Zobrazeno 1 - 10
of 161
pro vyhledávání: '"Scott D Sagel"'
Autor:
Jessica E Pittman, Hannah Noah, Hollin E Calloway, Stephanie D Davis, Margaret W Leigh, Mitchell Drumm, Scott D Sagel, Frank J Accurso, Michael R Knowles, Marci K Sontag
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0177215 (2017)
Pseudomonas aeruginosa has been suggested as a major determinant of poor pulmonary outcomes in cystic fibrosis (CF), although other factors play a role. Our objective was to investigate the association of early childhood Pseudomonas infection on diff
Externí odkaz:
https://doaj.org/article/0fb2327c92db43f1927139cc46740a49
Autor:
Eliana R. Gill, Christopher H. Goss, Scott D. Sagel, Michelle L. Wright, Sharon D. Horner, Julie A. Zuñiga
Publikováno v:
BMC Pulmonary Medicine, Vol 24, Iss 1, Pp 1-7 (2024)
Abstract Background Pulmonary exacerbations (PExs) in people with cystic fibrosis (PwCF) are associated with increased healthcare costs, decreased quality of life and the risk for permanent decline in lung function. Symptom burden, the continuous phy
Externí odkaz:
https://doaj.org/article/7e5b4af87b2b49f1952a148d765c3211
Autor:
Kenneth C Malcolm, E Michelle Nichols, Silvia M Caceres, Jennifer E Kret, Stacey L Martiniano, Scott D Sagel, Edward D Chan, Lindsay Caverly, George M Solomon, Paul Reynolds, Donna L Bratton, Jennifer L Taylor-Cousar, David P Nichols, Milene T Saavedra, Jerry A Nick
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57402 (2013)
Mycobacterium abscessus is a rapidly growing mycobacterium increasingly detected in the neutrophil-rich environment of inflamed tissues, including the cystic fibrosis airway. Studies of the immune reaction to M. abscessus have focused primarily on ma
Externí odkaz:
https://doaj.org/article/96a62966f26b4aed85d8cd8a41bed232
Autor:
Edith T Zemanick, J Kirk Harris, Brandie D Wagner, Charles E Robertson, Scott D Sagel, Mark J Stevens, Frank J Accurso, Theresa A Laguna
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e62917 (2013)
Pulmonary exacerbations (PEx), frequently associated with airway infection and inflammation, are the leading cause of morbidity in cystic fibrosis (CF). Molecular microbiologic approaches detect complex microbiota from CF airway samples taken during
Externí odkaz:
https://doaj.org/article/104336e4078546e084d8ed636e9ba635
Autor:
Edith T Zemanick, Brandie D Wagner, Scott D Sagel, Mark J Stevens, Frank J Accurso, J Kirk Harris
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e15101 (2010)
The cystic fibrosis (CF) airway microbiome is complex; polymicrobial infections are common, and the presence of fastidious bacteria including anaerobes make culture-based diagnosis challenging. Quantitative real-time PCR (qPCR) offers a culture-indep
Externí odkaz:
https://doaj.org/article/beb5211ec1c44314b6c8894daa83636c
Autor:
Theodore G. Liou, Natalia Argel, Fadi Asfour, Perry S. Brown, Barbara A. Chatfield, David R. Cox, Cori L. Daines, Dixie Durham, Jessica A. Francis, Barbara Glover, My Helms, Theresa Heynekamp, John R. Hoidal, Judy L. Jensen, Christiana Kartsonaki, Ruth Keogh, Carol M. Kopecky, Noah Lechtzin, Yanping Li, Jerimiah Lysinger, Osmara Molina, Craig Nakamura, Kristyn A. Packer, Robert Paine, III, Katie R. Poch, Alexandra L. Quittner, Peggy Radford, Abby J. Redway, Scott D. Sagel, Rhonda D. Szczesniak, Shawna Sprandel, Jennifer L. Taylor-Cousar, Jane B. Vroom, Ryan Yoshikawa, John P. Clancy, J. Stuart Elborn, Kenneth N. Olivier, Frederick R. Adler
Publikováno v:
iScience, Vol 27, Iss 3, Pp 108835- (2024)
Summary: Airway inflammation underlies cystic fibrosis (CF) pulmonary exacerbations. In a prospective multicenter study of randomly selected, clinically stable adolescents and adults, we assessed relationships between 24 inflammation-associated molec
Externí odkaz:
https://doaj.org/article/0b6e6acfca2f4e87b4dbc09bc0ef7656
Autor:
Brandie D. Wagner, Edith T. Zemanick, Scott D. Sagel, Charles E. Robertson, Mark J. Stevens, Nicole Mayer-Hamblett, George Retsch-Bogart, Bonnie W. Ramsey, J. Kirk Harris
Publikováno v:
BMC Microbiology, Vol 23, Iss 1, Pp 1-11 (2023)
Abstract Background Tobramycin inhalation solution (TIS) and chronic azithromycin (AZ) have known clinical benefits for children with CF, likely due to antimicrobial and anti-inflammatory activity. The effects of chronic AZ in combination with TIS on
Externí odkaz:
https://doaj.org/article/d5da65057c594b7ab884fe12599e5df7
Autor:
Nabeeh A. Hasan, Rebecca M. Davidson, L. Elaine Epperson, Sara M. Kammlade, Sean Beagle, Adrah R. Levin, Vinicius Calado de Moura, Joshua J. Hunkins, Natalia Weakly, Scott D. Sagel, Stacey L. Martiniano, Max Salfinger, Charles L. Daley, Jerry A. Nick, Michael Strong
Publikováno v:
Emerging Infectious Diseases, Vol 27, Iss 11, Pp 2836-2846 (2021)
Mycobacterium avium complex (MAC) species constitute most mycobacteria infections in persons with cystic fibrosis (CF) in the United States, but little is known about their genomic diversity or transmission. During 2016–2020, we performed whole-gen
Externí odkaz:
https://doaj.org/article/6a40def187f344059fc57d2a76590a8d
Autor:
Wallace B. Wee, Margaret W. Leigh, Stephanie D. Davis, Margaret Rosenfeld, Kelli M. Sullivan, Michael G. Sawras, Thomas W. Ferkol, Michael R. Knowles, Carlos Milla, Scott D. Sagel, Maimoona A. Zariwala, Eleanor Pullenayegum, Sharon D. Dell
Publikováno v:
Annals of the American Thoracic Society. 19(11)
Autor:
BreAnna Kinghorn, Margaret Rosenfeld, Erin Sullivan, Frankline Onchiri, Thomas W. Ferkol, Scott D. Sagel, Sharon D. Dell, Carlos Milla, Adam J. Shapiro, Kelli M. Sullivan, Maimoona A. Zariwala, Jessica E. Pittman, Federico Mollica, Harm A. W. M. Tiddens, Mariette Kemner-van de Corput, Michael R. Knowles, Stephanie D. Davis, Margaret W. Leigh
Publikováno v:
Annals of the American Thoracic Society. 20:539-547
Primary ciliary dyskinesia (PCD) is characterized by impaired mucociliary clearance, recurrent respiratory infections, and progressive airway damage and obstructive lung disease. While the association of ciliary ultrastructure defect/genotype with se