Zobrazeno 1 - 10
of 212
pro vyhledávání: '"Scott GA"'
Autor:
Katherine R. Shaw, Rachel Sandquist, Cameron Fairclough, Jesse Black, Alexandra Fitzgerald, Jaxson T. Shaw, Scott Gallager, Jennifer Lynch
Publikováno v:
Microplastics and Nanoplastics, Vol 4, Iss 1, Pp 1-14 (2024)
Abstract Microplastics accumulate in the environment but methods to extract particles from sediment for quantification and identification often lack accuracy and reproducibility. Existing methods vary greatly and many do not achieve adequate micropla
Externí odkaz:
https://doaj.org/article/7e96e59186384b9194fbd7713919bec4
Autor:
Qi Guan, Suriya J. Aktar, Reka E. Pataky, Mariet Mathew Stephen, Maud Marques, Karen Gambaro, Kahina Rachedi, Katharina Forster, Samara Strub, David Stock, Louis de Léséleuc, Winson Y. Cheung, Stuart Peacock, Christie Farrer, Scott Gavura, Mina Tadrous, Robert C. Grant, Kelvin K. W. Chan
Publikováno v:
Current Oncology, Vol 31, Iss 6, Pp 3591-3602 (2024)
Niraparib was recently funded in Canada for the maintenance treatment of ovarian cancer following platinum-based chemotherapy. However, the drug’s safety profile in the real world remains uncertain. We conducted a cohort study to describe the patie
Externí odkaz:
https://doaj.org/article/7817f7dbf22f4c7abc1ea613261997ef
Publikováno v:
International Journal of Population Data Science, Vol 9, Iss 5 (2024)
The randomized clinical trial framework has proven to be a robust way of evaluating and comparing medications and procedures for many years. The promise of measured and unmeasured balance and equipoise through randomization remains very appealing. Em
Externí odkaz:
https://doaj.org/article/6f64cc7b7fdc4eda975029e935707de6
Autor:
Pam Takhar, Marc Geirnaert, Scott Gavura, Jaclyn Beca, Rebecca E. Mercer, Avram Denburg, Caroline Muñoz, Mina Tadrous, Ambica Parmar, Francois Dionne, Darryl Boehm, Carole Chambers, Erica Craig, Maureen Trudeau, Matthew C. Cheung, Joanne Houlihan, Valerie McDonald, Petros Pechlivanoglou, Marianne Taylor, Eric Wasylenko, Wiesława Dominika Wranik, Kelvin K. W. Chan
Publikováno v:
Current Oncology, Vol 31, Iss 4, Pp 1876-1898 (2024)
Multi-criteria decision analysis (MCDA) is a value assessment tool designed to help support complex decision-making by incorporating multiple factors and perspectives in a transparent, structured approach. We developed an MCDA rating tool, consisting
Externí odkaz:
https://doaj.org/article/8cbdb12baeaa4a1eacebc73b853c3a3f
Autor:
Caroline Muñoz, Xiaochen Tai, Jessica Arias, Andrea Eisen, Munaza Chaudhry, Scott Gavura, Kelvin K. W. Chan
Publikováno v:
Current Oncology, Vol 31, Iss 3, Pp 1633-1644 (2024)
Background: Ontario publicly funds reference trastuzumab (Herceptin) and four biosimilar trastuzumab products for adjuvant treatment of HER2+ breast cancer. We assessed the real-world safety and effectiveness of biosimilar trastuzumab compared to Her
Externí odkaz:
https://doaj.org/article/d807639d5b19417a82cf897cac5c9fb4
Autor:
Scott Gardner, Yibo Jin, Paul K. Fyfe, Tomas B. Voisin, Junel Sotolongo Bellón, Elizabeth Pohler, Jacob Piehler, Ignacio Moraga, Doryen Bubeck
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract IL-11 and IL-6 activate signalling via assembly of the cell surface receptor gp130; however, it is unclear how signals are transmitted across the membrane to instruct cellular responses. Here we solve the cryoEM structure of the IL-11 recept
Externí odkaz:
https://doaj.org/article/bbc396d2171b448a8f4b408bf1d66f66
Publikováno v:
International Journal of Corporate Social Responsibility, Vol 9, Iss 1, Pp 1-13 (2024)
Abstract Quality standards (QS) (e.g., ISO 9001) play an important role in assuring the quality of goods and services for organizational stakeholders on a global scale. Recent work has highlighted the role of QS in communicating corporate social resp
Externí odkaz:
https://doaj.org/article/ad1a890f80694453a61ea601e746e9e4
Autor:
Katelyn R. Einloth, Scott Gayfield, Thomas McMaster, Alexander Didier, Lance Dworkin, Justin Fortune Creeden
Publikováno v:
BioImpacts, Vol 13, Iss 6, Pp 439-455 (2023)
Introduction: Immunotherapy has revolutionized how cancer is treated. Many of these immunotherapies rely on ex vivo expansion of immune cells, classically T cells. Still, several immunological obstacles remain, including tumor impermeability by immun
Externí odkaz:
https://doaj.org/article/108cbecef2d7450cb6830151afab2483
Autor:
Brandon Lu, Wei Fang Dai, Ruth Croxford, Wanrudee Isaranuwatchai, Jaclyn Beca, Ines B. Menjak, Teresa M. Petrella, Nicole Mittmann, Craig C. Earle, Scott Gavura, Rebecca E. Mercer, Timothy P. Hanna, Kelvin K. W. Chan
Publikováno v:
Cancer Medicine, Vol 12, Iss 10, Pp 11451-11461 (2023)
Abstract Background The efficacy‐effectiveness gap between randomized trial and real‐world evidence regarding the clinical benefit of ipilimumab for metastatic melanoma (MM) has been well characterized by previous literature, consistent with init
Externí odkaz:
https://doaj.org/article/f0604d85f42d4d3396b6316504533bac
Autor:
Ambica Parmar, Wei Fang Dai, Francois Dionne, Marc Geirnaert, Avram Denburg, Tarry Ahuja, Jaclyn Beca, Sylvie Bouchard, Carole Chambers, Melissa J. Hunt, Don Husereau, Elena Lungu, Valerie McDonald, Rebecca E. Mercer, Gunita Mitera, Caroline Muñoz, Rohini Naipaul, Stuart Peacock, Tanya Potashnik, Mina Tadrous, Pam Takhar, Marianne Taylor, Maureen Trudeau, Danica Wasney, Scott Gavura, Kelvin K. W. Chan
Publikováno v:
Current Oncology, Vol 30, Iss 4, Pp 3776-3786 (2023)
The Canadian Real-world Evidence for Value of Cancer Drugs (CanREValue) collaboration developed an MCDA rating tool to assess and prioritize potential post-market real-world evidence (RWE) questions/uncertainties emerging from public drug funding dec
Externí odkaz:
https://doaj.org/article/4fb575f2c14545e7887f622958f92f21