Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Scott J. Eron"'
Autor:
Jodi Shaulsky, Andrew C. Good, Roman V. Agafonov, Tobie D. Lee, Christopher G. Nasveschuk, Andrew J. K. Phillips, Joe Sahil Patel, Ryan E. Michael, Hongwei Huang, Scott J. Eron, Mark E. Fitzgerald, Stewart L. Fisher, Ashley A. Hart
Publikováno v:
'ACS Chemical Biology ', vol: 16, pages: 2228-2243 (2021)
The field of targeted protein degradation (TPD) has grown exponentially over the past decade with the goal of developing therapies that mark proteins for destruction leveraging the ubiquitin-proteasome system. One common approach to achieve TPD is to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1cbcbb46e22a554e95dd60b690230ec
https://doi.org/10.1021/acschembio.1c00376
https://doi.org/10.1021/acschembio.1c00376
Autor:
Ashley A. Hart, Stewart L. Fisher, Christina S. Henderson, Scott J. Eron, David A. Proia, Roy M. Pollock, Prasoon Chaturvedi, James A. Henderson, S Perino, B. T Kreger, Christopher G. Nasveschuk, Adam S. Crystal, Andrew C. Good, Roman V. Agafonov, Marta Isasa, B Class, Michelle Mahler, R. J Kirby
Publikováno v:
Hematological Oncology. 39
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ff2f3296781240789b3754e21f66e68
https://doi.org/10.1002/hon.145_2880
https://doi.org/10.1002/hon.145_2880
Autor:
Katrina L. Jackson, Roman V. Agafonov, Mark W. Carlson, Prasoon Chaturvedi, David Cocozziello, Kyle Cole, Richard Deibler, Scott J. Eron, Andrew Good, Ashley A. Hart, Minsheng He, Christina S. Henderson, Hongwei Huang, Marta Isasa, R. Jason Kirby, Linda Lee, Michelle Mahler, Moses Moustakim, Christopher G. Nasveschuk, Michael Palmer, Laura L. Poling, Roy M. Pollock, Matthew Schnaderbeck, Stan Spence, Gesine K. Veits, Jeremy L. Yap, Ning Yin, Rhamy Zeid, Adam S. Crystal, Andrew J. Phillips, Stewart L. Fisher
Publikováno v:
Cancer Research. 82:ND09-ND09
Introduction: The chromatin factor BRD9 is a genetic dependency in some cancers, often referred to as SMARCB1-perturbed cancers. Two types of genetic alterations result in SMARCB1 perturbation: SS18-SSX gene fusion and SMARCB1 loss-of-function mutati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96b44ef5d9fa5dc56a4a294008bf6985
https://doi.org/10.1158/1538-7445.am2022-nd09
https://doi.org/10.1158/1538-7445.am2022-nd09
Autor:
James A. Henderson, Scott J. Eron, Andrew Good, R Jason Kirby, Samantha Perino, Roman V. Agafonov, Prasoon Chaturvedi, Bradley Class, David Cocozziello, Ashley A. Hart, Christina S. Henderson, Marta Isasa, Brendon Ladd, Matt Schnaderbeck, Michelle Mahler, Adam S. Crystal, Roy M. Pollock, Christopher G. Nasveschuk, Andrew J. Phillips, Stewart L. Fisher, David A. Proia
Publikováno v:
Cancer Research. 82:ND13-ND13
Introduction: Ikaros family zinc finger protein 1 and 3 (IKZF1/3) are essential transcription factors (TF) for terminal differentiation of B and T cells. Depletion of IKZF1/3 inhibits the growth of multiple myeloma (MM) cells, confirming their depend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42186bfdcb13c3303d47d3055f7346ca
https://doi.org/10.1158/1538-7445.am2022-nd13
https://doi.org/10.1158/1538-7445.am2022-nd13
Autor:
Joe Sahil Patel, Eunice S. Park, Chi-Li Chen, Andrew J. K. Phillips, Linda Lee, Thomas G. Scott, Christina S. Henderson, Ashley A. Hart, David A. Proia, James A. Henderson, W. Austin Elam, Catherine S. Oakes, Trang N. Tieu, Joelle Baddour, Mark C. Norley, Mathew E. Sowa, Jessica Freda, Marius S. Pop, Brendon Ladd, Minsheng He, Christopher G. Nasveschuk, Harit U. Vora, Gunther Kern, Gesine Kerstin Veits, Abigail Vogelaar, Stewart L. Fisher, Richard W. Deibler, Rhamy Zeid, Mark W. Carlson, Roman V. Agafonov, Arushi Jain, Graham P. Marsh, Prasoon Chaturvedi, Hannah J. Maple, Scott J. Eron, Emily S. Kibbler
