Host genetics and environmental factors regulate ecological succession of the mouse colon tissue-associated microbiota.

Autor: Philip Smith, Jay Siddharth, Ruth Pearson, Nicholas Holway, Mark Shaxted, Matt Butler, Natalie Clark, Joanna Jamontt, Robert P Watson, Devika Sanmugalingam, Scott J Parkinson

Publikováno v: PLoS ONE, Vol 7, Iss 1, p e30273 (2012)

BackgroundThe integration of host genetics, environmental triggers and the microbiota is a recognised factor in the pathogenesis of barrier function diseases such as IBD. In order to determine how these factors interact to regulate the host immune re

Externí odkaz: https://doaj.org/article/868d8b721b554e8fb62f7e52217778fe

Transcriptomics-driven lipidomics (TDL) identifies the microbiome-regulated targets of ileal lipid metabolism

Autor: Bertrand Betrisey, Mojgan Masoodi, Hugues Henry, Stephen J. Bruce, Sylviane Metairon, Frederic Raymond, Mathieu Membrez, Scott J. Parkinson, Anirikh Chakrabarti, Jay Siddharth, Delphine Morin-Rivron, Carole Loyer, Chieh Jason Chou

Publikováno v: npj Systems Biology and Applications, Vol 3, Iss 1, Pp 1-15 (2017)
NPJ Systems Biology and Applications
NPJ systems biology and applications, vol. 3, pp. 33

The gut microbiome and lipid metabolism are both recognized as essential components in the maintenance of metabolic health. The mechanisms involved are multifactorial and (especially for microbiome) poorly defined. A strategic approach to investigate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2315167e482e0eebcb95c3481315403c
http://link.springer.com/article/10.1038/s41540-017-0033-0

Complete Genome Sequence of Escherichia coli Strain M8, Isolated from ob/ob Mice

Autor: Bertrand Betrisey, Mathieu Membrez, Scott J. Parkinson, Jay Siddharth, Anirikh Chakrabarti, Chieh Jason Chou

Publikováno v: Genome Announcements

Escherichia coli is one of the common inhabitants of the mammalian gastrointestinal track. We isolated a strain from an ob/ob mouse and performed whole-genome sequencing, which yielded a chromosome of ~5.1 Mb and three plasmids of ~160 kb, ~6 kb, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23268ba20edc710428750bc50633d89b
http://europepmc.org/articles/PMC5454205

Cohort Specific Effects of Cereal-bar Supplementation in Overweight Patients With or Without Type 2 Diabetes Mellitus

Autor: Anne Chalut-Carpentier, Jay Siddharth, Zoltan Pataky, Christian L. Lauber, Scott J. Parkinson, Chieh Jason Chou, Anirikh Chakrabarti, Alain Golay

The importance of gut microbes to metabolic health is becoming more evident and nutrition-based therapies to alter the composition of bacterial communities to manage metabolic disease are an attractive avenue to ameliorate some effects of Western die

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e33f461e31059e9204411cb71d8f8bf

Impairment of adenosine A3 receptor activity disrupts neutrophil migratory capacity and impacts innate immune function in vivo

Autor: Scott J. Parkinson, Matt Butler, Devika Sanmugalingam, Ruth Pearson, Philip Smith, Robert P. Watson, Tammy Wilson, Victoria J. Burton

Publikováno v: European Journal of Immunology. 42:3358-3368

Adenosine possesses potent anti-inflammatory properties which are partly mediated by G(i) -coupled adenosine A3 receptors (A3Rs). A3R agonists have shown clinical benefit in a number of inflammatory conditions although some studies in A3R-deficient m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::222cee20d5f269e3b168bf1bb929c4f2
https://doi.org/10.1002/eji.201242655