Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Scott D. Webster"'
Autor:
Warren J. Goux, Gail V.W. Johnson, Neil R. Cooper, Yu Min Kuo, Virginia M.-Y. Lee, Joseph Rogers, B Bradt, Alex E. Roher, Ronald Strohmeyer, Libang Yang, Scott D. Webster, Yong Shen, Lih-Fen Lue
Publikováno v:
Neuroscience Letters. 305:165-168
Brain inflammation is widely documented to occur in Alzheimer's disease (AD), but its sources are still incompletely understood. Here, we present in vitro and in situ evidence that, like amyloid beta peptide (Abeta), tau, the major protein constituen
Publikováno v:
Journal of Leukocyte Biology. 67:109-116
Microglial activation has been associated with several degenerative diseases of the central nervous system (CNS). One consequence of activation is the induction of a more efficient phagocytic response, and it is therefore important to determine what
Autor:
Larry Margol, William Garzon-Rodriguez, Charles G. Glabe, Scott D. Webster, Austin J. Yang, Andrea J. Tenner
Publikováno v:
Experimental Neurology. 161:127-138
Recent studies showing that microglia internalize the amyloid beta-peptide (Abeta) suggest that these cells have the potential for clearing Abeta deposits in Alzheimer's disease, and mechanisms that regulate the removal of Abeta may therefore be of c
Publikováno v:
Neurobiology of Aging. 20:297-304
In transgenic models of Alzheimer's disease (AD) neuronal loss has not been widely observed. The loss of neurons in AD may be due to chronic activation of complement (C') by beta-amyloid (A beta). A beta has been shown to activate C' by binding to a
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1406:291-298
Experimental evidence increasingly implicates the beta-amyloid peptide in the pathogenesis of Alzheimer's disease. Beta-amyloid filaments dramatically accumulate in the neuritic plaques and vascular deposits as the result of the brain's inability to
Autor:
Joseph Rogers, Lih-Fen Lue, B Bradt, David G. Walker, Kazuhiro Terai, Andrea J. Tenner, Patrick L. McGeer, Scott D. Webster, Libuse Brachova, Neil R. Cooper
Publikováno v:
Neurobiology of Aging. 18:415-421
The membrane attack complex, C5b-9, is of considerable importance in many inflammatory reactions. It is the terminal, cytolytic component of both classical and alternative pathway activation, and its presence presupposes other potentially destructive
Autor:
B Bradt, Neil R. Cooper, Scott D. Webster, D.E. Moss, James Schultz, Lih-Fen Lue, Libuse Brachova, Joseph Rogers
Publikováno v:
Research in Immunology. 143:624-630
Publikováno v:
Developmental Biology. 146:461-472
The turnover of [32P]orthophosphate in bovine oocyte phospholipids was studied during the early stages of spontaneous meiotic maturation, and during inhibition of this process by the cAMP phosphodiesterase inhibitor 3-isobutyl-1-methyl-xanthine (IBMX
Autor:
William G. Honer, Thomas G. Beach, Paula K. Rauschkolb, Marissa Poston, David G. Walker, Pamela E. Potter, Abraham Fisher, Kathryn J. Layne, Robert A. Durham, K. Sawada, Scott D. Webster, Alex E. Roher, Amanda Newell, Sarah Scott, Lucia I. Sue, Mark R. Emmerling
Publikováno v:
Molecular Neurosurgery With Targeted Toxins ISBN: 9781588291998
There are 4 million Americans with Alzheimer’s disease (AD), and the cost of the disease to the United States is estimated at $100 billion annually (Alzheimer’s Association). Finding a cure or prevention for AD is therefore an important goal. To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ff4bf4d62e7bee3c3158cea6dc73ef6
https://doi.org/10.1007/978-1-59259-896-0_7
https://doi.org/10.1007/978-1-59259-896-0_7
Autor:
Maria I. Fonseca, Charles G. Glabe, David H. Cribbs, Andrea J. Tenner, Rakez Kayed, O. Yazan, Jun Zhou, Irma Arias Hernández, Scott D. Webster
Publikováno v:
Journal of Neuroinflammation, Vol 2, Iss 1, p 28 (2005)
Journal of Neuroinflammation
Journal of Neuroinflammation
Background Alzheimer's disease, a common dementia of the elder, is characterized by accumulation of protein amyloid deposits in the brain. Immunization to prevent this accumulation has been proposed as a therapeutic possibility, although adverse infl