Výsledky vyhledávání - "Scott D. Briggs"

Akademický článek

Unbiased discovery of cancer pathways and therapeutics using Pathway Ensemble Tool and Benchmark

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)

Abstract Correctly identifying perturbed biological pathways is a critical step in uncovering basic disease mechanisms and developing much-needed therapeutic strategies. However, whether current tools are optimal for unbiased discovery of relevant pa

Externí odkaz: https://doaj.org/article/37aa067c964242d3a201f09242539e89

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Akademický článek

Candida glabrata maintains two HAP1 ohnologs, HAP1A and HAP1B, for distinct roles in ergosterol gene regulation to mediate sterol homeostasis under azole and hypoxic conditions

Autor: Debasmita Saha, Justin B. Gregor, Smriti Hoda, Katharine E. Eastman, Victor A. Gutierrez-Schultz, Mindy Navarrete, Jennifer H. Wisecaver, Scott D. Briggs

Publikováno v: mSphere, Vol 9, Iss 11 (2024)

ABSTRACT Candida glabrata exhibits innate resistance to azole antifungal drugs but also has the propensity to rapidly develop clinical drug resistance. Azole drugs, which target Erg11, is one of the major classes of antifungals used to treat Candida

Externí odkaz: https://doaj.org/article/83e0839b577a446791841693a000dfe5

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Akademický článek

An expanded toolkit of drug resistance cassettes for Candida glabrata, Candida auris, and Candida albicans leads to new insights into the ergosterol pathway

Autor: Justin B. Gregor, Victor A. Gutierrez-Schultz, Smriti Hoda, Kortany M. Baker, Debasmita Saha, Madeline G. Burghaze, Cynthia Vazquez, Kendra E. Burgei, Scott D. Briggs

Publikováno v: mSphere, Vol 8, Iss 6 (2023)

ABSTRACTThe World Health Organization recently published the first list of priority fungal pathogens highlighting multiple Candida species, including Candida glabrata, Candida albicans, and Candida auris. However, prior studies in these pathogens hav

Externí odkaz: https://doaj.org/article/a97369fb80754a18aa5fd5c711b12837

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Akademický článek

Rapid, efficient auxin-inducible protein degradation in Candida pathogens

Autor: Kedric L. Milholland, Justin B. Gregor, Smriti Hoda, Soledad Píriz-Antúnez, Encarnación Dueñas-Santero, Bao Gia Vu, Krishna P. Patel, W. Scott Moye-Rowley, Carlos R. Vázquez de Aldana, Jaime Correa-Bordes, Scott D. Briggs, Mark C. Hall

Publikováno v: mSphere, Vol 8, Iss 5 (2023)

ABSTRACT A variety of inducible protein degradation (IPD) systems have been developed as powerful tools for protein functional characterization. IPD systems provide a convenient mechanism for rapid inactivation of almost any target protein of interes

Externí odkaz: https://doaj.org/article/c02846f684424772b8b8dab266c33330

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Akademický článek

Cdc14 phosphatase contributes to cell wall integrity and pathogenesis in Candida albicans

Autor: Kedric L. Milholland, Ahmed AbdelKhalek, Kortany M. Baker, Smriti Hoda, Andrew G. DeMarco, Noelle H. Naughton, Angela N. Koeberlein, Gabrielle R. Lorenz, Kartikan Anandasothy, Antonio Esperilla-Muñoz, Sanjeev K. Narayanan, Jaime Correa-Bordes, Scott D. Briggs, Mark C. Hall

Publikováno v: Frontiers in Microbiology, Vol 14 (2023)

The Cdc14 phosphatase family is highly conserved in fungi. In Saccharomyces cerevisiae, Cdc14 is essential for down-regulation of cyclin-dependent kinase activity at mitotic exit. However, this essential function is not broadly conserved and requires

Externí odkaz: https://doaj.org/article/8648e86a4d7e443ca24a03550a6e2b25

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