Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Scott F Sieg"'
Autor:
Emily R Bowman, Cheryl M Cameron, Brian Richardson, Manjusha Kulkarni, Janelle Gabriel, Morgan J Cichon, Kenneth M Riedl, Yousef Mustafa, Michael Cartwright, Brandon Snyder, Subha V Raman, David A Zidar, Susan L Koletar, Martin P Playford, Nehal N Mehta, Scott F Sieg, Michael L Freeman, Michael M Lederman, Mark J Cameron, Nicholas T Funderburg
Publikováno v:
PLoS Pathogens, Vol 16, Iss 10, p e1008869 (2020)
People with HIV (PWH) are at increased risk for atherosclerotic cardiovascular disease (ASCVD). Proportions of vascular homing monocytes are enriched in PWH; however, little is known regarding monocyte-derived macrophages (MDMs) that may drive athero
Externí odkaz:
https://doaj.org/article/09da2fd03de3473b98d561fe06dfb7c5
Autor:
Soumya Panigrahi, Bonnie Chen, Mike Fang, Daria Potashnikova, Alexey A Komissarov, Anna Lebedeva, Gillian M Michaelson, Jonathan M Wyrick, Stephen R Morris, Scott F Sieg, Mirko Paiardini, Francois J Villinger, Karem Harth, Vikram S Kashyap, Mark J Cameron, Cheryl M Cameron, Elena Vasilieva, Leonid Margolis, Souheil-Antoine Younes, Nicholas T Funderburg, David A Zidar, Michael M Lederman, Michael L Freeman
Publikováno v:
PLoS Pathogens, Vol 16, Iss 9, p e1008885 (2020)
Atherosclerotic cardiovascular disease (ASCVD) remains an important cause of morbidity in the general population and risk for ASCVD is increased approximately 2-fold in persons living with HIV infection (PLWH). This risk is linked to elevated CD8 T c
Externí odkaz:
https://doaj.org/article/ac62c44d1e6c4fe69f1c451e39acc988
Autor:
Marie R McCausland, Steven M Juchnowski, David A Zidar, Daniel R Kuritzkes, Adriana Andrade, Scott F Sieg, Michael M Lederman, Nicholas T Funderburg
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0139474 (2015)
BACKGROUND:Monocytes are increasingly implicated in the inflammatory consequences of HIV-1 disease, yet their phenotype following antiretroviral therapy (ART) initiation is incompletely defined. Here, we define more completely monocyte phenotype both
Externí odkaz:
https://doaj.org/article/c8c6001f2291478ab201c4101a06a452
Autor:
Magdalina Kalinowska, Douglas A Bazdar, Michael M Lederman, Nicholas Funderburg, Scott F Sieg
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58764 (2013)
HIV disease results in decreased IL-7 receptor expression and IL-7 responsiveness in T cells. To explore mechanisms of these deficiencies, we compared CD127 expression and IL-7 induction of P-STAT5 in T cells from HIV-infected persons with serum conc
Externí odkaz:
https://doaj.org/article/a60cdfe0954d45b28791c80749784c17
Autor:
Maura Manion, Benigno Rodriguez, Kathleen Medvik, Gareth Hardy, Clifford V Harding, Robert T Schooley, Richard Pollard, David Asmuth, Robert Murphy, Edward Barker, Kirsten E Brady, Alan Landay, Nick Funderburg, Scott F Sieg, Michael M Lederman
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30306 (2012)
Type I interferons play important roles in innate immune defense. In HIV infection, type I interferons may delay disease progression by inhibiting viral replication while at the same time accelerating disease progression by contributing to chronic im
Externí odkaz:
https://doaj.org/article/012fb500907041a3beaf9766ca3ab355
Autor:
Adam R Hersperger, Florencia Pereyra, Martha Nason, Korey Demers, Prameet Sheth, Lucy Y Shin, Colin M Kovacs, Benigno Rodriguez, Scott F Sieg, Leia Teixeira-Johnson, Debbie Gudonis, Paul A Goepfert, Michael M Lederman, Ian Frank, George Makedonas, Rupert Kaul, Bruce D Walker, Michael R Betts
Publikováno v:
PLoS Pathogens, Vol 6, Iss 5, p e1000917 (2010)
Many immune correlates of CD8(+) T-cell-mediated control of HIV replication, including polyfunctionality, proliferative ability, and inhibitory receptor expression, have been discovered. However, no functional correlates using ex vivo cells have been
Externí odkaz:
https://doaj.org/article/22391fded80246119c553a0c73d1d4db
Autor:
Nicholas Funderburg, Angel A Luciano, Wei Jiang, Benigno Rodriguez, Scott F Sieg, Michael M Lederman
Publikováno v:
PLoS ONE, Vol 3, Iss 4, p e1915 (2008)
Recently, heightened systemic translocation of microbial products was found in persons with chronic HIV infection and this was linked to immune activation and CD4(+) T cell homeostasis.We examined here the effects of microbial Toll-like receptor (TLR
Externí odkaz:
https://doaj.org/article/8fe7e872a24846cfbe46b1b2bf7350e7
Autor:
Sydney I. Ramirez, Alba Grifoni, Daniela Weiskopf, Urvi M. Parikh, Amy Heaps, Farhoud Faraji, Scott F. Sieg, Justin Ritz, Carlee Moser, Joseph J. Eron, Judith S. Currier, Paul Klekotka, Alessandro Sette, David A. Wohl, Eric S. Daar, Michael D. Hughes, Kara W. Chew, Davey M. Smith, Shane Crotty, for the Accelerating COVID-19 Therapeutic Interventions and Vaccines–2/A5401 (ACTIV-2/A5401) Study Team
Publikováno v:
JCI Insight, Vol 7, Iss 24 (2022)
Despite the widespread use of SARS-CoV-2–specific monoclonal antibody (mAb) therapy for the treatment of acute COVID-19, the impact of this therapy on the development of SARS-CoV-2–specific T cell responses has been unknown, resulting in uncertai
Externí odkaz:
https://doaj.org/article/8a5c7e6ab1d54951bb09cdce36a705c8
Autor:
Nicholas T Funderburg, Carey L Shive, Zhengyi Chen, Curtis Tatsuoka, Emily R Bowman, Chris T Longenecker, Grace A McComsey, Brian M Clagett, Dominic Dorazio, Michael L Freeman, Scott F Sieg, Daniela Moisi, Donald D Anthony, Jeffrey M Jacobson, Sharon L Stein, Leonard H Calabrese, Alan Landay, Charles Flexner, Keith W Crawford, Edmund V Capparelli, Benigno Rodriguez, Michael M Lederman
Publikováno v:
Clinical Infectious Diseases.
Background People with human immunodeficiency virus (PWH) are at increased risk for comorbidities, and plasma interleukin 6 (IL-6) levels are among the most robust predictors of these outcomes. Tocilizumab (TCZ) blocks the receptor for IL-6, inhibiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99137eface819c33179732cf5c9b7fed
https://doi.org/10.1093/cid/ciad199
https://doi.org/10.1093/cid/ciad199
Publikováno v:
Journal of leukocyte biologyREFERENCES. 112(4)
Tumor-infiltrating monocytes can mature into Macrophages that support tumor survival or that display antitumor properties. To explore mechanisms steering Macrophage maturation, we assessed the effects of supernatants from squamous cell carcinoma cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97d10b809197126f6e80d78df4a15a9b
https://pubmed.ncbi.nlm.nih.gov/35213745
https://pubmed.ncbi.nlm.nih.gov/35213745