Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Scott D. Kuduk"'
Autor:
Andres D. Ramirez, Anthony L. Gotter, Steven V. Fox, Pamela L. Tannenbaum, Lihang eYao, Spencer J. Tye, Terrence eMcDonald, Joseph eBrunner, Susan L. Garson, Duane R. Reiss, Scott D. Kuduk, Paul J. Coleman, Jason M. Uslaner, Robert eHodgson, Susan E. Browne, John J. Renger, Christopher J. Winrow
Publikováno v:
Frontiers in Neuroscience, Vol 7 (2013)
Dual orexin receptor antagonists (DORAs) are a potential treatment for insomnia that function by blocking both the orexin 1 and orexin 2 receptors. The objective of the current study was to further confirm the impact of therapeutic mechanisms targeti
Externí odkaz:
https://doaj.org/article/7a637e4e89e342579deeac811d80cf1d
Autor:
Justin S. Cisar, Christine Pietsch, Lindsey G. DeRatt, Edgar Jacoby, Faraz Kazmi, Colleen Keohane, Katie Legenski, Rosalie Matico, Paul Shaffer, Yvan Simonnet, Alexandra Tanner, Chao-Yuan Wang, Weixue Wang, Ricardo Attar, James P. Edwards, Scott D. Kuduk
Publikováno v:
Journal of Medicinal Chemistry. 65:11241-11256
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c5c6b618db39869a378e70ea23e59b8
https://doi.org/10.1021/acs.jmedchem.2c00788
https://doi.org/10.1021/acs.jmedchem.2c00788
Autor:
Lindsey G. DeRatt, Bart Stoops, Paul Shaffer, Angela M. Lam, Christine Espiritu, Robert Vogel, Vincent Lau, Osvaldo A. Flores, Scott D. Kuduk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9be8563853e1080a3605e868030d58bb
https://doi.org/10.2139/ssrn.4437984
https://doi.org/10.2139/ssrn.4437984
Publikováno v:
The Journal of Organic Chemistry. 86:17482-17486
Herein, a tandem approach that allows rapid access to the benzomorpholine scaffold is reported. This operationally simple method allows for valuable heterocycles to be isolated in moderate to high yields. The overall transformation consists of an ini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::879cbb9ca6e7b5aaab9aae143ca5fdbe
https://doi.org/10.1021/acs.joc.1c02166
https://doi.org/10.1021/acs.joc.1c02166
Autor:
Scott D. Kuduk, Lindsey G. DeRatt, Bart Stoops, Paul Shaffer, Angela M. Lam, Christine Espiritu, Robert Vogel, Vincent Lau, Osvaldo A. Flores, George D. Hartman
Publikováno v:
Bioorganicmedicinal chemistry letters. 72
The HBV capsid core protein serves a number of important functions in the viral life cycle enabling chronic HBV infection to persist, and therefore is a promising drug target. Interfering with capsid assembly has shown efficacy in clinical trials wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec63428738a7d2b18279c29d843bf0c8
https://pubmed.ncbi.nlm.nih.gov/35644301
https://pubmed.ncbi.nlm.nih.gov/35644301
Autor:
Edward C. Lawson, Kiran Kumar, Renee L. DesJarlais, Soyon S Hwang, Scott D. Kuduk, Lindsey G. DeRatt
Publikováno v:
Organic Letters. 22:5828-5832
A tandem one-pot reaction featuring a cross-coupling followed by an intramolecular oxetane ring opening by mild nucleophiles is reported. The overall transformation comprises a carbon-carbon bond formation along with a carbon-heteroatom bond construc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82bd011e69c2b16c957139505a218427
https://doi.org/10.1021/acs.orglett.0c01899
https://doi.org/10.1021/acs.orglett.0c01899
Publikováno v:
Organic Letters. 21:9642-9645
Oxetanes have been increasingly used as stable motifs in medicinal chemistry as well as versatile synthetic intermediates. Herein, an intramolecular ring opening of oxetane carboxamides with mild nucleophiles, such as nitrogen heterocycles, is presen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30b9593e51718244a26944b4da2b5def
https://doi.org/10.1021/acs.orglett.9b03810
https://doi.org/10.1021/acs.orglett.9b03810
Autor:
Scott D. Kuduk, Vincent Lau, Osvaldo Flores, Christine Espiritu, Robert Vogel, Angela M. Lam, George D. Hartman, Klaus Klumpp
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:2405-2409
The HBV core protein has multiple essential functions in the HBV life cycle to enable chronic HBV infection. The core protein oligomerizes to form the viral capsid, and modulation of the HBV capsid assembly process has shown clinical efficacy in earl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2146095186499eb78cb90423f3a153b7
https://doi.org/10.1016/j.bmcl.2019.05.029
https://doi.org/10.1016/j.bmcl.2019.05.029
Publikováno v:
Organic letters. 22(19)
A convergent method for the rapid preparation of substituted isocoumarins is reported. The transformation takes advantage of a spontaneous intramolecular cyclization that follows the Pd-catalyzed α-arylation of aldehydes with 2-halobenzoic esters. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90d7febcc4bbbbcd89b021c0efc90121
https://pubmed.ncbi.nlm.nih.gov/32969657
https://pubmed.ncbi.nlm.nih.gov/32969657
Publikováno v:
ACS Med Chem Lett
[Image: see text] Herein is reported a novel screening paradigm PURE (P450s under restriction) for the identification and optimization of hits as part of a hepatitis B virus (HBV) antiviral discovery program. To closely represent in vivo hepatocytes,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0176ff0b5305bc6336491bfd4cff5a59
https://europepmc.org/articles/PMC7549254/
https://europepmc.org/articles/PMC7549254/