Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Scott J. Baker"'
Autor:
Jaymin Upadhyay, Scott J Baker, Prasant Chandran, Loan Miller, Younglim Lee, Gerard J Marek, Unal Sakoglu, Chih-Liang Chin, Feng Luo, Gerard B Fox, Mark Day
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27839 (2011)
During wakefulness and in absence of performing tasks or sensory processing, the default-mode network (DMN), an intrinsic central nervous system (CNS) network, is in an active state. Non-human primate and human CNS imaging studies have identified the
Externí odkaz:
https://doaj.org/article/bd8d319d60d941108cea16c1a0f4051a
Autor:
Martin J. Voorbach, Terese R. Seifert, Scott J. Baker, Jason Stavropoulos, Xin Huang, Loren M. Lasko, Julie Carriker, Jaymin Upadhyay, La Geisha R. Lewis
Publikováno v:
Pain. 154:2782-2793
Subsequent to peripheral nerve compression and irritation, pathophysiological processes take place within nervous and immune systems. Here, we utilized a multimodal approach to comprehend peripheral and central soft tissue changes as well as alterati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc54e798eb2a542a22a5e2c167feecec
https://doi.org/10.1016/j.pain.2013.08.016
https://doi.org/10.1016/j.pain.2013.08.016
Autor:
Bradley A. Hooker, J. Hoppin, Prasant Chandran, G. Tobon, G.B. Fox, S.K. Joshi, Jaymin Upadhyay, Scott J. Baker, M. Day, K. Schmidt, J. Hesterman, Rajasimhan Rajagovindan, A.W. Bannon, John D. Beaver, C.Z. Zhu
Publikováno v:
European Journal of Pain. 18:223-237
Background The function of brain networks can be changed in a maladaptive manner in response to chronic neuropathic pain. Analgesics can reduce pain by acting on such networks via direct or indirect (peripheral or spinal) mechanisms. This investigati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89764a084372df231120dab910ca78dd
https://doi.org/10.1002/j.1532-2149.2013.00364.x
https://doi.org/10.1002/j.1532-2149.2013.00364.x
Autor:
Andrew O. Stewart, Janel M. Boyce-Rustay, Ivan Milicic, Chang Z. Zhu, Jill M. Wetter, Timothy A. Vortherms, Michael F. Jarvis, Marian T. Namovic, Diana L. Donnelly-Roberts, Chengmin Zhong, Victoria E. Scott, Karen Kage, Rodger F. Henry, Erica Gomez, Scott J. Baker, Carol S. Surowy, Daria Darczak, Pamela H. Franklin, Gricelda H. Simler, Wende Niforatos, Richard S. Janis, Andrew M. Swensen, Kennan C. Marsh, Xenia Beebe
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:4128-4139
A novel 4-aminocyclopentapyrrolidine series of N-type Ca(2+) channel blockers have been discovered. Enantioselective synthesis of the 4-aminocyclopentapyrrolidines was enabled using N-tert-butyl sulfinamide chemistry. SAR studies demonstrate selectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::903d471b779294dbab78f23177d949d0
https://doi.org/10.1016/j.bmc.2012.04.057
https://doi.org/10.1016/j.bmc.2012.04.057
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 341:263-273
In vivo translational imaging techniques, such as positron emission tomography and single-photon emission-computed tomography, are the only ways to adequately determine that a drug engages its target. Unfortunately, there are far more experimental me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4db7aa1409f41e9dd88787bdb80fbf40
https://doi.org/10.1124/jpet.111.188797
https://doi.org/10.1124/jpet.111.188797
Autor:
Chih-Hung Lee, Ann Tovcimak, Michael W. Decker, Gerard B. Fox, Gricelda H. Simler, Prisca Honore, Jordan W. Brown, Chang Z. Zhu, Madhavi Pai, Nathan R. Rustay, Chih-Liang Chin, Chengmin Zhong, Joe Mikusa, Murali Gopalakrishnan, Victoria A. Komater, Donna M. Gauvin, Anita K. Salyers, Scott J. Baker, La Geisha Lewis, Peer B. Jacobson, Erica Gomez, Prasant Chandran
