Zobrazeno 1 - 10
of 159
pro vyhledávání: '"Scott E Hensley"'
Autor:
Bernadeta Dadonaite, Jenny J Ahn, Jordan T Ort, Jin Yu, Colleen Furey, Annie Dosey, William W Hannon, Amy L Vincent Baker, Richard J Webby, Neil P King, Yan Liu, Scott E Hensley, Thomas P Peacock, Louise H Moncla, Jesse D Bloom
Publikováno v:
PLoS Biology, Vol 22, Iss 11, p e3002916 (2024)
H5 influenza is considered a potential pandemic threat. Recently, H5 viruses belonging to clade 2.3.4.4b have caused large outbreaks in avian and multiple nonhuman mammalian species. Previous studies have identified molecular phenotypes of the viral
Externí odkaz:
https://doaj.org/article/b551513de7f34cac99356402507891c8
Autor:
Valerie Le Sage, Jennifer E Jones, Karen A Kormuth, William J Fitzsimmons, Eric Nturibi, Gabriella H Padovani, Claudia P Arevalo, Andrea J French, Annika J Avery, Richard Manivanh, Elizabeth E McGrady, Amar R Bhagwat, Adam S Lauring, Scott E Hensley, Seema S Lakdawala
Publikováno v:
PLoS Pathogens, Vol 17, Iss 2, p e1009273 (2021)
Human-to-human transmission of influenza viruses is a serious public health threat, yet the precise role of immunity from previous infections on the susceptibility to airborne infection is still unknown. Using the ferret model, we examined the roles
Externí odkaz:
https://doaj.org/article/b545273071bd454380e3214029617bda
Autor:
Juhye M Lee, Rachel Eguia, Seth J Zost, Saket Choudhary, Patrick C Wilson, Trevor Bedford, Terry Stevens-Ayers, Michael Boeckh, Aeron C Hurt, Seema S Lakdawala, Scott E Hensley, Jesse D Bloom
Publikováno v:
eLife, Vol 8 (2019)
A longstanding question is how influenza virus evolves to escape human immunity, which is polyclonal and can target many distinct epitopes. Here, we map how all amino-acid mutations to influenza’s major surface protein affect viral neutralization b
Externí odkaz:
https://doaj.org/article/2119b3de6f684d84a4356f027f1983d8
Autor:
Nicholas C Wu, Seth J Zost, Andrew J Thompson, David Oyen, Corwin M Nycholat, Ryan McBride, James C Paulson, Scott E Hensley, Ian A Wilson
Publikováno v:
PLoS Pathogens, Vol 13, Iss 10, p e1006682 (2017)
The effectiveness of the annual influenza vaccine has declined in recent years, especially for the H3N2 component, and is a concern for global public health. A major cause for this lack in effectiveness has been attributed to the egg-based vaccine pr
Externí odkaz:
https://doaj.org/article/830f0ce391934dd8b48c3d883af37813
Publikováno v:
PLoS Pathogens, Vol 13, Iss 3, p e1006271 (2017)
Identifying viral mutations that confer escape from antibodies is crucial for understanding the interplay between immunity and viral evolution. We describe a high-throughput approach to quantify the selection that monoclonal antibodies exert on all s
Externí odkaz:
https://doaj.org/article/e6ff75ab62b2430ab1d93bff33dab506
Autor:
Susanne L Linderman, Scott E Hensley
Publikováno v:
PLoS Pathogens, Vol 12, Iss 8, p e1005806 (2016)
Human antibodies (Abs) elicited by influenza viruses often bind with a high affinity to past influenza virus strains, but paradoxically, do not bind to the viral strain actually eliciting the response. This phenomena is called 'original antigenic sin
Externí odkaz:
https://doaj.org/article/d16d5a1da5e6479ab278fa1ea8f74527
Publikováno v:
Frontiers in Microbiology, Vol 7 (2016)
Influenza virus infections are responsible for more than 250,000 deaths annually. Influenza virus isolation, propagation, and characterization protocols are critical for completing reproducible basic research studies and for generating vaccine seed s
Externí odkaz:
https://doaj.org/article/62eb11725e734178beb9980defc2900f
Evaluation of mRNA-LNP and adjuvanted protein SARS-CoV-2 vaccines in a maternal antibody mouse model
Autor:
Ross N. England, Elizabeth M. Drapeau, Mohamad-Gabriel Alameh, Reihaneh Hosseinzadeh, Drew Weissman, Scott E. Hensley
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-8 (2024)
Abstract Maternal antibodies (matAbs) protect against a myriad of pathogens early in life; however, these antibodies can also inhibit de novo immune responses against some vaccine platforms. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2
Externí odkaz:
https://doaj.org/article/ce31953d47bc4fc28564989d3cbd2e47
Autor:
Colleen Furey, Gabrielle Scher, Naiqing Ye, Lisa Kercher, Jennifer DeBeauchamp, Jeri Carol Crumpton, Trushar Jeevan, Christopher Patton, John Franks, Adam Rubrum, Mohamad-Gabriel Alameh, Steven H. Y. Fan, Anthony T. Phan, Christopher A. Hunter, Richard J. Webby, Drew Weissman, Scott E. Hensley
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract mRNA lipid nanoparticle (LNP) vaccines would be useful during an influenza virus pandemic since they can be produced rapidly and do not require the generation of egg-adapted vaccine seed stocks. Highly pathogenic avian influenza viruses from
Externí odkaz:
https://doaj.org/article/5d9fb3b6c921403890d39dcf66be7f99
Autor:
Scott E Hensley, Suman R Das, James S Gibbs, Adam L Bailey, Loren M Schmidt, Jack R Bennink, Jonathan W Yewdell
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e15190 (2011)
Drugs inhibiting the influenza A virus (IAV) neuraminidase (NA) are the cornerstone of anti-IAV chemotherapy and prophylaxis in man. Drug-resistant mutations in NA arise frequently in human isolates, limiting the therapeutic application of NA inhibit
Externí odkaz:
https://doaj.org/article/a2918f031411439db2d136499f4de716