Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Scott C. Ritchie"'
Autor:
Ryan Chung, Zhe Xu, Matthew Arnold, Samantha Ip, Hannah Harrison, Jessica Barrett, Lisa Pennells, Lois G. Kim, Emanuele Di Angelantonio, Ellie Paige, Scott C. Ritchie, Michael Inouye, Juliet A. Usher‐Smith, Angela M. Wood
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 15 (2023)
Background The aim of this study was to provide quantitative evidence of the use of polygenic risk scores for systematically identifying individuals for invitation for full formal cardiovascular disease (CVD) risk assessment. Methods and Results A to
Externí odkaz:
https://doaj.org/article/c219f2af3e6b407891c106228668ab08
Autor:
Scott C. Ritchie, Praveen Surendran, Savita Karthikeyan, Samuel A. Lambert, Thomas Bolton, Lisa Pennells, John Danesh, Emanuele Di Angelantonio, Adam S. Butterworth, Michael Inouye
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-15 (2023)
Abstract Metabolic biomarker data quantified by nuclear magnetic resonance (NMR) spectroscopy in approximately 121,000 UK Biobank participants has recently been released as a community resource, comprising absolute concentrations and ratios of 249 ci
Externí odkaz:
https://doaj.org/article/ed35ebeeea8940d695ceb67db7b808ab
Autor:
Carles Foguet, Yu Xu, Scott C. Ritchie, Samuel A. Lambert, Elodie Persyn, Artika P. Nath, Emma E. Davenport, David J. Roberts, Dirk S. Paul, Emanuele Di Angelantonio, John Danesh, Adam S. Butterworth, Christopher Yau, Michael Inouye
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Here, the authors present a method to build genetically personalised metabolic models across tissues to estimate individualised reaction fluxes. A fluxome-wide association study in UK Biobank identifies fluxes associated with metabolites and coronary
Externí odkaz:
https://doaj.org/article/23538818abb444f69d502c15c55eb6de
Autor:
Qin Qin Huang, Howard H. F. Tang, Shu Mei Teo, Danny Mok, Scott C. Ritchie, Artika P. Nath, Marta Brozynska, Agus Salim, Andrew Bakshi, Barbara J. Holt, Chiea Chuen Khor, Peter D. Sly, Patrick G. Holt, Kathryn E. Holt, Michael Inouye
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Some immune-mediated diseases may originate in early childhood. The authors mapped eQTLs and response eQTLs to various stimuli in neonatal myeloid cells and T cells, and revealed their potential role in immune-mediated diseases using colocalisation a
Externí odkaz:
https://doaj.org/article/4fd74a8582194eebb54003eaafc6eecf
Autor:
Yu Xu, Dragana Vuckovic, Scott C. Ritchie, Parsa Akbari, Tao Jiang, Jason Grealey, Adam S. Butterworth, Willem H. Ouwehand, David J. Roberts, Emanuele Di Angelantonio, John Danesh, Nicole Soranzo, Michael Inouye
Publikováno v:
Cell Genomics, Vol 2, Iss 1, Pp 100086- (2022)
Summary: Genetic association studies for blood cell traits, which are key indicators of health and immune function, have identified several hundred associations and defined a complex polygenic architecture. Polygenic scores (PGSs) for blood cell trai
Externí odkaz:
https://doaj.org/article/e03b3d899b854736b49b730e372f2726
Autor:
Heikki V. Sarin, Juha J. Hulmi, Youwen Qin, Michael Inouye, Scott C. Ritchie, Susan Cheng, Jeramie D. Watrous, Thien-Tu C. Nguyen, Joseph H. Lee, Zhezhen Jin, Joseph D. Terwilliger, Teemu Niiranen, Aki Havulinna, Veikko Salomaa, Kirsi H. Pietiläinen, Ville Isola, Juha P. Ahtiainen, Keijo Häkkinen, Mohit Jain, Markus Perola
Publikováno v:
