Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Scott E Williams"'
AGS3 antagonizes LGN to balance oriented cell divisions and cell fate choices in mammalian epidermis
Autor:
Carlos P Descovich, Kendall J Lough, Akankshya Jena, Jessica J Wu, Jina Yom, Danielle C Spitzer, Manuela Uppalapati, Katarzyna M Kedziora, Scott E Williams
Publikováno v:
eLife, Vol 12 (2023)
Oriented cell divisions balance self-renewal and differentiation in stratified epithelia such as the skin epidermis. During peak epidermal stratification, the distribution of division angles among basal keratinocyte progenitors is bimodal, with plana
Externí odkaz:
https://doaj.org/article/a0bb50460c8e4723a4d8a41ba4e782f4
Autor:
Arad Soffer, Adnan Mahly, Krishnanand Padmanabhan, Jonathan Cohen, Orit Adir, Eidan Loushi, Yaron Fuchs, Scott E Williams, Chen Luxenburg
Publikováno v:
PLoS Biology, Vol 20, Iss 8, p e3001756 (2022)
Mitotic spindle orientation (SO) is a conserved mechanism that governs cell fate and tissue morphogenesis. In the developing epidermis, a balance between self-renewing symmetric divisions and differentiative asymmetric divisions is necessary for norm
Externí odkaz:
https://doaj.org/article/77ad6e08bca44408b36f0d0eb19a6567
Autor:
Kendall J Lough, Kevin M Byrd, Carlos P Descovich, Danielle C Spitzer, Abby J Bergman, Gerard MJ Beaudoin III, Louis F Reichardt, Scott E Williams
Publikováno v:
eLife, Vol 8 (2019)
During organogenesis, precise control of spindle orientation balances proliferation and differentiation. In the developing murine epidermis, planar and perpendicular divisions yield symmetric and asymmetric fate outcomes, respectively. Classically, d
Externí odkaz:
https://doaj.org/article/dc7ad15b2e494f039193f5433ed8fe41
Autor:
Miranda B. Carper, Scott Troutman, Bethany L. Wagner, Kevin M. Byrd, Sara R. Selitsky, Kshitij Parag-Sharma, Erin C. Henry, Weimin Li, Joel S. Parker, Stephanie A. Montgomery, John L. Cleveland, Scott E. Williams, Joseph L. Kissil, David N. Hayes, Antonio L. Amelio
Publikováno v:
Cell Reports, Vol 29, Iss 6, Pp 1660-1674.e7 (2019)
Summary: The incidence of human papilloma virus (HPV)-associated head and neck squamous cell carcinoma (HNSCC) is increasing and implicated in more than 60% of all oropharyngeal carcinomas (OPSCCs). Although whole-genome, transcriptome, and proteome
Externí odkaz:
https://doaj.org/article/3e33d72e82a34b4288b44bb3404122d7
Autor:
Carlos P Descovich, Kendall J Lough, Akankshya Jena, Jessica J Wu, Jina Yom, Danielle C Spitzer, Manuela Uppalapati, Katarzyna M Kedziora, Scott E Williams
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e691c847c33d38e4a3665a72061041a
https://doi.org/10.7554/elife.80403.sa2
https://doi.org/10.7554/elife.80403.sa2
Autor:
William Y. Kim, Benjamin G. Vincent, Scott E. Williams, Jeffrey S. Damrauer, Kevin M. Byrd, Ujjawal Manocha, Shengjie Chai, Kyle G. Stewart, Sara E. Wobker, Jordan Kardos, Lisa M. Bixby, Takanobu Utsumi, Christof C. Smith, Ryoichi Saito
High-grade urothelial cancer contains intrinsic molecular subtypes that exhibit differences in underlying tumor biology and can be divided into luminal-like and basal-like subtypes. We describe here the first subtype-specific murine models of bladder
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bdb815a3e2399cf8c0f417fd8d27ba1
https://doi.org/10.1158/0008-5472.c.6510351.v1
https://doi.org/10.1158/0008-5472.c.6510351.v1
Autor:
William Y. Kim, Benjamin G. Vincent, Scott E. Williams, Jeffrey S. Damrauer, Kevin M. Byrd, Ujjawal Manocha, Shengjie Chai, Kyle G. Stewart, Sara E. Wobker, Jordan Kardos, Lisa M. Bixby, Takanobu Utsumi, Christof C. Smith, Ryoichi Saito
Supplemental Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ae72001becabe4f158f7db566fecd8e
https://doi.org/10.1158/0008-5472.22419327
https://doi.org/10.1158/0008-5472.22419327
Autor:
William Y. Kim, Benjamin G. Vincent, Scott E. Williams, Jeffrey S. Damrauer, Kevin M. Byrd, Ujjawal Manocha, Shengjie Chai, Kyle G. Stewart, Sara E. Wobker, Jordan Kardos, Lisa M. Bixby, Takanobu Utsumi, Christof C. Smith, Ryoichi Saito
Supplemental Table 1: Flow cytometry antibody information. Supplemental Table 2: List of genes (top 10% most differentially expressed genes) used to cluster mouse cell lines from Figure 3D. Supplemental Table 3: List of genes (top 10% most differenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e63fc6758dda0ff639983e7173074ca
https://doi.org/10.1158/0008-5472.22419321
https://doi.org/10.1158/0008-5472.22419321
Autor:
William Y. Kim, Benjamin G. Vincent, Scott E. Williams, Jeffrey S. Damrauer, Kevin M. Byrd, Ujjawal Manocha, Shengjie Chai, Kyle G. Stewart, Sara E. Wobker, Jordan Kardos, Lisa M. Bixby, Takanobu Utsumi, Christof C. Smith, Ryoichi Saito
Supplemental Figure 1: Inactivation of Pten and Trp53 in Keratin 5 expressing cells does not result in bladder cancer. Supplemental Figure 2: Histologic features of BBN induced tumors. Supplemental Figure 3: Generation of KT normal urothelial cells a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b6554342c9bef676f9367485624043e
https://doi.org/10.1158/0008-5472.22419324.v1
https://doi.org/10.1158/0008-5472.22419324.v1
Publikováno v:
Methods in Molecular Biology ISBN: 9781071627518
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39241d2c7e50bc904458f524df7b6632
https://doi.org/10.1007/978-1-0716-2752-5_5
https://doi.org/10.1007/978-1-0716-2752-5_5