Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Scott D. Rose"'
Autor:
Junzhou Wang, Keith Gunderson, Scott Hansen, Joseph Dobosy, Joseph A. Walder, Katelyn Larkin, Scott D. Rose, Chris Sailor, Daniel Tsang, Mark A. Behlke, Kristin Beltz, Yu Wang, Krishnalekha Datta, Yun Bao, Aurita Menezes, Susan M. Rupp, Daniela Schrepfer, Caifu Chen, Lynette Lewis
Publikováno v:
Advances in Bioscience and Biotechnology. :497-512
We have developed a novel dual enzyme chemistry called rhAmp® SNP genotyping based on RNase H2-dependent PCR (rhPCR) that provides high signal and specificity for SNP analysis. rhAmp SNP genotyping combines a unique two-enzyme system with 3’ end b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6b27bec14182b442af8c4b7a8d17164
https://doi.org/10.4236/abb.2018.99034
https://doi.org/10.4236/abb.2018.99034
Publikováno v:
Polymerase Chain Reaction: Theory and Technology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbaf85e4250cccfdd469fc0b91ad4d13
https://doi.org/10.21775/9781912530243.09
https://doi.org/10.21775/9781912530243.09
Autor:
Junzhou Wang, Nicole Sponer, Scott D. Rose, Patrick J. Lau, Shengyao Chen, Yu Wang, Kevin Lai
Publikováno v:
Cancer Research. 79:5310-5310
Targeted next-generation sequencing (NGS) technologies serve as critical tools for cancer diagnostics. For example, individuals with pathological BRCA1 and BRCA2 (BRCA1/2) mutations have a dramatically increased risk for certain cancers, including br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba7d602dcf3df6b864d599d213f6fc91
https://doi.org/10.1158/1538-7445.am2019-5310
https://doi.org/10.1158/1538-7445.am2019-5310
Autor:
Michael J. Welsh, Christine L. Wohlford-Lenane, Scott D. Rose, Peng Jiang, Ashley M. Jacobi, Mark A. Behlke, Kim A. Lennox, Philip H. Karp, Yi Xing, Samantha R. Osterhaus, Shyam Ramachandran, Kal Praekh, Paul B. McCray
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 49:544-551
MicroRNAs (miRNAs) are increasingly recognized as important posttranscriptional regulators of gene expression, and changes in their actions can contribute to disease states. Little is understood regarding miRNA functions in the airway epithelium unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a7c4998b78878a636fc8de5860c1b30
https://doi.org/10.1165/rcmb.2012-0430oc
https://doi.org/10.1165/rcmb.2012-0430oc
Autor:
Kevin Lai, Zac Zwirko, Mirna Jarosz, Keith Bryan, Caifu Chen, Yun Bao, Madelyn Light, Ushati Das Chakravarty, Yu Zheng, Scott D. Rose
Publikováno v:
Cancer Research. 78:430-430
Diagnostic tools based on next generation sequencing are fundamentally transforming clinical oncology. However, there is a lack of adequate library preparation strategies for highly degraded, clinically relevant samples, such as cell-free DNA (cfDNA)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::194bd7f9ec916dee7995828fd4f5bee2
https://doi.org/10.1158/1538-7445.am2018-430
https://doi.org/10.1158/1538-7445.am2018-430
Autor:
Michael A. Collingwood, Scott D. Rose, Marc-André Dansereau, Louis Doré-Savard, Philippe Sarret, Mark A. Behlke, Nicolas Beaudet, Kim A. Lennox, Geneviève Roussy
Publikováno v:
Molecular Therapy. 16(7):1331-1339
RNA interference (RNAi) is gaining acceptance as a potential therapeutic strategy against peripheral disease, and several clinical trials are already underway with 21-mer small-interfering RNA (siRNA) as the active pharmaceutical agent. However, for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d000e8cbe55e2d7dd85e0cb8a551b1b
Autor:
Merete T. Wiiger, Mohammad Amarzguioui, Michael A. Collingwood, Chris Hillier, John J. Rossi, Mark A. Behlke, Lingyan Huang, Harris S. Soifer, Scott D. Rose
Publikováno v:
Oligonucleotides. 18:187-200
Dicer-substrate small interfering RNAs (DsiRNAs) are synthetic RNA duplexes that are processed by Dicer into 21-mer species and show improved potency as triggers of RNA interference, particularly when used at low dose. Chemical modification patterns
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f61404f3e7fae0c184de41ca2d1b2237
https://doi.org/10.1089/oli.2008.0123
https://doi.org/10.1089/oli.2008.0123
Autor:
Joseph A. Walder, Bernardo G. Moreira, Kim A. Lennox, Scott D. Rose, Maegan J. Johnson, John M. Dagle, Mark A. Behlke, Cherisa A. Fletcher, Jaime L. Sabel, Andrei Laikhter
Publikováno v:
Oligonucleotides. 16:26-42
A wide variety of modified oligonucleotides have been tested as antisense agents. Each chemical modification produces a distinct profile of potency, toxicity, and specificity. Novel cationic phosphoramidate-modified antisense oligonucleotides have be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8b59ec11a407381a98922b1ef517b2e
https://doi.org/10.1089/oli.2006.16.26
https://doi.org/10.1089/oli.2006.16.26
Publikováno v:
Nature Biotechnology. 23:222-226
RNA interference (RNAi) is the process of sequence-specific post-transcriptional gene silencing triggered by double-stranded RNAs. In attempts to identify RNAi triggers that effectively function at lower concentrations, we found that synthetic RNA du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53cf678492a0713496416a5177849d12
https://doi.org/10.1038/nbt1051
https://doi.org/10.1038/nbt1051
Publikováno v:
Journal of Biological Chemistry. 276:44018-44026
The 100-base pair ELA1 transcriptional enhancer drives high level transcription to pancreatic acinar cells of transgenic mice and in transfected pancreatic acinar cells in culture. The A element within the enhancer is the sole positively acting eleme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b420826bc4c8c511330d4e9013becd79
https://doi.org/10.1074/jbc.m106264200
https://doi.org/10.1074/jbc.m106264200