Výsledky vyhledávání - "Scott D. Mills"

Microspectrometric insights on the uptake of antibiotics at the single bacterial cell level

Autor: Bertrand Cinquin, Jean-Marie Pagès, Robert A. Stavenger, Elizabeth Pinet, Scott D. Mills, Laure Maigre, Matthieu Réfrégiers, Jacqueline Chevalier

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2016, 5 (1), pp.17968-17968. ⟨10.1038/srep17968⟩
Scientific Reports, 2016, 5 (1), pp.17968-17968. ⟨10.1038/srep17968⟩
Scientific Reports, 2015, 5, pp.17968. ⟨10.1038/srep17968⟩
Scientific Reports, Nature Publishing Group, 2015, 5, pp.17968. ⟨10.1038/srep17968⟩

International audience; Bacterial multidrug resistance is a significant health issue. A key challenge, particularly in Gram-negative antibacterial research, is to better understand membrane permeation of antibiotics in clinically relevant bacterial p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ffe61d0644f9c9c0f9a70e9ffbc5da5
https://hal-amu.archives-ouvertes.fr/hal-01831684

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Inhibition of Neisseria gonorrhoeae Type II Topoisomerases by the Novel Spiropyrimidinetrione AZD0914*

Autor: John P. Mueller, Gunther Kern, Shubha Sriram, David E. Ehmann, Peter Doig, Jason Thresher, Tiffany Palmer, Ning Gao, Gregory S. Basarab, Jun Fan, Scott D. Mills, Grant K. Walkup, Beth Andrews, Adam B. Shapiro

We characterized the inhibition of Neisseria gonorrhoeae type II topoisomerases gyrase and topoisomerase IV by AZD0914 (AZD0914 will be henceforth known as ETX0914 (Entasis Therapeutics)), a novel spiropyrimidinetrione antibacterial compound that is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74180a5bf31a236ccd8e4d151348403c
https://europepmc.org/articles/PMC4543657/

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Characterization ofSalmonella-Induced Filaments (Sifs) Reveals a Delayed Interaction BetweenSalmonella-Containing Vacuoles and Late Endocytic Compartments

Autor: Scott D. Mills, B. Brett Finlay, Patrick Tang, John H. Brumell

Publikováno v: Traffic. 2:643-653

Salmonella typhimurium is a facultative intracellular pathogen that colonizes host cells throughout the course of infection. A unique feature of this pathogen is its ability to enter into (invade) epithelial cells and elongate the vacuole within whic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fa6762af4d2431cd8d575fe8212d051a
https://doi.org/10.1034/j.1600-0854.2001.20907.x

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Helicobacter pylori Physiology Predicted from Genomic Comparison of Two Strains

Autor: Peter Doig, Trevor J. Trust, Gilles Carmel, Peter J. Tummino, Boudewijn L. M. de Jonge, Scott D. Mills, Brian Noonan, Eric D. Brown, Maria Uria-Nickelsen, Braydon C. Guild, Richard A. Alm, Gerald F. Vovis, Donald T. Moir

Publikováno v: Microbiology and Molecular Biology Reviews. 63:675-707

SUMMARY Helicobacter pylori is a gram-negative bacteria which colonizes the gastric mucosa of humans and is implicated in a wide range of gastroduodenal diseases. This paper reviews the physiology of this bacterium as predicted from the sequenced gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aa7099614a99ebc7ccfc2dad1124af3
https://doi.org/10.1128/mmbr.63.3.675-707.1999

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Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori

Publikováno v: Nature. 397:176-180

Helicobacter pylori, one of the most common bacterial pathogens of humans, colonizes the gastric mucosa, where it appears to persist throughout the host's life unless the patient is treated. Colonization induces chronic gastric inflammation which can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ca3dd139788314f289e01a9b94a6e57
https://doi.org/10.1038/16495

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Trafficking of Porin-Deficient Salmonella typhimurium Mutants inside HeLa Cells: ompR and envZ Mutants Are Defective for the Formation of Salmonella -Induced Filaments

Autor: B. Brett Finlay, Scott D. Mills, Sharon Ruschkowski, Murry A. Stein

Publikováno v: Infection and Immunity. 66:1806-1811

Outer membrane porin genes of Salmonella typhimurium , including ompC , ompF , and tppB , are regulated by the products of ompB , a two-component regulatory locus encoding OmpR and EnvZ. S. typhimurium ompR mutants are attenuated in mice, but to date

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bea679c428beaac11d8f517cc7e4db0f
https://doi.org/10.1128/iai.66.4.1806-1811.1998

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Yersinia enterocolitica induces apoptosis in macrophages by a process requiring functional type III secretion and translocation mechanisms and involving YopP, presumably acting as an effector protein

Autor: Anne Boland, Guy R. Cornelis, B. Brett Finlay, Patrick Van Der Smissen, Marie-Paule Sory, Corinne Kerbourch, Scott D. Mills

Publikováno v: Proceedings of the National Academy of Sciences. 94:12638-12643

Yersiniae , causative agents of plague and gastrointestinal diseases, secrete and translocate Yop effector proteins into the cytosol of macrophages, leading to disruption of host defense mechanisms. It is shown in this report that Yersinia enterocoli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::659265a2b940e5702f92cf8574d8c347
https://doi.org/10.1073/pnas.94.23.12638

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Structure guided understanding of NAD+ recognition in bacterial DNA ligases

Autor: Scott D. Mills, Grant K. Walkup, Irene Karantzeni, Ning Gao, Sushmita D. Lahiri, Rong-Fang Gu

Publikováno v: ACS chemical biology. 7(3)

NAD(+)-dependent DNA ligases (LigA) are essential bacterial enzymes that catalyze phosphodiester bond formation during DNA replication and repair processes. Phosphodiester bond formation proceeds through a 3-step reaction mechanism. In the first step

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e89f2177048f1beb17e71f69105e9b2a
https://pubmed.ncbi.nlm.nih.gov/22230472

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Comparison of Salmonella typhi and Salmonella typhimurium invasion, intracellular growth and localization in cultured human epithelial cells

Autor: B. Brett Finlay, Scott D. Mills

Publikováno v: Microbial Pathogenesis. 17:409-423

Invasion of the cultured epithelial cell lines HeLa, Henle-407, and Caco-2 (polarized and nonpolarized) by Salmonella typhi and Salmonella typhimurium were compared using conventional gentamicin invasion assays. Additionally, the mechanisms of invasi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b9d6533291fa769e9c9718e3da21dd4
https://doi.org/10.1006/mpat.1994.1086

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