A high throughput cell stretch device for investigating mechanobiology in vitro

Autor: Stephen J. P. Pratt, Christopher M. Plunkett, Guray Kuzu, Ton Trinh, Joshua Barbara, Paula Choconta, Doug Quackenbush, Truc Huynh, Anders Smith, S. Whitney Barnes, Joel New, James Pierce, John R. Walker, James Mainquist, Frederick J. King, Jimmy Elliott, Scott Hammack, Rebekah S. Decker

Publikováno v: APL Bioengineering, Vol 8, Iss 2, Pp 026129-026129-13 (2024)

Mechanobiology is a rapidly advancing field, with growing evidence that mechanical signaling plays key roles in health and disease. To accelerate mechanobiology-based drug discovery, novel in vitro systems are needed that enable mechanical perturbati

Externí odkaz: https://doaj.org/article/aabc65c393f942c5934f91911c5a8d09

A high-throughput 3D cantilever array to model airway smooth muscle hypercontractility in asthma

Autor: Pranjali Beri, Christopher Plunkett, Joshua Barbara, Chien-Cheng Shih, S. Whitney Barnes, Olivia Ross, Paula Choconta, Ton Trinh, Bella Litvin, John Walker, Minhua Qiu, Scott Hammack, Erin Toyama

Asthma is often characterized by tissue-level mechanical phenotypes that include remodeling of the airway and an increase in airway tightening driven by the underlying smooth muscle. Existing therapies only provide symptom relief and do not improve t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::054f78fd4898f539c9dd5e961dfdd3c7
https://doi.org/10.1101/2022.10.25.513767

GPR68 Senses Flow and Is Essential for Vascular Physiology

Autor: Bryan A. Laffitte, Jingyuan Li, Matt Petrus, Linda Grimaud, Keiko Nonomura, James Kevin Mainquist, Stuart M. Cahalan, Jayanti Mathur, Van Lee, Emilie Vessières, Yan Xu, Fu-Li Xiang, Julie Favre, Ardem Patapoutian, Daniel Henrion, Jie Xu, Laura Bordone, Anthony P. Orth, Allain G. Francisco, Shu Chien, Shang Ma, Viktor Lukacs, Scott Hammack, John R. Walker, Michael Bandell

Publikováno v: Cell, vol 173, iss 3
Xu, Jie; Mathur, Jayanti; Vessières, Emilie; Hammack, Scott; Nonomura, Keiko; Favre, Julie; et al.(2018). GPR68 Senses Flow and Is Essential for Vascular Physiology.. Cell, 173(3), 762-775.e16. doi: 10.1016/j.cell.2018.03.076. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/6bx4m237
The Journal of General Physiology
Cell
Cell, Elsevier, 2018, 173, pp.762-775.e16

International audience; Mechanotransduction plays a crucial role in vascular biology. One example of this is the local regulation ofvascular resistance via flow-mediated dilation (FMD). Impairment of this process is a hallmark of endothelial dysfunct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b566ce433a17a215e87c728b68cf1e4
https://escholarship.org/uc/item/6bx4m237