Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Scott J, Weir"'
Autor:
David Standing, Prasad Dandawate, Sumedha Gunewardena, Obdulia Covarrubias-Zambrano, Katherine F. Roby, Dineo Khabele, Andrea Jewell, Ossama Tawfik, Stefan H. Bossmann, Andrew K. Godwin, Scott J. Weir, Roy A. Jensen, Shrikant Anant
Publikováno v:
Cell Death and Disease, Vol 15, Iss 5, Pp 1-16 (2024)
Abstract Advanced epithelial ovarian cancer (EOC) survival rates are dishearteningly low, with ~25% surviving beyond 5 years. Evidence suggests that cancer stem cells contribute to acquired chemoresistance and tumor recurrence. Here, we show that IRA
Externí odkaz:
https://doaj.org/article/a34cd1f4ae354f69b2bfaed9395015fa
Fosciclopirox suppresses growth of high-grade urothelial cancer by targeting the γ-secretase complex
Autor:
Scott J. Weir, Prasad Dandawate, David Standing, Sangita Bhattacharyya, Prabhu Ramamoorthy, Parthasarathy Rangarajan, Robyn Wood, Amanda E. Brinker, Benjamin L. Woolbright, Mehmet Tanol, Tammy Ham, William McCulloch, Michael Dalton, Gregory A. Reed, Michael J. Baltezor, Roy A. Jensen, John A. Taylor, Shrikant Anant
Publikováno v:
Cell Death and Disease, Vol 12, Iss 6, Pp 1-20 (2021)
Abstract Ciclopirox (CPX) is an FDA-approved topical antifungal agent that has demonstrated preclinical anticancer activity in a number of solid and hematologic malignancies. Its clinical utility as an oral anticancer agent, however, is limited by po
Externí odkaz:
https://doaj.org/article/d4bbf6c8245447f1b012189797bdb6c4
Autor:
Dharmalingam Subramaniam, Pablo Angulo, Sivapriya Ponnurangam, Prasad Dandawate, Prabhu Ramamoorthy, Pugazhendhi Srinivasan, Tomoo Iwakuma, Scott J. Weir, Katherine Chastain, Shrikant Anant
Publikováno v:
Cell Death and Disease, Vol 11, Iss 2, Pp 1-15 (2020)
Abstract Osteosarcoma (OS) is the most common primary bone tumor that primarily affects children and adolescents. Studies suggested that dysregulation JAK/STAT signaling promotes the development of OS. Cells treated with pimozide, a STAT5 inhibitor s
Externí odkaz:
https://doaj.org/article/5d310a6efbe6464b9de53da6369710ad
Autor:
Najla Kfoury, Tao Sun, Kwanha Yu, Nathan Rockwell, Kelsey L. Tinkum, Zongtai Qi, Nicole M. Warrington, Peter McDonald, Anuradha Roy, Scott J. Weir, Carrie A. Mohila, Benjamin Deneen, Joshua B. Rubin
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-13 (2018)
Abstract Mechanisms underlying sex differences in cancer incidence are not defined but likely involve dimorphism (s) in tumor suppressor function at the cellular and organismal levels. As an example, sexual dimorphism in retinoblastoma protein (Rb) a
Externí odkaz:
https://doaj.org/article/be8f708cece04a41bfd595a9a82149a8
Autor:
David Standing, Levi Arnold, Prasad Dandawate, Brendan Ottemann, Vusala Snyder, Sivapriya Ponnurangam, Afreen Sayed, Dharmalingam Subramaniam, Pugazhendhi Srinivasan, Sonali Choudhury, Jacob New, Deep Kwatra, Prabhu Ramamoorthy, Badal C. Roy, Melissa Shadoin, Raed Al‐Rajabi, Maura O'Neil, Sumedha Gunewardena, John Ashcraft, Shahid Umar, Scott J. Weir, Ossama Tawfik, Subhash B. Padhye, Bernhard Biersack, Shrikant Anant, Sufi Mary Thomas
Publikováno v:
Molecular Carcinogenesis. 62:145-159
Doublecortin like kinase 1 (DCLK1) plays a crucial role in several cancers including colon and pancreatic adenocarcinomas. However, its role in squamous cell carcinoma (SCC) remains unknown. To this end, we examined DCLK1 expression in head and neck
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fd9a55de8758a49d33e008a5ba3586e
https://doi.org/10.1002/mc.23472
https://doi.org/10.1002/mc.23472
PDF file - 1279K, Table S1: List of FDA-approved drug library; Table S2: Screen parameters; Table S3: Curve classification criteria; Table S4: Screening of FDA-approved drugs on Hs 919.T. cell line hits summary; Table S5: Drug structures of candidate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82a335ab44ca519c5890a4575727d96c
https://doi.org/10.1158/1535-7163.22499692.v1
https://doi.org/10.1158/1535-7163.22499692.v1
Autor:
Andrew K. Godwin, Scott J. Weir, Margaret von Mehren, Jeff J. Hirst, Yan Ma, Ziyan Y. Pessetto
Gastrointestinal stromal tumor (GIST) is a rare and therefore often neglected disease. Introduction of the kinase inhibitor imatinib mesylate radically improved the clinical response of patients with GIST; however, its effects are often short-lived,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91f5c74e0ab6ca8149686ccf1aa2f9b5
https://doi.org/10.1158/1535-7163.c.6536842.v1
https://doi.org/10.1158/1535-7163.c.6536842.v1
Autor:
Shrikant Anant, Somesh Sharma, Arun Balakrishnan, Scott J. Weir, Muralidhara Padigaru, Aravind Sugumar, Debarshi Chakrabarti, Sivapriya Ponnurangam, Giridharan Periyasamy, Dharmalingam Subramaniam
PDF file, 709KB, The list of primers used for Real Time RT-PCR are shown in this table.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4a4de6be9c0a79913f36e27e7e5b959
https://doi.org/10.1158/1535-7163.22499176.v1
https://doi.org/10.1158/1535-7163.22499176.v1
Autor:
Shrikant Anant, Somesh Sharma, Arun Balakrishnan, Scott J. Weir, Muralidhara Padigaru, Aravind Sugumar, Debarshi Chakrabarti, Sivapriya Ponnurangam, Giridharan Periyasamy, Dharmalingam Subramaniam
Despite advances in molecular pathogenesis, pancreatic cancer remains a major unsolved health problem. It is a rapidly invasive, metastatic tumor that is resistant to standard therapies. The phosphatidylinositol-3-kinase/Akt and mTOR signaling pathwa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f67b4e9ae0ff5e5add64002a28940185
https://doi.org/10.1158/1535-7163.c.6536086
https://doi.org/10.1158/1535-7163.c.6536086
Despite significant treatment advances over the past decade, metastatic gastrointestinal stromal tumor (GIST) remains largely incurable. Rare diseases, such as GIST, individually affect small groups of patients but collectively are estimated to affec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c490df5a6b47a9d599a1b71c15419f09
https://doi.org/10.1158/1535-7163.c.6536224
https://doi.org/10.1158/1535-7163.c.6536224