Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Scott Heyward"'
Autor:
Kaiyan Liu, Sydney Stern, Emily L. Heil, Linhao Li, Rula Khairi, Scott Heyward, Hongbing Wang
Publikováno v:
Hepatology Communications, Vol 7, Iss 3, Pp e0034-e0034 (2023)
Background:. Coronavirus disease 2019 (COVID-19) is a global pandemic that has caused more than 600 million cases and over six million deaths worldwide. Despite the availability of vaccination, COVID-19 cases continue to grow making pharmacological i
Externí odkaz:
https://doaj.org/article/2380619583fe46a091bae04a9790017d
Autor:
Hongbing Wang, Paul C. Brown, Edwin C.Y. Chow, Lorna Ewart, Stephen S. Ferguson, Suzanne Fitzpatrick, Benjamin S. Freedman, Grace L. Guo, William Hedrich, Scott Heyward, James Hickman, Nina Isoherranen, Albert P. Li, Qi Liu, Shannon M. Mumenthaler, James Polli, William R. Proctor, Alexandre Ribeiro, Jian‐Ying Wang, Ronald L. Wange, Shiew‐Mei Huang
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 5, Pp 1659-1680 (2021)
Abstract Nonclinical testing has served as a foundation for evaluating potential risks and effectiveness of investigational new drugs in humans. However, the current two‐dimensional (2D) in vitro cell culture systems cannot accurately depict and si
Externí odkaz:
https://doaj.org/article/523a044f71fe468699fe3793345748a3
Autor:
Sydney Stern, Dongdong Liang, Linhao Li, Ritika Kurian, Caitlin Lynch, Srilatha Sakamuru, Scott Heyward, Junran Zhang, Kafayat Ajoke Kareem, Young Wook Chun, Ruili Huang, Menghang Xia, Charles C. Hong, Fengtian Xue, Hongbing Wang
Publikováno v:
JCI Insight, Vol 7, Iss 12 (2022)
Cyclophosphamide (CPA) and doxorubicin (DOX) are key components of chemotherapy for triple-negative breast cancer (TNBC), although suboptimal outcomes are commonly associated with drug resistance and/or intolerable side effects. Through an approach c
Externí odkaz:
https://doaj.org/article/1a8ce16626d14dd984fe688ea0acc24d
Autor:
Theresa Aliwarga, Jean C. Dinh, Scott Heyward, Bhagwat Prasad, Sina A. Gharib, Rozenn N. Lemaitre, Nona Sotoodehnia, Rheem A. Totah
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 20, p 12433 (2022)
CYP2J2 is the main epoxygenase in the heart that is responsible for oxidizing arachidonic acid to cis-epoxyeicosatrienoic acids (EETs). Once formed, EETs can then be hydrolyzed by soluble epoxide hydrolase (sEH, encoded by EPHX2) or re-esterified bac
Externí odkaz:
https://doaj.org/article/a48cbf9525a046139bd97ff4f7e03b83
Autor:
Zhihui Li, Linhao Li, Scott Heyward, Shuaiqian Men, Meishu Xu, Tatsuya Sueyoshi, Hongbing Wang
Publikováno v:
Cells, Vol 10, Iss 12, p 3381 (2021)
Phenobarbital (PB), a widely used antiepileptic drug, is known to upregulate the expression of numerous drug-metabolizing enzymes and transporters in the liver primarily via activation of the constitutive androstane receptor (CAR, NR1I3). The solute
Externí odkaz:
https://doaj.org/article/f94cc84993584ee885761d4bfe1cf703
Autor:
Sydney Stern, Dongdong Liang, Linhao Li, Ritika Kurian, Caitlin Lynch, Scott Heyward, Ajoke Kareem, Young Chun, Charles Hong, Fengtian Xue, Hongbing Wang
Publikováno v:
Journal of Clinical and Translational Science, Vol 5, Pp 98-98 (2021)
ABSTRACT IMPACT: Triple negative breast cancer (TNBC) affects 10-20% of women with breast cancer and is biologically more aggressive than other subtypes. The novel compound we have developed, DL7076, would give clinicians a vital strategy to improve
Externí odkaz:
https://doaj.org/article/eff90bbab36e49628ea8e6aba041e053
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150587 (2016)
CYP2B6 plays an increasingly important role in xenobiotic metabolism and detoxification. The constitutive androstane receptor (CAR) and the pregnane X receptor (PXR) have been established as predominant regulators for the inductive expression of CYP2
Externí odkaz:
https://doaj.org/article/36f0330d916a4a13ac4fc11de3f18d05
Autor:
Sheena Sharma, Dilip K. Singh, Vijay S. Mettu, Guihua Yue, Deepak Ahire, Abdul Basit, Scott Heyward, Bhagwat Prasad
Publikováno v:
Molecular Pharmaceutics. 20:1737-1749
Autor:
Abdul Basit, John K. Amory, Vijaya Saradhi Mettu, Cindy Yanfei Li, Scott Heyward, Parth B. Jariwala, Matthew R. Redinbo, Bhagwat Prasad
Publikováno v:
Drug Metabolism and Disposition. 51:427-435
Autor:
Sheena Sharma, Deepak Ahire, Abdul Basit, Maria Lajoie, Christina Wang, Min S. Lee, Diana L. Blithe, John K. Amory, Dilip K. Singh, Scott Heyward, Bhagwat Prasad
Publikováno v:
Drug Metab Dispos
Dimethandrolone undecanoate (DMAU), an oral investigational male hormonal contraceptive, is a prodrug that is rapidly converted to its active metabolite, dimethandrolone (DMA). Poor and variable oral bioavailability of DMA after DMAU dosing is a crit