Publikováno v:
Biochemical Pharmacology. 82:967-976
Positive modulation of the neuronal nicotinic acetylcholine receptor (nAChR) α4β2 subtype by selective positive allosteric modulator NS-9283 has shown to potentiate the nAChR agonist ABT-594-induced anti-allodynic activity in preclinical neuropathi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1340266ffc68c882923bbd524daa5706
https://doi.org/10.1016/j.bcp.2011.05.007
https://doi.org/10.1016/j.bcp.2011.05.007
Autor:
Arthur A. Hancock, Jill M. Wetter, Kennan C. Marsh, Prisca Honore, Gin C. Hsieh, Anita K. Salyers, Prasant Chandran, Timothy A. Esbenshade, Marlon D. Cowart, Joe Mikusa, Jorge D. Brioni, Erica J. Wensink, Madhavi Pai, Thomas R. Miller, Scott J. Baker, Chang Z. Zhu, David G. Witte
Publikováno v:
Pharmacology Biochemistry and Behavior. 95:41-50
The histamine H(4) receptor (H(4)R) is expressed primarily on cells involved in inflammation and immune responses. To determine the potential role of H(4)R in pain transmission, the effects of JNJ7777120, a potent and selective H(4) antagonist, were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3217e8b864839ddd3ab2c66a0d548d8d
https://doi.org/10.1016/j.pbb.2009.12.004
https://doi.org/10.1016/j.pbb.2009.12.004
Autor:
Chang Z. Zhu, Peter R. Hollingsworth, Donna M. Gauvin, Sonya G. Lehto, Renjie Chang, Prisca Honore, Jorge D. Brioni, Scott J. Baker, Gricelda Hernandez, GuoZhu Zheng, Robert B. Moreland, Odile EI-Kouhen, Andrew O. Stewart
Publikováno v:
European Journal of Pharmacology. 580:314-321
Activation of metabotropic glutamate (mGlu) receptors has previously been shown to play a role in inflammatory or neuropathic pain states. However, the role of mGlu type 1 receptors in post-operative pain remains to be investigated. In the present st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dc7c4bfb04efdede560e59d69f8a707
https://doi.org/10.1016/j.ejphar.2007.09.047
https://doi.org/10.1016/j.ejphar.2007.09.047
Autor:
Scott J. Baker, Loan N. Miller, Meena V. Patel, Marie E. Uchic, Kennan C. Marsh, Prisca Honore, Renjie Chang, Odile F. El Kouhen, Guo Zhu Zheng, Pramila Bhatia, Jorge D. Brioni, Robert B. Moreland, Sonya G. Lehto, Jill M. Wetter, Andrew O. Stewart, Teodozyj Kolasa
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:4936-4940
We have discovered a novel, potent, and selective triazafluorenone series of metabotropic glutamate receptor 1 (mGluR1) antagonists with efficacy in various rat pain models. Pharmacokinetic and pharmacodynamic profiles of these triazafluorenone analo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed3fefa2375e1ca3c4771a874d443080
https://doi.org/10.1016/j.bmcl.2006.06.053
https://doi.org/10.1016/j.bmcl.2006.06.053
Autor:
Joseph P. Mikusa, Prisca Honore, Gricelda Hernandez, Karen Kage, Wende Niforatos, Char-Chang Shieh, Torben R. Neelands, Michael F. Jarvis, S.K. Joshi, Xu-Feng Zhang, Ping Han, Connie R. Faltynek, James P. Sullivan, Scott J. Baker, Douglas S. Krafte
Publikováno v:
Pain. 123:75-82
Antisense (AS) oligodeoxynucleotides (ODNs) targeting the Nav 1.8 sodium channel have been reported to decrease inflammatory hyperalgesia and L5/L6 spinal nerve ligation-induced mechanical allodynia in rats. The present studies were conducted to furt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cebe463587933aa120d7f01b256841e2
https://doi.org/10.1016/j.pain.2006.02.011
https://doi.org/10.1016/j.pain.2006.02.011