Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Scott E. Parnell"'
Autor:
Richard C. Chang, Kara N. Thomas, Nicole A. Mehta, Kylee J. Veazey, Scott E. Parnell, Michael C. Golding
Publikováno v:
Epigenetics & Chromatin, Vol 14, Iss 1, Pp 1-16 (2021)
Abstract Background A critical question emerging in the field of developmental toxicology is whether alterations in chromatin structure induced by toxicant exposure control patterns of gene expression or, instead, are structural changes that are part
Externí odkaz:
https://doaj.org/article/d04f2596db574a03bd7ad0daa9753dd6
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 6 (2021)
Genetics are a known contributor to differences in alcohol sensitivity in humans with fetal alcohol spectrum disorders (FASDs) and in animal models. Our study profiled gene expression in gastrulation-stage embryos from two commonly used, genetically
Externí odkaz:
https://doaj.org/article/874245c3cb784d4891acb702ec9263a5
Publikováno v:
Alcohol. 106:1-9
Alcohol exposure during the formation and closure of the neural tube, or neurulation (embryonic day [E] 8-10 in mice; ∼4
Autor:
Eric W. Fish, Haley N. Mendoza‐Romero, Charlotte A. Love, Constance J. Dragicevich, Michael D. Cannizzo, Karen E. Boschen, Austin Hepperla, Jeremy M. Simon, Scott E. Parnell
Publikováno v:
Birth Defects Research. 114:1229-1243
During early development, alcohol exposure causes apoptotic cell death in discrete regions of the embryo which are associated with distinctive patterns of later-life abnormalities. In gastrulation, which occurs during the third week of human pregnanc
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0194767 (2018)
In many experiments using fetal mice, it is necessary to determine the sex of the individual fetus. However, other than genotyping for sex-specific genes, there is no convenient, reliable method of sexing mice between gestational day (GD) 16.5 and GD
Externí odkaz:
https://doaj.org/article/527e4a998fee457aa57fafb48fd77285
Publikováno v:
Reprod Toxicol
Neurulation-stage alcohol exposure (NAE; embryonic day [E] 8–10) is associated with midline craniofacial and CNS defects that likely arise from disruption of morphogen pathways, such as Sonic hedgehog (Shh). Notably, midline anomalies are also a ha
Autor:
Derek F. Burton, Oswald M. Boa‐Amponsem, Maria S. Dixon, Michael J. Hopkins, Te‐Andre Herbin, Shiquita Toney, Michael Tarpley, Blanca V. Rodriguez, Eric W. Fish, Scott E. Parnell, Gregory J. Cole, Kevin P. Williams
Publikováno v:
Journal of neuroscience research. 100(8)
Ethanol exposure during the early stages of embryonic development can lead to a range of morphological and behavioral differences termed fetal alcohol spectrum disorders (FASDs). In a zebrafish model, we have shown that acute ethanol exposure at 8-10
Loss of tumor protein 53 protects against alcohol-induced facial malformations in mice and zebrafish
Publikováno v:
Alcohol Clin Exp Res
Background Alcohol exposure during the gastrulation stage of development causes the craniofacial and brain malformations that define fetal alcohol syndrome. These malformations, such as a deficient philtrum, are exemplified by a loss of midline tissu
Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development
Publikováno v:
Journal of Clinical Investigation. 129:4393-4407
3-M primordial dwarfism is an inherited disease characterized by severe pre- and postnatal growth retardation and by mutually exclusive mutations in three genes, CUL7, OBSL1, and CCDC8. The mechanism underlying 3-M dwarfism is not clear. We showed he
Publikováno v:
Alcohol Clin Exp Res
BACKGROUND: Early gestational alcohol exposure is associated with severe craniofacial and CNS dysmorphologies and behavioral abnormalities during adolescence and adulthood. Alcohol exposure during the formation of the neural tube (gestational day [GD