Zobrazeno 1 - 10
of 428
pro vyhledávání: '"Scott G Franzblau"'
Autor:
Murali Kumarasamy, Panneerselvam Theivendren, Rousso Govindarajan, Scott G Franzblau, Kirthiga Ramalingam
Publikováno v:
Journal of Pharmacy and Bioallied Sciences, Vol 4, Iss 3, Pp 207-211 (2012)
Aim: A novel series of N-nitroso-3-(substituted phenylimino)-indolin-2-one 3a-h was synthesized and tested for carcinogenic effects. Materials and Methods: The synthesized pyrazole derivatives′ chemical structures were proved by means of their infr
Externí odkaz:
https://doaj.org/article/cde17968380f4bc9a70efea059954883
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138436 (2015)
Several enzymes involved in central carbon metabolism and gluconeogenesis play a critical role in survival and pathogenesis of Mycobacterium tuberculosis (Mtb). The only known functional fructose 1,6-bisphosphatase (FBPase) in Mtb is encoded by the g
Externí odkaz:
https://doaj.org/article/0563752f75f3470cafea4c0517be3c0f
Autor:
Fernando R Pavan, Gustavo V Poelhsitz, Lucas V P da Cunha, Marilia I F Barbosa, Sergio R A Leite, Alzir A Batista, Sang H Cho, Scott G Franzblau, Mariana S de Camargo, Flávia A Resende, Eliana A Varanda, Clarice Q F Leite
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64242 (2013)
Rifampicin, discovered more than 50 years ago, represents the last novel class of antibiotics introduced for the first-line treatment of tuberculosis. Drugs in this class form part of a 6-month regimen that is ineffective against MDR and XDR TB, and
Externí odkaz:
https://doaj.org/article/e703023b58f14816a09d1ac4dbcf4582
Autor:
Sean Ekins, Robert C Reynolds, Scott G Franzblau, Baojie Wan, Joel S Freundlich, Barry A Bunin
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63240 (2013)
High-throughput screening (HTS) in whole cells is widely pursued to find compounds active against Mycobacterium tuberculosis (Mtb) for further development towards new tuberculosis (TB) drugs. Hit rates from these screens, usually conducted at 10 to 2
Externí odkaz:
https://doaj.org/article/efd55384d95a4a5ab5862d98b6bb7323
Autor:
Giovanna Poce, Robert H Bates, Salvatore Alfonso, Martina Cocozza, Giulio Cesare Porretta, Lluís Ballell, Joaquin Rullas, Fátima Ortega, Alessandro De Logu, Emanuela Agus, Valentina La Rosa, Maria Rosalia Pasca, Edda De Rossi, Baojie Wae, Scott G Franzblau, Fabrizio Manetti, Maurizio Botta, Mariangela Biava
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56980 (2013)
1,5-Diphenyl pyrroles were previously identified as a class of compounds endowed with high in vitro efficacy against M. tuberculosis. To improve the physical chemical properties and drug-like parameters of this class of compounds, a medicinal chemist
Externí odkaz:
https://doaj.org/article/bf9c34f1442c4f31b95344a3fe0da5ce
Autor:
So Young Lee, Gauri S. Shetye, So-Ri Son, Hyun Lee, Larry L. Klein, Jeffrey K. Yoshihara, Rui Ma, Scott G. Franzblau, Sanghyun Cho, Dae Sik Jang
Publikováno v:
Plants, Vol 12, Iss 1, p 34 (2022)
The fruits of Amomun tsao-ko (Chinese black cardamom; Zingiberaceae) contain an abundance of essential oils, which have previously demonstrated significant antimicrobial activity. In our preliminary search for natural anti-tuberculosis agents, an ace
Externí odkaz:
https://doaj.org/article/e1ea1a2ab1ab41908c362866f3bd2841
Autor:
Hamish S. Sutherland, Peter J. Choi, Guo-Liang Lu, Anna C. Giddens, Amy S. T. Tong, Scott G. Franzblau, Christopher B. Cooper, Brian D. Palmer, William A. Denny
Publikováno v:
Pharmaceuticals, Vol 15, Iss 9, p 1125 (2022)
Pyrazolo[1,5-a]pyrimidines have been reported as potent inhibitors of mycobacterial ATP synthase for the treatment of Mycobacterium tuberculosis (M.tb). In this work, we report the design and synthesis of approximately 70 novel 3,5-diphenyl-N-(pyridi
Externí odkaz:
https://doaj.org/article/4840706fc3a44c07b8ab3fa39c285356
Autor:
Chiara Brullo, Debora Caviglia, Andrea Spallarossa, Silvana Alfei, Scott G. Franzblau, Bruno Tasso, Anna Maria Schito
Publikováno v:
Pharmaceutics, Vol 14, Iss 9, p 1770 (2022)
The pyrazole ring represents a widely applied chemical scaffold in medicinal chemistry research and we have observed that the physicochemical and biological features of highly substituted pyrazoles can be successfully improved by their encapsulation
Externí odkaz:
https://doaj.org/article/2b0075c44b6b4260b046d351c2602852
Autor:
Bhuwan Khatri Chhetri, Riya Bhanushali, Yifan Liang, Marisa R. Cepeda, Adi Kula Niradininoco, Katy Soapi, Baojie Wan, Mallique Qader, Scott G. Franzblau, Julia Kubanek
Publikováno v:
Journal of Natural Products. 86:574-581
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b87bb7edb49b562ccb798c04bde38615
https://doi.org/10.1021/acs.jnatprod.2c01003
https://doi.org/10.1021/acs.jnatprod.2c01003
Autor:
Bin, Zhou, Gauri, Shetye, Nina M, Wolf, Shao-Nong, Chen, Mallique, Qader, G Joseph, Ray, David C, Lankin, Sanghyun, Cho, Jinhua, Cheng, Joo-Won, Suh, Scott G, Franzblau, James B, McAlpine, Guido F, Pauli
Publikováno v:
Organic letters. 24(40)
Four new rufomycins, compounds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::538879218b19adaa4e2838d9e5cbe725
https://pubmed.ncbi.nlm.nih.gov/36194676
https://pubmed.ncbi.nlm.nih.gov/36194676