Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Scott G. Kitchen"'
Autor:
Jason Murray, Teresa Einhaus, Rasika Venkataraman, Stefan Radtke, Anjie Zhen, Mayra A. Carrillo, Scott G. Kitchen, Christopher W. Peterson, Hans-Peter Kiem
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 30, Iss , Pp 276-287 (2023)
Hematopoietic stem cell gene therapy has been successfully used for a number of genetic diseases and is also being explored for HIV. However, toxicity of the conditioning regimens has been a major concern. Here we compared current conditioning approa
Externí odkaz:
https://doaj.org/article/3a1ba5b791194c6d9f5f185577ce78a5
Autor:
Ellie Taus, Christian Hofmann, F. Javier Ibarrondo, Laura S. Gong, Mary Ann Hausner, Jennifer A. Fulcher, Paul Krogstad, Scott G. Kitchen, Kathie G. Ferbas, Nicole H. Tobin, Anne W. Rimoin, Grace M. Aldrovandi, Otto O. Yang
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionWhile antibodies raised by SARS-CoV-2 mRNA vaccines have had compromised efficacy to prevent breakthrough infections due to both limited durability and spike sequence variation, the vaccines have remained highly protective against severe
Externí odkaz:
https://doaj.org/article/66aeb12b28a040f5955b5f429b34efbb
Autor:
Wenli Mu, Valerie Rezek, Heather Martin, Mayra A. Carrillo, Shallu Tomer, Philip Hamid, Miguel A. Lizarraga, Tristan D. Tibbe, Otto O. Yang, Beth D. Jamieson, Scott G. Kitchen, Anjie Zhen
Publikováno v:
JCI Insight, Vol 7, Iss 22 (2022)
A hallmark of HIV-1 infection is chronic inflammation, even in patients treated with antiretroviral therapy (ART). Chronic inflammation drives HIV-1 pathogenesis, leading to loss of CD4+ T cells and exhaustion of antiviral immunity. Therefore, strate
Externí odkaz:
https://doaj.org/article/ccbac288cbda4f758e65fea1428803d6
Autor:
Maria Daskou, William Mu, Madhav Sharma, Hariclea Vasilopoulos, Rachel Heymans, Eleni Ritou, Valerie Rezek, Philip Hamid, Athanasios Kossyvakis, Shubhendu Sen Roy, Victor Grijalva, Arnab Chattopadhyay, Scott G. Kitchen, Alan M. Fogelman, Srinivasa T. Reddy, Theodoros Kelesidis
Publikováno v:
PLoS Pathogens, Vol 18, Iss 1 (2022)
Novel therapeutic strategies are needed to attenuate increased systemic and gut inflammation that contribute to morbidity and mortality in chronic HIV infection despite potent antiretroviral therapy (ART). The goal of this study is to use preclinical
Externí odkaz:
https://doaj.org/article/86c8fa7801b54de1b999098a4c5d396c
Autor:
Anjie Zhen, Mayra A Carrillo, Wenli Mu, Valerie Rezek, Heather Martin, Philip Hamid, Irvin S Y Chen, Otto O Yang, Jerome A Zack, Scott G Kitchen
Publikováno v:
PLoS Pathogens, Vol 17, Iss 8, p e1009895 (2021)
[This corrects the article DOI: 10.1371/journal.ppat.1009404.].
Externí odkaz:
https://doaj.org/article/918d89716afc466986f990abb5a59a66
Autor:
Anjie Zhen, Mayra A Carrillo, Wenli Mu, Valerie Rezek, Heather Martin, Philip Hamid, Irvin S Y Chen, Otto O Yang, Jerome A Zack, Scott G Kitchen
Publikováno v:
PLoS Pathogens, Vol 17, Iss 4, p e1009404 (2021)
Due to the durability and persistence of reservoirs of HIV-1-infected cells, combination antiretroviral therapy (ART) is insufficient in eradicating infection. Achieving HIV-1 cure or sustained remission without ART treatment will require the enhance
Externí odkaz:
https://doaj.org/article/faeeeee9e47a4f8c816035cdbb51a600
Autor:
Isaac M. Barber-Axthelm, Valerie Barber-Axthelm, Kai Yin Sze, Anjie Zhen, Gajendra W. Suryawanshi, Irvin S.Y. Chen, Jerome A. Zack, Scott G. Kitchen, Hans-Peter Kiem, Christopher W. Peterson
Publikováno v:
JCI Insight, Vol 6, Iss 1 (2021)
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) with CCR5– donor cells is the only treatment known to cure HIV-1 in patients with underlying malignancy. This is likely due to a donor cell–mediated graft-versus-host effect targeting
Externí odkaz:
https://doaj.org/article/113afdd7adba44389c9032150f25a7e3
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
The HIV reservoir remains to be a difficult barrier to overcome in order to achieve a therapeutic cure for HIV. Several strategies have been developed to purge the reservoir, including the “kick and kill” approach, which is based on the notion th
Externí odkaz:
https://doaj.org/article/36a68087108845eeac6dae14288c8ba7
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
HIV and cancer remain prevailing sources of morbidity and mortality worldwide. There are current efforts to discover novel therapeutic strategies for the treatment or cure of these diseases. Humanized mouse models provide the investigative tool to st
Externí odkaz:
https://doaj.org/article/7275bf8d7cfc4f59ae6da0267cf847ad
Autor:
Anjie Zhen, Christopher W Peterson, Mayra A Carrillo, Sowmya Somashekar Reddy, Cindy S Youn, Brianna B Lam, Nelson Y Chang, Heather A Martin, Jonathan W Rick, Jennifer Kim, Nick C Neel, Valerie K Rezek, Masakazu Kamata, Irvin S Y Chen, Jerome A Zack, Hans-Peter Kiem, Scott G Kitchen
Publikováno v:
PLoS Pathogens, Vol 14, Iss 3, p e1006891 (2018)
[This corrects the article DOI: 10.1371/journal.ppat.1006753.].
Externí odkaz:
https://doaj.org/article/e5944840550840ada1cfc5ed1d1077e8