Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Scott D. Pegan"'
Autor:
Elif Karaaslan, Teresa E. Sorvillo, Florine E. M. Scholte, Troy Justin O’Neal, Stephen R. Welch, Katherine A. Davies, JoAnn D. Coleman-McCray, Jessica R. Harmon, Jana M. Ritter, Scott D. Pegan, Joel M. Montgomery, Jessica R. Spengler, Christina F. Spiropoulou, Éric Bergeron
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-16 (2024)
Abstract Immunizing mice with Crimean-Congo hemorrhagic fever virus (CCHFV) nucleoprotein (NP), glycoprotein precursor (GPC), or with the GP38 domain of GPC, can be protective when the proteins are delivered with viral vectors or as a DNA or RNA vacc
Externí odkaz:
https://doaj.org/article/c721bc91b40f410a9bf386bc947427cd
Autor:
Teresa E. Sorvillo, Elif Karaaslan, Florine E. M. Scholte, Stephen R. Welch, JoAnn D. Coleman-McCray, Sarah C. Genzer, Jana M. Ritter, Heather M. Hayes, Shilpi Jain, Scott D. Pegan, Éric Bergeron, Joel M. Montgomery, Christina F. Spiropoulou, Jessica R. Spengler
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-16 (2024)
Abstract Crimean-Congo hemorrhagic fever virus (CCHFV) can cause severe human disease and is considered a WHO priority pathogen due to the lack of efficacious vaccines and antivirals. A CCHF virus replicon particle (VRP) has previously shown protecti
Externí odkaz:
https://doaj.org/article/b8ba679dc1ff413493a3bbf4a114e16c
Autor:
Aura R. Garrison, Vanessa Moresco, Xiankun Zeng, Curtis R. Cline, Michael D. Ward, Keersten M. Ricks, Scott P. Olschner, Lisa H. Cazares, Elif Karaaslan, Collin J. Fitzpatrick, Éric Bergeron, Scott D. Pegan, Joseph W. Golden
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Crimean-Congo hemorrhagic fever virus (CCHFV) is a WHO priority pathogen. Antibody-based medical countermeasures offer an important strategy to mitigate severe disease caused by CCHFV. Most efforts have focused on targeting the viral glycopr
Externí odkaz:
https://doaj.org/article/a3c8734482f549baaa8a2f4d86fd797e
Autor:
Ian A. Durie, Zahra R. Tehrani, Elif Karaaslan, Teresa E. Sorvillo, Jack McGuire, Joseph W. Golden, Stephen R. Welch, Markus H. Kainulainen, Jessica R. Harmon, Jarrod J. Mousa, David Gonzalez, Suzanne Enos, Iftihar Koksal, Gurdal Yilmaz, Hanife Nur Karakoc, Sanaz Hamidi, Cansu Albay, Jessica R. Spengler, Christina F. Spiropoulou, Aura R. Garrison, Mohammad M. Sajadi, Éric Bergeron, Scott D. Pegan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
There are currently no approved treatments for Crimean-Congo Hemorrhagic Fever Virus (CCHFV) infection. In this study, the authors structurally characterize the epitope targeted by protective non-neutralizing mouse and human antibodies and provide in
Externí odkaz:
https://doaj.org/article/ab186bd397154dcabe6fc31995264ac7
Autor:
Yifei Wu, Scott D. Pegan, David Crich, Ellison Desrochers, Edward B. Starling, Madelyn C. Hansen, Carson Booth, Lauren Nicole Mullininx, Lei Lou, Kuan Y. Chang, Zhong-Ru Xie
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 5371-5380 (2021)
Although scientists around the world have put lots of effort into the development of new treatments for COVID-19 since the outbreak, no drugs except Veklury (remdesivir) have been approved by FDA. There is an urgent need to discover some alternative
Externí odkaz:
https://doaj.org/article/310baa95dfac4bc6ae63923efa9607c0
Autor:
Yifei Wu, Scott D. Pegan, David Crich, Lei Lou, Lauren Nicole Mullininx, Edward B. Starling, Carson Booth, Andrew Edward Chishom, Kuan Y. Chang, Zhong-Ru Xie
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4397 (2023)
Papain-like protease (PLpro) is critical to COVID-19 infection. Therefore, it is a significant target protein for drug development. We virtually screened a 26,193 compound library against the PLpro of SARS-CoV-2 and identified several drug candidates
Externí odkaz:
https://doaj.org/article/d281d99627ec410ca12fe9151f971a7c
Autor:
Justin D. Shepard, Brendan T. Freitas, Sergio E. Rodriguez, Florine E. M. Scholte, Kailee Baker, Madelyn R. Hutchison, Jaron E. Longo, Holden C. Miller, Brady M. O’Boyle, Aarushi Tandon, Peng Zhao, Neil J. Grimsey, Lance Wells, Éric Bergeron, Scott D. Pegan
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
Post-translational modification of host and viral proteins by ubiquitin and ubiquitin-like proteins plays a key role in a host’s ability to mount an effective immune response. Avian species lack a ubiquitin-like protein found in mammals and other n
Externí odkaz:
https://doaj.org/article/cdb1c66c866249dda32409df4b3c5592
Autor:
Reza Nejat, Ahmad Shahir Sadr, Branden Freitas, Jackelyn Crabttree, Scott D. Pegan, Ralph A. Tripp, David Najafi
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 24, Iss 3 (2021)
Purpose: SARS-CoV-2 infection is associated with substantial mortality and high morbidity. This study tested the effect of angiotensin II type I receptor blocker, losartan, on SARS-CoV-2 replication and inhibition of the papain-like protease of the v
Externí odkaz:
https://doaj.org/article/5282cf1ba7ff4a4885a55889b1a99a94
Autor:
Florine E. M. Scholte, Jessica R. Spengler, Stephen R. Welch, Jessica R. Harmon, JoAnn D. Coleman-McCray, Brendan T. Freitas, Markus H. Kainulainen, Scott D. Pegan, Stuart T. Nichol, Éric Bergeron, Christina F. Spiropoulou
Publikováno v:
Emerging Microbes and Infections, Vol 8, Iss 1, Pp 575-578 (2019)
Externí odkaz:
https://doaj.org/article/6b04a08270d4454496726bdf76dfcda9
Autor:
Yifei Wu, David Crich, Scott D. Pegan, Lei Lou, Madelyn C. Hansen, Carson Booth, Ellison Desrochers, Lauren Nicole Mullininx, Edward B. Starling, Kuan Y. Chang, Zhong-Ru Xie
Publikováno v:
Molecules, Vol 26, Iss 24, p 7438 (2021)
An increasing number of studies have demonstrated the antiviral nature of polyphenols, and many polyphenols have been proposed to inhibit SARS-CoV or SARS-CoV-2. Our previous study revealed the inhibitory mechanisms of polyphenols against DNA polymer
Externí odkaz:
https://doaj.org/article/e30c6cbd597d486e848a3419022341cb