Publikováno v:
Current Research in Chemical Biology, Vol 1, Iss, Pp 100010-(2021)
In addition to the therapeutic applicability of targeted protein degradation (TPD), the modality also harbors unique properties that enable the development of innovative chemical biology tools to interrogate complex biology. TPD offers an all-chemica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3fae8825e77dd3f8f25ec2a5b2702cc
http://www.sciencedirect.com/science/article/pii/S2666246921000100
http://www.sciencedirect.com/science/article/pii/S2666246921000100
Autor:
Scott J. Eron, Roy M. Pollock, Adam S. Crystal, James A. Henderson, Prasoon Chaturvedi, Christina S. Henderson, Samantha Perino, Stewart L. Fisher, Matt Schnaderbeck, Marta Isasa, Ashley A. Hart, Christopher G. Nasveschuk, Andrew C. Good, Roman V. Agafonov, R. Jason Kirby, Bradley Class, David Cocozziello, Michelle Mahler, David A. Proia, Andrew J. K. Phillips, Brendon Ladd
Publikováno v:
Cancer Research. 81:LB007-LB007
Introduction Ikaros family zinc finger protein 1 and 3 (IKZF1/3) are essential transcription factors (TF) for terminal differentiation of B and T cells. Depletion of IKZF1/3 in MM cells inhibits growth, confirming their dependency on IKZF1/3. IMiDs (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1aa2374fa57ec020d2e2ec7fb38e670b
https://doi.org/10.1158/1538-7445.am2021-lb007
https://doi.org/10.1158/1538-7445.am2021-lb007
Autor:
Scott J. Eron, Michael J. Knapp, John A. Hangasky, Cornelius Y. Taabazuing, Cristina B. Martin
Publikováno v:
Journal of Inorganic Biochemistry. 166:26-33
The factor inhibiting hypoxia inducible factor-1α (FIH) is a nonheme Fe(II)/αKG oxygenase using a 2-His-1-Asp facial triad. FIH activates O2 via oxidative decarboxylation of α-ketoglutarate (αKG) to generate an enzyme-based oxidant which hydroxyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7745f71b22ccd8f503e25b6d6a8b4c62
https://doi.org/10.1016/j.jinorgbio.2016.10.007
https://doi.org/10.1016/j.jinorgbio.2016.10.007
Autor:
Bach Pham, Min Chen, Monifa A. Fahie, Xin Li, Scott J. Eron, Maureen E. Hill, Jeanne A. Hardy
Publikováno v:
Biophys J
Caspases are an important protease family that coordinate inflammation and programmed cell death. Two closely related caspases, caspase-3 and caspase-7, exhibit largely overlapping substrate specificities. Assessing their proteolytic activities indiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1f7e603c292061ce483ab38a54cd98d
https://pubmed.ncbi.nlm.nih.gov/31427065
https://pubmed.ncbi.nlm.nih.gov/31427065
Publikováno v:
ACS chemical biology. 13(5)
Zinc is emerging as a widely used and important biological regulatory signal. Cellular zinc levels are tightly regulated by a complex array of zinc importer and exporters to control processes such as apoptotic cell death. While caspase inhibition by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c27a14d2e6750600b93cb34ef90af311
https://pubmed.ncbi.nlm.nih.gov/29364645
https://pubmed.ncbi.nlm.nih.gov/29364645
Therapeutic biologics have various advantages over synthetic drugs in terms of selectivity, their catalytic nature, and, thus, therapeutic efficacy. These properties offer the potential for more effective treatments that may also overcome the undesir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::089893b284221366e78b63277cf7ad57
https://europepmc.org/articles/PMC5714657/
https://europepmc.org/articles/PMC5714657/
