Výsledky vyhledávání - "Scott H. Dickerson"

Supplementary Methods, Table 1, Figures 1-9 from Combinations of BRAF, MEK, and PI3K/mTOR Inhibitors Overcome Acquired Resistance to the BRAF Inhibitor GSK2118436 Dabrafenib, Mediated by NRAS or MEK Mutations

Autor: Tona M. Gilmer, Li Liu, Sylvie G. Laquerre, Scott H. Dickerson, Kimberly N. Smitheman, Ashley M. Hughes, Maureen R. Bleam, Vivian Zhang, Stephen D. Eastman, James G. Greger

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Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::612cd6282bf70c0b319d1c53a2e6856c
https://doi.org/10.1158/1535-7163.22499103.v1

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Data from Combinations of BRAF, MEK, and PI3K/mTOR Inhibitors Overcome Acquired Resistance to the BRAF Inhibitor GSK2118436 Dabrafenib, Mediated by NRAS or MEK Mutations

Autor: Tona M. Gilmer, Li Liu, Sylvie G. Laquerre, Scott H. Dickerson, Kimberly N. Smitheman, Ashley M. Hughes, Maureen R. Bleam, Vivian Zhang, Stephen D. Eastman, James G. Greger

Recent results from clinical trials with the BRAF inhibitors GSK2118436 (dabrafenib) and PLX4032 (vemurafenib) have shown encouraging response rates; however, the duration of response has been limited. To identify determinants of acquired resistance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::342d7af81845cc3449fb50863d2f5fa4
https://doi.org/10.1158/1535-7163.c.6536067

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A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells

Autor: Edgar R, Wood, Anne T, Truesdale, Octerloney B, McDonald, Derek, Yuan, Anne, Hassell, Scott H, Dickerson, Byron, Ellis, Christopher, Pennisi, Earnest, Horne, Karen, Lackey, Krystal J, Alligood, David W, Rusnak, Tona M, Gilmer, Lisa, Shewchuk

Publikováno v: Cancer research. 64(18)

GW572016 (Lapatinib) is a tyrosine kinase inhibitor in clinical development for cancer that is a potent dual inhibitor of epidermal growth factor receptor (EGFR, ErbB-1) and ErbB-2. We determined the crystal structure of EGFR bound to GW572016. The c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::974afe7b0dd067ed9660c34bab977a18
https://pubmed.ncbi.nlm.nih.gov/15374980

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Retraction

Publikováno v: Science. 298:2327-2327

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fdd92d1c23abdea3f9ddb2a75460f951
https://doi.org/10.1126/science.298.5602.2327b

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A Stereooontrolled Approach to Tri and Tetrasubstttuted Cyclohexanones

Autor: Robert J. Chambers, P. A. Zoretic, Christopher K. Biggers, Michael S. Biggers, Scott H. Dickerson, M. L. Caspar, Byung-Chan Yu

Publikováno v: Synthetic Communications. 19:2869-2875

A series of reactions utilizing acetals 2–5 with organo cuprates was studied to determine the stereoselectivity of the 1,4-conjugate addition. A90:10 stereoselectivity was observed from the reaction of lithium or bromomagnesium divinyl cuprate with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ed4c9ea78db3541f3a5498abdec00da6
https://doi.org/10.1080/00397918908052675

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