Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Scott J. Goebel"'
Autor:
Mayanka Awasthi, Anthony Macaluso, Dawn Myscofski, Jon Prigge, Fusataka Koide, Ryan S. Noyce, Siobhan Fogarty, Helen Stillwell, Scott J. Goebel, Bruce Daugherty, Farooq Nasar, Sina Bavari, Seth Lederman
Publikováno v:
Vaccines, Vol 11, Iss 11, p 1682 (2023)
TNX-1800 is a synthetically derived live recombinant chimeric horsepox virus (rcHPXV) vaccine candidate expressing Wuhan SARS-CoV-2 spike (S) protein. The primary objective of this study was to evaluate the immunogenicity and efficacy of TNX-1800 in
Externí odkaz:
https://doaj.org/article/9b0fed184c9c458c8d58bfc900e14b55
Autor:
Mayanka Awasthi, Anthony Macaluso, Scott J. Goebel, Erin Luea, Ryan S. Noyce, Farooq Nasar, Bruce Daugherty, Sina Bavari, Seth Lederman
Publikováno v:
Viruses, Vol 15, Iss 10, p 2131 (2023)
TNX-1800 is a preclinical stage synthetic-derived live attenuated chimeric horsepox virus vaccine engineered to express the SARS-CoV-2 spike (S) gene. The objectives of this study were to assess the safety, tolerability, and immunogenicity of TNX-180
Externí odkaz:
https://doaj.org/article/2706dafabb4a422184b66f17fcd06e82
Autor:
Krishna P. Kota, Natasza E. Ziółkowska, Jiayi Wei, Junzhong Peng, David Ordonez, Christy Raney, Jon Prigge, Jay W. Hooper, Mayanka Awasthi, Scott J. Goebel, Brian A. Zabel, Farooq Nasar, Seth Lederman, Sina Bavari
Publikováno v:
Antiviral research.
Antibody-based therapy is emerging as a critical therapeutic countermeasure to treat acute viral infections by offering rapid protection against clinical disease. The advancements in structural biology made it feasible to rationalize monoclonal antib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2737ae186f2cf83ce87c6cded720fa52
https://pubmed.ncbi.nlm.nih.gov/36592670
https://pubmed.ncbi.nlm.nih.gov/36592670
Publikováno v:
Journal of Virology
The coronavirus nucleocapsid (N) protein plays an essential role in virion assembly via interactions with the large, positive-strand RNA viral genome and the carboxy-terminal endodomain of the membrane protein (M). To learn about the functions of N p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::621b111f8d464653df019d2fc6cdc2e9
Autor:
Cyrus V. Hedvat, Timothy E. Kiehn, Hugo Castro-Malaspina, Melissa Behr, Bradd C. Barr, William A. Samsonoff, Kelley R. Hurst, Scott J. Goebel, Cassandra D. Kelly, Paul S. Masters, Stephen W. Davis, Jill Taylor, Kim A. Rush-Wilson
Publikováno v:
Journal of Virology
An unknown virus was isolated from a lung biopsy sample and multiple other samples from a patient who developed a lethal case of pneumonia following a peripheral blood stem cell transplant. A random PCR-based molecular screening method was used to id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a583914254ac2519f54aacc13b940c2
https://doi.org/10.1128/jvi.01406-07
https://doi.org/10.1128/jvi.01406-07
Publikováno v:
Journal of Virology
The 3′ cis -acting element for mouse hepatitis virus (MHV) RNA synthesis resides entirely within the 301-nucleotide 3′ untranslated region (3′ UTR) of the viral genome and consists of three regions. Encompassing the upstream end of the 3′ UTR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9883292cc8c641963eaefecaf0606f14
https://doi.org/10.1128/jvi.00803-06
https://doi.org/10.1128/jvi.00803-06
Publikováno v:
Journal of Virology
RNA virus genomes contain cis -acting sequence and structural elements that participate in viral replication. We previously identified a bulged stem-loop secondary structure at the upstream end of the 3′ untranslated region (3′ UTR) of the genome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bc6aeca084db4a31323467321fe2e9a
https://doi.org/10.1128/jvi.78.2.669-682.2004
https://doi.org/10.1128/jvi.78.2.669-682.2004
Publikováno v:
Journal of Virology
The type I interferon (IFN) response plays an essential role in the control of in vivo infection by the coronavirus mouse hepatitis virus (MHV). However, in vitro , most strains of MHV are largely resistant to the action of this cytokine, suggesting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60f7343fb898863d15cf9536a8d6b670
https://pubmed.ncbi.nlm.nih.gov/20519394
https://pubmed.ncbi.nlm.nih.gov/20519394
Autor:
Joseph P. Winslow, Marion E. Perkus, Stephen W. Davis, Gerard P. Johnson, Enzo Paoletti, Scott J. Goebel
Publikováno v:
Virology. 181:378-381
Recently, we have reported the complete nucleotide sequence of vaccinia virus (Goebel, S. J., Johnson, G. P., Perkus, M. E., Davis, S. W., Winslow, l. P., and Paoletti, E. 1990, Virology 179, 247–266). Approximately 2.2 kbp leftward of the large su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2923154dd43ff36dd5c5a48598c3997
https://doi.org/10.1016/0042-6822(91)90508-9
https://doi.org/10.1016/0042-6822(91)90508-9
Autor:
Stephen W. Davis, Marion E. Perkus, Gerard P. Johnson, Elizabeth K. Norton, Enzo Paoletti, Scott J. Goebel
Publikováno v:
Virology. 180:406-410
Each copy of the inverted terminal repeat of vaccinia virus consists of 8 kb of DNA containing 9 ORFS flanked near the terminus of the genome by 4 kb of repetitive DNA which in turn contains blocks of tandem repeats. Using plasmids containing repetit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98bcb0ad60a94f7e041ae7588bbb7e33
https://doi.org/10.1016/0042-6822(91)90047-f
https://doi.org/10.1016/0042-6822(91)90047-f