Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Scott D, Zawieja"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Introduction: The bileaflet valves found in collecting lymphatic vessels and some veins are essential for maintaining a unidirectional flow, which is important for lymphatic and venous function. Under an adverse pressure gradient, the two leaflets ti
Externí odkaz:
https://doaj.org/article/4cb570c36d024590989bfb4c20d131d6
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract We previously identified two isoforms of T-type, voltage-gated calcium (Cav3) channels (Cav3.1, Cav3.2) that are functionally expressed in murine lymphatic muscle cells; however, contractile tests of lymphatic vessels from single and double
Externí odkaz:
https://doaj.org/article/d5762c773d8442d28dd06d6a5594593b
Publikováno v:
Frontiers in Physiology, Vol 13 (2023)
Introduction: The widely-used, tamoxifen-inducible, smooth muscle (SM)-specific Cre, Myh11-CreERT2, suffers from two disadvantages: 1) it is carried on the Y-chromosome and thus only effective for gene deletion in male mice, and 2) it recombines in b
Externí odkaz:
https://doaj.org/article/11b5cdcb210a40108f1df6e4909cda7a
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Obesity and metabolic syndrome pose a significant risk for developing cardiovascular disease and remain a critical healthcare challenge. Given the lymphatic system’s role as a nexus for lipid absorption, immune cell trafficking, interstitial fluid
Externí odkaz:
https://doaj.org/article/a5390eacba6f4f2e895aa425941f9e19
Autor:
Ganesh Warthi, Jessica L. Faulkner, Jaser Doja, Amr R. Ghanam, Pan Gao, Allison C. Yang, Orazio J. Slivano, Candee T. Barris, Taylor C. Kress, Scott D. Zawieja, Susan H. Griffin, Xiaoling Xie, Alan Ashworth, Christine K. Christie, William B. Bryant, Ajay Kumar, Michael J. Davis, Xiaochun Long, Lin Gan, Eric J. Belin de Chantemèle, Qing R. Lyu, Joseph M. Miano
Publikováno v:
Nature Cardiovascular Research. 1:1084-1100
Autor:
Ganesh, Warthi, Jessica L, Faulkner, Jaser, Doja, Amr R, Ghanam, Pan, Gao, Allison C, Yang, Orazio J, Slivano, Candee T, Barris, Taylor C, Kress, Scott D, Zawieja, Susan H, Griffin, Xiaoling, Xie, Alan, Ashworth, Christine K, Christie, William B, Bryant, Ajay, Kumar, Michael J, Davis, Xiaochun, Long, Lin, Gan, Eric J Belin, de Chantemèle, Qing, Lyu, Joseph M, Miano
Publikováno v:
Nat Cardiovasc Res
All current smooth muscle cell (SMC) Cre mice similarly recombine floxed alleles in vascular and visceral SMCs. Here, we present an Itga8-CreER(T2) knock-in mouse and compare its activity with a Myh11-CreER(T2) mouse. Both Cre drivers demonstrate equ
Publikováno v:
The FASEB Journal. 36
Autor:
Ganesh D. Warthi, Jessica L. Faulkner, Jaser Doja, Amr R. Ghanam, Pan Gao, Allison C. Yang, Orazio J. Slivano, Candee T. Barris, Taylor C. Kress, Scott D. Zawieja, Susan H. Griffin, Xiaoling Xie, Alan Ashworth, Christine K. Christie, William B. Bryant, Ajay Kumar, Michael J. Davis, Xiaochun Long, Lin Gan, Eric J. Belin de Chantemèle, Qing Lyu, Joseph M. Miano
All smooth muscle cell (SMC) restricted Cre mice recombine floxed alleles in vascular and visceral SMCs. We generated a new tamoxifen-inducible CreERT2 mouse, Itga8-CreERT2, and compared its activity to the widely used Myh11-CreERT2 mouse. Both CreER
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5020d4cbea63e16e8624ee3e0db4a8a
https://doi.org/10.1101/2022.02.03.479061
https://doi.org/10.1101/2022.02.03.479061
Autor:
Colin G. Nichols, Brian Saunders, Hae Jin Kim, Michael J. Davis, Bernd H. Zinselmeyer, Maria S. Remedi, Gwendalyn J. Randolph, Scott D. Zawieja, Jorge A. Castorena-Gonzalez, Peichun Gui, Min Li
Publikováno v:
The Journal of Physiology. 598:3107-3127
Key points Spontaneous contractions are essential for normal lymph transport and these contractions are exquisitely sensitive to the KATP channel activator pinacidil. KATP channel Kir6.1 and SUR2B subunits are expressed in mouse lymphatic smooth musc
Autor:
Kim H. T. To, Scott D. Zawieja, Michael J. Davis, Jorge A. Castorena-Gonzalez, Min Li, Peichun Gui
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-24 (2020)
Scientific Reports
Scientific Reports
The spontaneous contractions of collecting lymphatic vessels provide an essential propulsive force to return lymph centrally. These contractions are driven by an intrinsic electrical pacemaker, working through an unknown underlying ionic mechanism th