Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Scott Hoerrner"'
Autor:
Baoqiang Wan, Scott Hoerrner, Jaume Balsells, Lu Chen, Bangping Xiang, Qinghao Chen, Lushi Tan, Carmela Molinaro, Eric M. Phillips, Zhongbo Fei, Jingjun Yin, Scott S. Ceglia, Ji Qi, Jiahui Chen, Michael Shevlin, Manuel de Lera Ruiz, Erika M. Milczek
Publikováno v:
The Journal of organic chemistry. 84(12)
A practical and efficient enantioselective synthesis of the calcitonin gene-related peptide receptor antagonist 1 has been developed. The key structural component of the active pharmaceutical ingredient is a syn-1,2-amino-fluoropiperidine 4. Two appr
Autor:
R. Scott Hoerrner, Juan D. Arredondo, C. Scott Shultz, Takahiro Itoh, Xianghui Wen, Debra J. Wallace, Jason L. Nyrop, Dalian Zhao, Paul G. Bulger, Daniel J. Muzzio, Lushi Tan, Ephraim M. Bassan, Qinghao Chen, Mark Weisel, Sarah J. Dolman, Chengfu Xie, Pintipa Grongsaard
Publikováno v:
Organic Process Research & Development. 16:1069-1081
The development of a convergent, chromatography-free synthesis of an allosteric Akt kinase inhibitor is described. The route comprised 17 total steps and was used to produce kilogram quantities of the target molecule. A key early transformation, for
Autor:
Richard Desmond, Paul N. Devine, Naoki Yoshikawa, Feng Xu, Michael J. Zacuto, Neil A. Strotman, Tetsuji Itoh, Scott Hoerrner, Michel Journet, Cameron J. Cowden, Guy R. Humphrey
Publikováno v:
The Journal of Organic Chemistry. 75:7829-7841
A highly efficient, asymmetric synthesis of telcagepant (1), a CGRP receptor antagonist for the treatment of migraine, is described. This synthesis features the first application of iminium organocatalysis on an industrial scale. The key to the succe
Autor:
Christian Nadeau, Jacob M. Janey, Greg Hughes, Rick Sidler, Michael Palucki, Paul D. O’Shea, Francis Gosselin, Danny Gauvreau, Robert A. Britton, Ian W. Davies, Carmela Molinaro, Sarah J. Dolman, R. Scott Hoerrner, Stephen Lau
Publikováno v:
The Journal of Organic Chemistry. 75:4154-4160
Practical, chromatography-free syntheses of 5-lipoxygenase inhibitor MK-0633 p-toluenesulfonate (1) are described. The first route used an asymmetric zincate addition to ethyl 2,2,2-trifluoropyruvate followed by 1,3,4-oxadiazole formation and reducti
Publikováno v:
Organic Process Research & Development. 10:149-152
An efficient one-pot procedure for the four-step preparation of 7-hydroxyquinoline (1) from 3-N-tosylaminophenol (4) in 60% isolated yield, that reduces the risk of exposure to acrolein (2), is described.
Autor:
Wenjie Li, Gary Javadi, Dongwei Cai, Robert D. Larsen, Mark S. Jensen, R. Scott Hoerrner, Dorian P. Nelson, Peter G. Dormer
Publikováno v:
The Journal of Organic Chemistry. 70:6034-6039
A practical synthesis of 2-[3-(4-fluoro-3-pyridin-3-yl-phenyl)-imidazo[1,2-a]pyrimidin-7-yl]-propan-2-ol (1), an oral GABA(A) alpha(2/3)-selective agonist, is described. The five-step process, which afforded 1 in 40% overall yield, included imidazopy
Publikováno v:
Organic Process Research & Development. 11:739-741
An efficient one-pot process for the preparation of pure (R)-N-[3-(4-iodophenyl)-2-oxo-5-oxazolidinyl]methylacetamide 1 from the mesylate 2b in 91% yield has been developed. The one-pot process makes use of commercially available sodium diformylamide
Publikováno v:
Tetrahedron Letters. 39:3455-3458
Asymmetric hydrogenation of a protected (Z)-dehydro-β-methyltryptophan derivative 2 with (R,R)-Me-DuPHOS-Rh catalysis was achieved in 97 % ee. Deprotection then afforded (2R,3S)-β-methyltryptophan 1.
Publikováno v:
Antiviral Drugs: From Basic Discovery through Clinical Trials
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d962a31663dcb22fa5c729bb50df6c9
https://doi.org/10.1002/9780470929353.ch12
https://doi.org/10.1002/9780470929353.ch12
Publikováno v:
ChemInform. 29