Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Scott Harried"'
Autor:
James R. Prudent, Fabio Malavasi, Mohammed S. Shekhani, John L Murphy, Chad A Hall, Antonella Chillemi, David J. Marshall, Christophe Pain, Jon S. Thorson, Conner A Lyons, Homer L Pearce, Scott Harried
Publikováno v:
Molecular Therapy
The human Na+/K+-ATPase (NKA) is a plasma membrane ion pump that uses ATP to help maintain the resting potential of all human cells. Inhibition of the NKA leads to cell swelling and death. The results of this investigation show that on cancer cells,
Autor:
Jeffrey Clarine, Qingyian Liu, Beth D. Youngblood, Chester Chenguang Yuan, Michelle Horner, James Brown, Jian J. Chen, Michael D. Bartberger, Vu Van Ma, Matthew R. Kaller, Carl D. Davis, Maosheng Zhang, Thomas T. Nguyen, Narender R. Gavva, Scott Harried, Sonya G. Lehto, Jennifer R. Allen, Holger Monenschein, Daniel B. Horne, Vijay Keshav Gore, Wenge Zhong, Kaustav Biswas
Publikováno v:
Journal of medicinal chemistry. 61(18)
Transient-receptor-potential melastatin 8 (TRPM8), the predominant mammalian cold-temperature thermosensor, is a nonselective cation channel expressed in a subpopulation of sensory neurons in the peripheral nervous system, including nerve circuitry i
Autor:
Kui Chen, Daniel La, Michael D. Bartberger, Russell Graceffa, Thomas T. Nguyen, Tisha San Miguel, E. Allen Sickmier, Ryan Brown, Vivian S. W. Li, Stephen J. Wood, Lewis D. Pennington, James Brown, Jianhua Zhang, Craig E. Masse, Holger Monenschein, Patricia Lopez, Dean Hickman, Brian K. Albrecht, May Xue, Michael Croghan, Scott Harried, Safura Babu-Khan, Yuan Cheng, Yi Luo, Martin Citron, Matthew R. Kaller, Patricia Amarante, Wenge Zhong, Paul H. Wen, Bryant Yang, Robert C. Wahl, Matthew Weiss, Chuck Kriemen, Stephen Hitchcock, Vinod F. Patel, Ted Judd, Toni Williamson
Publikováno v:
ACS Medicinal Chemistry Letters. 3:886-891
β-Secretase inhibitors are potentially disease-modifying treatments for Alzheimer's disease. Previous efforts in our laboratory have resulted in hydroxyethylamine-derived inhibitors such as 1 with low nanomolar potency against β-site amyloid precur
Autor:
Yuan Cheng, Matthew R. Kaller, Steven W. Louie, Martin Citron, Lewis D. Pennington, Daniel S. La, Matthew Weiss, Stephen J. Wood, Wenge Zhong, Michael Croghan, Toni Williamson, Scott Harried, James Brown, Kui Chen, Tisha San Miguel, Ronke Imbeah-Ampiah, Holger Monenschein, Qiufen Xue, Hongbing Huang, Patricia Lopez, Claire Rattan, Thomas Dineen, Daniel B. Horne, E. Allen Sickmier, Dean Hickman, Safura Babu-Khan, Charles Kreiman, Vivian S. W. Li, Paul H. Wen, Michael D. Bartberger, Russell Graceffa, Robert C. Wahl, Thomas T. Nguyen, Bryant Yang, Ted Judd, Joel Esmay, Vinod F. Patel, Stephen Hitchcock
Publikováno v:
Journal of Medicinal Chemistry. 55:9009-9024
A series of potent hydroxyethyl amine (HEA) derived inhibitors of β-site APP cleaving enzyme (BACE1) was optimized to address suboptimal pharmacokinetics and poor CNS partitioning. This work identified a series of benzodioxolane analogues that posse
Autor:
Paul H. Wen, Robert C. Wahl, Michael Croghan, Ronke Imbeah-Ampiah, Paul Acton, Stephen J. Wood, Charles Kreiman, Vivian S. W. Li, Qiufen Xue, Lewis D. Pennington, Safura Babu-Khan, Daniel B. Horne, Thomas Dineen, Wenge Zhong, Scott Harried, Douglas A. Whittington, Dean Hickman, James Brown, Martin Citron, Matthew Weiss, Daniel S. La, Holger Monenschein, Bryant Yang, E. Allen Sickmier, Tisha San Miguel, Robert T. Dunn, Russell Graceffa, Patricia Lopez, Toni Williamson, Hongbing Huang, Yuan Cheng, Kui Chen, Matthew R. Kaller, Michael D. Bartberger, Steven W. Louie, Hugo M. Vargas, Stephen Hitchcock, Thomas T. Nguyen, Vinod F. Patel, Ted Judd, Joel Esmay
Publikováno v:
Journal of Medicinal Chemistry. 55:9025-9044
We have previously shown that hydroxyethylamines can be potent inhibitors of the BACE1 enzyme and that the generation of BACE1 inhibitors with CYP 3A4 inhibitory activities in this scaffold affords compounds (e.g., 1) with sufficient bioavailability
Autor:
Michael Croghan, Patricia Lopez, Scott Harried, Matthew R. Kaller, Randall W. Hungate, Paul J. Reider, Wenge Zhong
Publikováno v:
The Journal of Organic Chemistry. 74:5975-5982
A di-O-TBS protected glyceraldehyde synthon was condensed with Ellman's reagent to form a bench-stable N-tert-butanesulfinyl imine 6, which served as a common intermediate for the stereoselective introduction of various R groups. The Ellman adducts w
Autor:
Kui Chen, Ryan White, Robert T. Fremeau, Stephen J. Wood, Oleg Epstein, Scott Harried, Paul H. Wen, Michael D. Bartberger, James Brown, Robert C. Wahl, Douglas A. Whittington, Robert T. Dunn, Xiao Mei Zheng, Matthew Weiss, Yuan Cheng, Patricia Lopez, Dean Hickman, Wenyuan Qian, Jian J. Chen, Vinod F. Patel, Timothy Powers, Ted Judd, Yi Luo, Ana Elena Minatti, Stephen Hitchcock, Hugo M. Vargas
BACE1 inhibition to prevent Aβ peptide formation is considered to be a potential route to a disease-modifying treatment for Alzheimer’s disease. Previous efforts in our laboratory using a combined structure- and property-based approach have result
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e2bfa91afe6b471a946b0ea848dad64
https://europepmc.org/articles/PMC4329588/
https://europepmc.org/articles/PMC4329588/
Publikováno v:
Cancer Research. 76:2964-2964
Purpose: CD20 is known to be a therapeutic antibody drug target as it is expressed on the surface of most B-cell neoplasms. Here, we assessed the anti-tumor activity of EDC9, a novel extracellular drug conjugate composed of Rituximab (a well know and
Publikováno v:
Molecular Cancer Therapeutics. 14:A125-A125
Purpose: The cardiac glycoside family of steroidal drugs has been shown to possess novel and potent antitumor activities in rodents. Yet most likely due to their cardiotoxic nature, these drugs have failed to show clinical efficacy at doses deemed sa
Autor:
Randall W. Hungate, Paul J. Reider, Matthew R. Kaller, Patricia Lopez, Michael Croghan, Scott Harried, Wenge Zhong
Publikováno v:
ChemInform. 41
A di-O-TBS protected glyceraldehyde synthon was condensed with Ellman’s reagent to form a bench-stable N-tert-butanesulfinyl imine 6, which served as a common intermediate for the stereoselective i...