Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Scott D Seiwert"'
Autor:
Scott D. Seiwert, Sharlene Lim, Karl Kossen, Bill Bradford, Pete Ruminiski, David Griggs, Marshall Michener, Ramachandran Radhakrishnan, Caralee Schaefer
Publikováno v:
Idiopathic interstitial pneumonias.
Introduction: IPF is a fatal orphan fibrotic lung disease for which next generation treatments are urgently needed. RGD-binding integrins are an attractive therapeutic target involved in TGF-b activation, fibroblast migration, and myofibroblast survi
Autor:
Scott D. Seiwert, Karl Kossen, John B. Nicholas, Jyanwei Liu, Caralee Schaefer, Brad O. Buckman, Lea Huang, Donald Ruhrmund, Sharlene Lim, Lisa Hooi, Leonid Beigelman, Lin Pan, Vladimir Serebryany, Sarah K. Stevens, Srikonda Sastry, Shawn Misialek, Sophia Yap, Ravi Rajagopalan, Natalia Aleskovski
Publikováno v:
Antimicrobial Agents and Chemotherapy. 61
The current paradigm for the treatment of chronic hepatitis C virus (HCV) infection involves combinations of agents that act directly on steps of the HCV life cycle. Here we report the preclinical characteristics of ITMN-8187, a nonmacrocyclic inhibi
Autor:
Yingze Zhang, Joseph Scuirba, Fernando J. Martinez, Karl Kossen, Pirro G. Hysi, Brenda Juan-Guardela, MeiLan K. Han, Yong Huang, Carlos Flores, Mathew Barber, Shwu Fan Ma, Joe G.N. Garcia, Rekha Vij, Thomas J. Richards, Michael S. Wade, Steven M. Broderick, Naftali Kaminski, Imre Noth, Scott D. Seiwert, Jason D. Christie, Dan L. Nicolae
Publikováno v:
The Lancet Respiratory Medicine. 1:309-317
Summary Background Idiopathic pulmonary fibrosis (IPF) is a devastating disease that probably involves several genetic loci. Several rare genetic variants and one common single nucleotide polymorphism (SNP) of MUC5B have been associated with the dise
Autor:
Leonid Beigelman, Hailong Zhang, Benjamin T. Woodard, Christine Lemieux, Guy Vigers, Vlad Serebryany, Brad O. Buckman, Bin Wang, Scott D. Seiwert, Barbra J. Brandhuber, Steve Wenglowsky, Stengel Peter J, Andrews Steven W, Lawrence M. Blatt, Kennedy April L, Doherty George Andrew, John A. Josey, Joshua Ballard, Mary Geck Do, Madduru Machender R, Jiang Yutong, Kevin Ronald Condroski, Michael Lyon
Publikováno v:
Journal of Medicinal Chemistry. 57:1753-1769
HCV serine protease NS3 represents an attractive drug target because it is not only essential for viral replication but also implicated in the viral evasion of the host immune response pathway through direct cleavage of key proteins in the human inna
Autor:
David McKean, Diana Zelenika, Megan S. Devine, Christine Kim Garcia, David A. Schwartz, Keith P Smith, Philip L. Molyneaux, Yingze Zhang, Pamela Russell, Harold R. Collard, Kevin K. Brown, Elizabeth A. Regan, Barry J. Make, Hannah C. Ainsworth, Annie Pardo, Mark P. Steele, Steve D. Groshong, Gunnar Gudmundsson, Carl D. Langefeld, Naftali Kaminski, Toby M. Maher, Karl Kossen, Brian M. Freed, Yoichiro Kamatani, Moisés Selman, Weiming Zhang, Elissa Murphy, Miriam F. Moffatt, Dinesha Walek, Rachel Z. Blumhagen, David A. Lynch, Helgi J Isaksson, Cheryl Markin, Mark Lathrop, Gregory P. Cosgrove, Kenneth B. Beckman, Jerry Daniel, Janet Talbert, James E. Loyd, James D. Crapo, Paul J. Wolters, Julia Powers, Scott D. Seiwert, Brent S. Pedersen, Marvin I. Schwarz, Roland M. du Bois, Tasha E. Fingerlin, Ivana V. Yang, Williamson Z. Bradford, Athol U. Wells, Lisa Lancaster, Dong Soon Kim, Kevin F. Gibson
