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of 61
pro vyhledávání: '"Scott C. Supowit"'
Publikováno v:
Physiological Reports, Vol 7, Iss 21, Pp n/a-n/a (2019)
Physiological Reports
Physiological Reports
Alpha‐calcitonin gene‐related peptide (α‐CGRP) is a 37‐amino acid neuropeptide that plays an important protective role in modulating cardiovascular diseases. Deletion of the α‐CGRP gene increases the vulnerability of the heart to pressure
Autor:
Mark C. Bowers, Khurshed A. Katki, Arundhati Rao, Michael Koehler, Parag Patel, Alvin Spiekerman, Donald J. DiPette, Scott C. Supowit
Publikováno v:
Hypertension.
Publikováno v:
Hypertension. 72
Congestive heart failure (CHF) is the leading cause of mortality in men and women world-wide, despite multiple but limited treatment modalities. Our laboratory and others have established that α-calcitonin gene-related peptide (αCGRP) plays a signi
Publikováno v:
Food Science & Nutrition
Transverse aortic constriction (TAC)-induced pressure overload (PO) causes adverse cardiac remodeling and dysfunction that progresses to heart failure (HF). The purpose of this study was to determine whether the potent antioxidant, resveratrol, signi
Autor:
Scott P. Levick, Joseph S. Janicki, Brittany A. Law, Jianping Li, Giselle C. Meléndez, Scott C. Supowit
Publikováno v:
Cardiovascular Research. 92:420-429
Substance P and neurokinin A (NKA) are sensory nerve neuropeptides encoded by the TAC1 gene. Substance P is a mast cell secretagogue and mast cells are known to play a role in adverse myocardial remodelling. Therefore, we wondered whether substance P
Autor:
Travis W. Hein, Scott C. Supowit, Prakash C. Gupta, Ian M. Dickerson, Khurshed A. Katki, Donald J. DiPette, Lih Kuo
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 301:H683-H688
In subtotal nephrectomy (SN)- and salt-induced hypertension, calcitonin gene-related peptide (CGRP) plays a compensatory role to attenuate the blood pressure increase in the absence of an increase in the neuronal synthesis and release of this peptide
Publikováno v:
Regulatory Peptides. 167:105-111
Primary cultures of adult rat dorsal root ganglia (DRG) sensory neurons were used to determine whether bradykinin and prostaglandins E1 (PGE1), E2 (PGE2) or I2 (PGI2) stimulate long-term calcitonin gene-related peptide (CGRP) mRNA accumulation and pe
Autor:
Khurshed A. Katki, Mark C. Bowers, Barbara Steficek, Gregory D. Fink, Arundhati Rao, Huawei Zhao, Donald J. DiPette, Scott C. Supowit, Parag Patel
Publikováno v:
Hypertension. 45:109-114
Calcitonin gene-related peptide is a potent vasodilator neuropeptide that is localized in perivascular sensory nerves. To determine whether alpha-calcitonin gene-related peptide possesses protective activity against hypertension-induced end organ dam
Publikováno v:
Hypertension. 38:697-700
Abstract — — Calcitonin gene-related peptide (CGRP), a potent vasodilator neuropeptide, plays a counterregulatory role in subtotal nephrectomy–salt (SN-salt)–induced hypertension, reflecting a stimulation of the efferent vasodilator function
Autor:
Scott C. Supowit, Pandu R. Gangula, Huawei Zhao, Sunil J. Wimalawansa, Donald J. DiPette, Chandrasekhar Yallampalli
Publikováno v:
Biology of Reproduction. 64:1776-1783
Calcitonin gene-related peptide (CGRP) is a potent vasodilator neuropeptide known to be involved in the regulation of vascular resistance. Several lines of evidence suggest that CGRP plays a role in the vascular adaptations that occur during normal p