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Autor:
Giorgio Ottaviani, Scott Hackford, Georg Schmitt, Jianxun Xie, Juergen Funk, Paul Barrow, Loris Villabruna, Martin Bopst, Noel Downes
Publikováno v:
Regulatory Toxicology and Pharmacology. 95:339-347
This paper describes the characterization of male- and female-mediated effects in a standard ICH rat fertility and early embryonic development study with a discontinued clinical small molecule. In the standard study, the test item had no effect on th