor:
Carmen Chow, Megan K. Mahoney, Scott J. Hayton, Mary C. Olmstead, Katia Befort, Brigitte L. Kieffer
Publikováno v:
Psychopharmacology. 214(4)
Response inhibition, a primary symptom of many psychiatric disorders, is mediated through a complex neuropharmacological network that involves dopamine, serotonin, glutamate, noradrenaline, and cannabinoid mechanisms. Recently, we identified an opioi