Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Scott I. Klein"'
Autor:
Scott I. Klein, M. Jonathan Rudolph, Carl R. Illig, Ehab Khalil, Farah Ali, John C. Spurlino, Renee L. DesJarlais, Carl Crysler, Philip E. Morris, J. M. Kilpatrick, Richard Soll, Y. Sudhakara Babu, Nalin L. Subasinghe, Roger F. Bone, Maxwell D. Cummings
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:3043-3047
Activation of the classical pathway of complement has been implicated in disease states such as hereditary angioedema, ischemia-reperfusion injury and acute transplant rejection. The trypsin-like serine protease C1s represents a pivotal upstream poin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::addf75fd0711fd907fcd1bea0ceebeab
https://doi.org/10.1016/j.bmcl.2004.04.034
https://doi.org/10.1016/j.bmcl.2004.04.034
Publikováno v:
European Journal of Medicinal Chemistry. 32:833-839
Summary A series of nonpeptide fibrinogen receptor antagonists based upon the tetrapeptide Arg-Gly-Asp-Arg were prepared. These relatively simple derivatives incorporate a high degree of conformational flexibility that was anticipated to allow them t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27787ba161609a2177617136dde775a3
https://doi.org/10.1016/s0223-5234(99)80069-5
https://doi.org/10.1016/s0223-5234(99)80069-5
Autor:
Rose D'Alisa, Bruce F. Molino, Scott I. Klein, Jeffrey M Dener, Robert J. Leadley, Charles Kasiewski, Christopher T. Dunwiddie, Charles J. Gardner
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:2225-2230
A series of analogs were prepared based on the known thrombin inhibitor PPACK, in which the D-Phe-Pro dipeptide has been replaced by trans-4-O-benzyl hydroxyproline. One of these analogs is a more potent inhibitor of thrombin, and is more selective,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c89f7d9bba49b5b6a674a2c67451aa9b
https://doi.org/10.1016/0960-894x(96)00404-0
https://doi.org/10.1016/0960-894x(96)00404-0
Autor:
Robert J. Leadley, Bruce F. Molino, Scott I. Klein, Jeffrey S Dener, Christopher T. Dunwiddie, Ralph D. Sabatino, Mark Czekaj, Valeria Chu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:1403-1408
Structure-activity relationships developed from work with peptide based fibrinogen receptor antagonists have been successfully applied to the development of simple and highly potent nonpeptide agents of the same class.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da81eb78b2d474e0007dce3ec31aef6f
https://doi.org/10.1016/0960-894x(96)00236-3
https://doi.org/10.1016/0960-894x(96)00236-3
Autor:
Rose D'Alisa, Scott I. Klein, Jeffrey M Dener, Bruce F. Molino, Charles Kasiewski, Charles J. Gardner, Robert J. Leadley, Christopher T. Dunwiddie
Publikováno v:
ChemInform. 28
A series of analogs were prepared based on the known thrombin inhibitor PPACK, in which the D-Phe-Pro dipeptide has been replaced by trans-4-O-benzyl hydroxyproline. One of these analogs is a more potent inhibitor of thrombin, and is more selective,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51bc0adeca56d88ae083220017d858bc
https://doi.org/10.1002/chin.199703251
https://doi.org/10.1002/chin.199703251
Autor:
Mark Czekaj, Valeria Chu, Karen D. Brown, Scott I. Klein, Dennis J. Colussi, Robert J. Leadley, Christopher Heran, Ross Bentley, Charles Kasiewski, Mark H. Perrone, Suzanne Morgan, Jeffrey S. Bostwick
Publikováno v:
European journal of pharmacology. 389(2-3)
Coagulation factor Xa is the sole enzyme responsible for activating the zymogen prothrombin to thrombin, resulting in fibrin generation, platelet activation, and subsequent thrombus formation. Our objective was to evaluate the antithrombotic efficacy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a3a1cef29a56f91742220c77bfd8d7a
https://pubmed.ncbi.nlm.nih.gov/10688985
https://pubmed.ncbi.nlm.nih.gov/10688985
Autor:
Charles Kasiewski, Scott I. Klein, Mark Czekaj, Valeria Chu, Karen D. Brown, Jeffrey S. Bostwick, Vincent Windisch, Christopher T. Dunwiddie, Ross Bentley, Bruce F. Molino, Charles J. Gardner, Ralph D. Sabatino, Robert J. Leadley, Mark H. Perrone
Publikováno v:
Journal of medicinal chemistry. 41(14)
The integrin receptor recognition sequence Arg-Gly-Asp was successfully used as a template from which to develop a series of potent, selective, orally active, peptide-based fibrinogen receptor antagonists with a long duration of action. Simple modifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc0dbc9ed14b77ac018388888886dfc6
https://pubmed.ncbi.nlm.nih.gov/9651154
https://pubmed.ncbi.nlm.nih.gov/9651154
Autor:
Karen S. Brown, Mark H Perrone, Alfred P. Spada, Valeria Chu, Christopher L. Heran, Mark Czekaj, Scott A. Bolton, Guertin Kevin R, Scott I. Klein, Robert J. Leadley, Christopher T. Dunwiddie, Dennis Colussi, Charles J. Gardner, Daniel L. Cheney, Suzanne R. Morgan
Publikováno v:
Journal of medicinal chemistry. 41(4)
The discovery and some of the basic structure-activity relationships of a series of novel nonpeptide inhibitors of blood coagulation Factor Xa is described. These inhibitors are functionalized beta-alanines, exemplified by 2a. Docking experiments pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97d4721b080eb3d9aed62af4db53673b
https://pubmed.ncbi.nlm.nih.gov/9484495
https://pubmed.ncbi.nlm.nih.gov/9484495
Autor:
Robert J. Leadley, Christopher T. Dunwiddie, Scott I. Klein, Jeffrey S. Bostwick, Ralph D. Sabatino, Charles Kasiewski, Valeria Chu, Mark H. Perrone, Jacquelynn J. Cook
Publikováno v:
Thrombosis research. 82(6)
RG13965, a pseudotetrapeptide analogue of Arg-Gly-Asp (RGD), inhibited collagen-induced dog, monkey, human, hamster, mouse, and pig platelet aggregation in vitro with IC 50 values of 3.7, 4.6, 6.3, 126, 136 and 1600 μM, respectively. RG13965 (3, 10,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bf40899347c4bc5bb98d5f2925c87e5
https://pubmed.ncbi.nlm.nih.gov/8794522
https://pubmed.ncbi.nlm.nih.gov/8794522
Autor:
Scott I. Klein, Jacquelynn J. Cook, Zaverio M. Ruggeri, Bruce F. Molino, Mark Czekaj, Valeria Chu, Charles Kasiewski, Jeffrey S. Bostwick
Publikováno v:
Peptides 1992 ISBN: 9789401046466
Peptides 1992
Peptides 1992
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75897ed5e33a4636008842a82f191484
https://doi.org/10.1007/978-94-011-1470-7_288
https://doi.org/10.1007/978-94-011-1470-7_288