Publikováno v:
BMC Genetics
Background Fibrotic idiopathic interstitial pneumonias (fIIP) are a group of fatal lung diseases with largely unknown etiology and without definitive treatment other than lung transplant to prolong life. There is strong evidence for the importance of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72c63e08c41470950ee27387b2e09b87
http://hdl.handle.net/10044/1/33900
http://hdl.handle.net/10044/1/33900
Autor:
Jin Hong, John B. Nicholas, Sharlene R. Lim, Eva Herrmann, Karl Kossen, Scott D. Seiwert, Xiaoli Qin, Patrick F. Smith, Bradford Williamson Ziegler, Christophe Sarrazin, Stefan Zeuzem, Isabel Najera, Ann Arfsten, Simone Susser, Christian M. Lange, Lisa Hooi
Publikováno v:
Antimicrobial Agents and Chemotherapy. 56:271-279
Danoprevir is a hepatitis C virus (HCV) NS3/4A protease inhibitor that promotes multi-log 10 reductions in HCV RNA when administered as a 14-day monotherapy to patients with genotype 1 chronic HCV. Of these patients, 14/37 experienced a continuous de
Autor:
Karl Kossen, Scott D. Seiwert, Sharlene R. Lim, Caralee J. Schaefer, Jiing-Huey Lin, Patrick F. Smith, Lin Pan, Bradford Williamson Ziegler
Publikováno v:
Antimicrobial Agents and Chemotherapy. 55:3125-3132
Danoprevir is a potent and selective direct-acting antiviral agent that targets the protease activity of hepatitis C virus (HCV) NS3/4A. This agent results in a significant rapid decline in HCV RNA levels when it is used in monotherapy. The present s
Autor:
Antitsa Dimitrova Stoycheva, Leonid Beigelman, Karl Kossen, P. T. Ravi Rajagopalan, Donald Ruhrmund, Guangyi Wang, Brunella Felicetti, Colin H. MacKinnon, Scott D. Seiwert, Christian A.G.N. Montalbetti, Brad O. Buckman, Debasis Das, Dorian Leo Schönfeld, Huoxing Lei, Thomas Stephen Coulter, John Barker, Jian Hong, Shawn Misialek, Lisa Hooi, Sarah E. Bailey, Xinjie Gai, Wang Xiaofang, Robert K. Y. Cheng, Richard John Mears
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:4480-4483
(1,1-Dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyridine and azolo[1,5-a]pyrimidine derivatives have been investigated as potential anti-HCV drugs. Their synthesis, HCV NS5B polymerase inhibition, and replicon activity are discussed.
Autor:
Jin Hong, Christine Lemieux, Scott D. Seiwert, Shawn Misialek, Robert Rieger, Dylan P. Hartley, Lawrence M. Blatt, Sharlene R. Lim, Kevin Ronald Condroski, Antitsa Dimitrova Stoycheva, Lin Pan, Hua Tan, Gary P. Hingorani, Leonid Beigelman, Hailong Zhang, John A. Josey, Xiaoli Qin, Karl Kossen, P. T. Ravi Rajagopalan, Mary Geck Do, Vladimir Serebryany, Sarah K. Stevens, Andrews Steven W, Jiang Yutong
Publikováno v:
Antimicrobial Agents and Chemotherapy. 52:4432-4441
Future treatments for chronic hepatitis C virus (HCV) infection are likely to include agents that target viral components directly. Here, the preclinical characteristics of ITMN-191, a peptidomimetic inhibitor of the NS3/4A protease of HCV, are descr
Autor:
Narendra K. Vaish, Christopher Pasko, Karl Kossen, Vasant Jadhav, Hong Wang, Barry Polisky, Robert D. Jenison, Scott D Seiwert, James McSwiggen
Publikováno v:
Chemistry & Biology. 11:807-815
Many reports have suggested that target-activated ribozymes hold potential value as detection reagents. We show that a "half"-ribozyme ligase is activated similarly by three unstructured oligoribonucleotides representing the major sequence variants o