Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Scott D Pope"'
Autor:
Naomi H Philip, Alexandra DeLaney, Lance W Peterson, Melanie Santos-Marrero, Jennifer T Grier, Yan Sun, Meghan A Wynosky-Dolfi, Erin E Zwack, Baofeng Hu, Tayla M Olsen, Anthony Rongvaux, Scott D Pope, Carolina B López, Andrew Oberst, Daniel P Beiting, Jorge Henao-Mejia, Igor E Brodsky
Publikováno v:
PLoS Pathogens, Vol 12, Iss 10, p e1005910 (2016)
Caspases regulate cell death programs in response to environmental stresses, including infection and inflammation, and are therefore critical for the proper operation of the mammalian immune system. Caspase-8 is necessary for optimal production of in
Externí odkaz:
https://doaj.org/article/f64d18916f2d4f71922dc3bc9241243c
Autor:
Simone A Nish, Dominik Schenten, F Thomas Wunderlich, Scott D Pope, Yan Gao, Namiko Hoshi, Shuang Yu, Xiting Yan, Heung Kyu Lee, Lesley Pasman, Igor Brodsky, Brian Yordy, Hongyu Zhao, Jens Brüning, Ruslan Medzhitov
Publikováno v:
eLife, Vol 3 (2014)
Innate immune recognition is critical for the induction of adaptive immune responses; however the underlying mechanisms remain incompletely understood. In this study, we demonstrate that T cell-specific deletion of the IL-6 receptor α chain (IL-6Rα
Externí odkaz:
https://doaj.org/article/e636e10d03cd4a6ca2320352758b15b1
Autor:
Xu Zhou, Ruth A. Franklin, Miri Adler, Trevor S. Carter, Emily Condiff, Taylor S. Adams, Scott D. Pope, Naomi H. Philip, Matthew L. Meizlish, Naftali Kaminski, Ruslan Medzhitov
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(32)
Animal tissues are comprised of diverse cell types. However, the mechanisms controlling the number of each cell type within tissue compartments remain poorly understood. Here, we report that different cell types utilize distinct strategies to control
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::389665b65e86f2f4a0f23fe48b9ebbc6
https://pubmed.ncbi.nlm.nih.gov/35930670
https://pubmed.ncbi.nlm.nih.gov/35930670
Autor:
Greg Kotzbauer, Kimberly Westrich, Scott D. Pope, Marv Feldman, Jerry Penso, Adam Lustig, Robert W. Dubois
Publikováno v:
Journal of Managed Care & Specialty Pharmacy. 26:1446-1451
BACKGROUND: Accountable care organizations (ACOs) have the potential to lower costs and improve quality through incentives and coordinated care. However, the design brings with it many new challenges. One such challenge is the optimal use of pharmace
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81a4b9df3a1c469775ac52d78316307b
https://doi.org/10.18553/jmcp.2020.26.11.1446
https://doi.org/10.18553/jmcp.2020.26.11.1446
Autor:
Scott D. Pope, Ruslan Medzhitov, Jason S. Weinstein, Andrew Wang, Carmen J. Booth, Shuang Yu, Cuiling Zhang
Publikováno v:
Proceedings of the National Academy of Sciences. 116:2200-2209
Secondary hemophagocytic lymphohistiocytosis (sHLH) is a highly mortal complication associated with sepsis. In adults, it is often seen in the setting of infections, especially viral infections, but the mechanisms that underlie pathogenesis are unkno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8024b2e36637d16f19d41b1e636e957
https://doi.org/10.1073/pnas.1820704116
https://doi.org/10.1073/pnas.1820704116
Autor:
Anna Eisenstein, Brandon K. Hilliard, Scott D. Pope, Cuiling Zhang, Pranali Taskar, Daniel A. Waizman, Kavita Israni-Winger, Hui Tian, Harding H. Luan, Andrew Wang
Publikováno v:
Immunity. 55:1082-1095.e5
Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase (COX) enzymes and are ubiquitously used for their anti-inflammatory properties. However, COX inhibition alone fails to explain numerous clinical outcomes of NSAID usage. Screening c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::639e80006dd76207e0080dec0ea07c44
https://doi.org/10.1016/j.immuni.2022.04.015
https://doi.org/10.1016/j.immuni.2022.04.015
Autor:
Moshe Biton, Christopher Smillie, Aviv Regev, Zuri A. Sullivan, Ruslan Medzhitov, Noah W. Palm, William Khoury-Hanold, Andrew Wang, Kavita Israni-Winger, Bernardo S. Reis, Roham Parsa, Jaechul Lim, Naomi H. Philip, Rachel K. Zwick, Scott D. Pope, Saleh Rashed, Daniel Mucida
Publikováno v:
Science. 371
γδ T cells link immunity to nutrition Gamma delta (γδ) T cells are immune cells best known for host barrier defenses in epithelial tissues. Sullivan et al. discovered a previously unrecognized role for γδ T cells in sensing nutrient uptake in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a23e2c2d61e2519371dd7959166bd71
https://doi.org/10.1126/science.aba8310
https://doi.org/10.1126/science.aba8310
Autor:
Harvey J. Kliman, Arun R. Chavan, Liza Konnikova, Feimei Liu, Albert I. Ko, Pavithra Vijayakumar, Seth Guller, Aaron M. Ring, Akiko Iwasaki, Katherine H. Campbell, Jessica Toothaker, Hannah J. Lee, Raffaella A. Morotti, John Fournier, Scott D. Pope, Kristin M. Milano, Eric Song, Nathan D. Grubaugh, Karla M. Neugebauer, Yale Impact Team, William J. Lu-Culligan, Santos Bermejo, Shelli F. Farhadian, Edward M. Courchaine, Zhonghua Tang, Adam J. Moore, Wade L. Schulz, M. Catherine Muenker, Arnau Casanovas-Massana, Lina Irshaid, Alice Lu-Culligan, Chantal B.F. Vogels
Publikováno v:
medRxiv
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
Pregnant women appear to be at increased risk for severe outcomes associated with COVID-19, but the pathophysiology underlying this increased morbidity and its potential impact on the developing fetus is not well understood. In this study of pregnant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1e095d5f483330c0f46e295df28404e
https://doi.org/10.1101/2021.01.25.21250452
https://doi.org/10.1101/2021.01.25.21250452
Autor:
William Ge, Akiko Iwasaki, Yong Kong, William Khoury-Hanold, Ruslan Medzhitov, Jonathan Klein, Priyanka Caroline Jain, Scott D. Pope, Daniel J. Kim
Publikováno v:
J Virol
Herpes simplex virus 1 (HSV-1) and HSV-2 can efficiently establish lifelong, transcriptionally silent latency states in sensory neurons to escape host detection. While host factors have previously been associated with long-range insulators in the vir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::572bc2e99509ef3e142634739e838c9b
https://europepmc.org/articles/PMC7592204/
https://europepmc.org/articles/PMC7592204/
Publikováno v:
Bio Protoc
Endogenous retroviruses (ERV) are transposable retroelements that form ~10% of the murine genome and whose family members are differentially expressed throughout embryogenesis. However, precise regulation of ERV in germ cells remains unclear. To inve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d83a648dfe63fa56a342fca298065933
https://europepmc.org/articles/PMC7854224/
https://europepmc.org/articles/PMC7854224/