Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Scott J. Brantley"'
Autor:
Matthew Hitron, Michael D. Karol, Marjie L. Hard, Xiaoshu Dai, Colleen F. Mclaughlin, Scott J. Brantley, Matthew T. Goulet
Publikováno v:
Clinical Pharmacology in Drug Development
Napabucasin is an orally administered reactive oxygen species generator that is bioactivated by the intracellular antioxidant nicotinamide adenine dinucleotide phosphate:quinone oxidoreductase 1. Napabucasin induces cell death in cancer cells, includ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd249a6a220f2dc5c28a0e4212bd82e9
http://europepmc.org/articles/PMC8453567
http://europepmc.org/articles/PMC8453567
Publikováno v:
Clinical Pharmacology in Drug Development. 8:426-435
Azeliragon is an inhibitor of the receptor for advanced glycation end products being developed for the treatment of Alzheimer's disease. The objective of the current analysis was to evaluate the relationship between plasma azeliragon concentrations a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5344041863526549bc7b6456bf5ac507
https://doi.org/10.1002/cpdd.689
https://doi.org/10.1002/cpdd.689
Autor:
Ramon Gil, Bradford Navia, Stuart Isaacson, Yu-Yuan Chiu, Parul Bhargava, Scott J. Brantley, Felix Agbo
Publikováno v:
Neurology and Therapy
Introduction In a pivotal study, apomorphine sublingual film (APL; KYNMOBI®) was an effective and generally well-tolerated on-demand treatment of “OFF” episodes in patients with Parkinson’s disease (PD), approved across the dose range of 10–
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1ab1fb4df50abe15c13f4da6e863101
https://pubmed.ncbi.nlm.nih.gov/33991326
https://pubmed.ncbi.nlm.nih.gov/33991326
Autor:
Giuseppe Plazzi, Scott J. Brantley, Chad Ruoff, Katie Zomorodi, Mark Sale, Carol L. Rosen, Leslie H. Boyce, Cuiping Chen, Rupa Parvataneni
Publikováno v:
Clinical and Translational Science, Vol 13, Iss 5, Pp 932-940 (2020)
Clinical and Translational Science
Clinical and Translational Science
The pharmacokinetics (PKs) of sodium oxybate (SXB) was evaluated in a subset of participants from a study of SXB treatment in children (aged 7-11 years; n = 11) and adolescents (aged 12-17 years; n = 18) with narcolepsy with cataplexy. PK evaluation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b33878f03563ff40314de5d1e65204b
https://doi.org/10.1111/cts.12780
https://doi.org/10.1111/cts.12780
Autor:
Michael D. Karol, Marjie L. Hard, Scott J. Brantley, Xiaoshu Dai, Matthew T. Goulet, Colleen F. Mclaughlin, Matthew Hitron
Publikováno v:
Journal of Clinical Oncology. 38:142-142
142 Background: Napabucasin is an NQO1-bioactivatable investigational agent hypothesized to affect multiple oncogenic cellular pathways including pSTAT3 through the generation of reactive oxygen species. This phase 1 open-label study evaluated the DD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3fba3583533ad2021968f62cf1ae4f80
https://doi.org/10.1200/jco.2020.38.4_suppl.142
https://doi.org/10.1200/jco.2020.38.4_suppl.142
Discovery of small molecule inhibitors for the C. elegans caspase CED-3 by high-throughput screening
Autor:
Rihe Liu, Steven W. Cotten, David R. Lamson, Ginger R. Smith, Scott J. Brantley, Kevin P. Williams
Publikováno v:
Biochemical and biophysical research communications. 491(3)
C. elegans has been widely used as a model organism for programmed cell death and apoptosis. Although the CED-3 caspase is the primary effector of cell death in C. elegans, no selective inhibitors have been identified. Utilizing high-throughput scree
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94545de35cfd0635a3690b40722fe7db
https://pubmed.ncbi.nlm.nih.gov/28733033
https://pubmed.ncbi.nlm.nih.gov/28733033
Publikováno v:
Alzheimer's & Dementia. 13
Azeliragon is an inhibitor of the receptor for advanced glycation end products being developed for the treatment of Alzheimer's disease. The objective of the current analysis was to evaluate the relationship between plasma azeliragon concentrations a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b4f4ea26b270b033fb0ce0772d1cfcd
https://doi.org/10.1016/j.jalz.2017.06.133
https://doi.org/10.1016/j.jalz.2017.06.133
Publikováno v:
Drug Metabolism and Disposition. 42:301-317
Supported by a usage history that predates written records and the perception that "natural" ensures safety, herbal products have increasingly been incorporated into Western health care. Consumers often self-administer these products concomitantly wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7d33fb65c7288bc26201c594ea8c3bd
https://doi.org/10.1124/dmd.113.055236
https://doi.org/10.1124/dmd.113.055236
Autor:
Mary F. Paine, David J. Kroll, Tyler N. Graf, Mansukh C. Wani, Scott J. Brantley, Nicholas H. Oberlies, Rajesh Agarwal, Arlene A. Sy-Cordero, Stephen J. Polyak, Scott P. Runyon
Publikováno v:
Bioorganic & Medicinal Chemistry. 21:742-747
Flavonolignans from milk thistle (Silybum marianum) have been investigated for their cellular modulatory properties, including cancer chemoprevention and hepatoprotection, as an extract (silymarin), as partially purified mixtures (silibinin and isosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8235b16eafd95f27169f854f7052d846
https://doi.org/10.1016/j.bmc.2012.11.035
https://doi.org/10.1016/j.bmc.2012.11.035
Publikováno v:
Yamada' s Textbook of Gastroenterology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4edb822f488d196fc948a90e63f91a35
https://doi.org/10.1002/9781118512074.ch33
https://doi.org/10.1002/9781118512074.ch33