Metabolites, Vol 12, Iss 10, p 928 (2022)
Weight loss and increased physical activity may promote beneficial modulation of the metabolome, but limited evidence exists about how very low-level weight loss affects the metabolome in previously non-obese active individuals. Following a weight lo
Externí odkaz:
https://doaj.org/article/c5d0eaa692334f5fb6248c6660ee3a65
Autor:
Artika P. Nath, Scott C. Ritchie, Sean G. Byars, Liam G. Fearnley, Aki S. Havulinna, Anni Joensuu, Antti J. Kangas, Pasi Soininen, Annika Wennerström, Lili Milani, Andres Metspalu, Satu Männistö, Peter Würtz, Johannes Kettunen, Emma Raitoharju, Mika Kähönen, Markus Juonala, Aarno Palotie, Mika Ala-Korpela, Samuli Ripatti, Terho Lehtimäki, Gad Abraham, Olli Raitakari, Veikko Salomaa, Markus Perola, Michael Inouye
Publikováno v:
Genome Biology, Vol 18, Iss 1, Pp 1-15 (2017)
Abstract Background Immunometabolism plays a central role in many cardiometabolic diseases. However, a robust map of immune-related gene networks in circulating human cells, their interactions with metabolites, and their genetic control is still lack
Externí odkaz:
https://doaj.org/article/e180785c8f2d4968ab0cf6652e950915
Autor:
Francine Z. Marques, Priscilla R. Prestes, Sean G. Byars, Scott C. Ritchie, Peter Würtz, Sheila K. Patel, Scott A. Booth, Indrajeetsinh Rana, Yosuke Minoda, Stuart P. Berzins, Claire L. Curl, James R. Bell, Bryan Wai, Piyush M. Srivastava, Antti J. Kangas, Pasi Soininen, Saku Ruohonen, Mika Kähönen, Terho Lehtimäki, Emma Raitoharju, Aki Havulinna, Markus Perola, Olli Raitakari, Veikko Salomaa, Mika Ala‐Korpela, Johannes Kettunen, Maree McGlynn, Jason Kelly, Mary E. Wlodek, Paul A. Lewandowski, Lea M. Delbridge, Louise M. Burrell, Michael Inouye, Stephen B. Harrap, Fadi J. Charchar
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 6 (2017)
BackgroundCardiac hypertrophy increases the risk of developing heart failure and cardiovascular death. The neutrophil inflammatory protein, lipocalin‐2 (LCN2/NGAL), is elevated in certain forms of cardiac hypertrophy and acute heart failure. Howeve
Externí odkaz:
https://doaj.org/article/f5430b2a41554e029fc2eb74411dd1ef
Autor:
Yu Xu, Scott C. Ritchie, Yujian Liang, Paul R. H. J. Timmers, Maik Pietzner, Loïc Lannelongue, Samuel A. Lambert, Usman A. Tahir, Sebastian May-Wilson, Carles Foguet, Åsa Johansson, Praveen Surendran, Artika P. Nath, Elodie Persyn, James E. Peters, Clare Oliver-Williams, Shuliang Deng, Bram Prins, Jian’an Luan, Lorenzo Bomba, Nicole Soranzo, Emanuele Di Angelantonio, Nicola Pirastu, E. Shyong Tai, Rob M. van Dam, Helen Parkinson, Emma E. Davenport, Dirk S. Paul, Christopher Yau, Robert E. Gerszten, Anders Mälarstig, John Danesh, Xueling Sim, Claudia Langenberg, James F. Wilson, Adam S. Butterworth, Michael Inouye
Publikováno v:
Xu, Y, Ritchie, S C, Liang, Y, Timmers, P R H J, Pietzner, M, Lannelongue, L, Lambert, S A, Tahir, U A, May-Wilson, S, Foguet, C, Johansson, Å, Surendran, P, Nath, A P, Persyn, E, Peters, J E, Oliver-Williams, C, Deng, S, Prins, B, Luan, J, Bomba, L, Soranzo, N, Di Angelantonio, E, Pirastu, N, Tai, E S, van Dam, R M, Parkinson, H, Davenport, E E, Paul, D S, Yau, C, Gerszten, R E, Mälarstig, A, Danesh, J, Sim, X, Langenberg, C, Wilson, J F, Butterworth, A S & Inouye, M 2023, ' An atlas of genetic scores to predict multi-omic traits ', Nature, vol. 616, no. 7955, pp. 123-131 . https://doi.org/10.1038/s41586-023-05844-9
The use of omic modalities to dissect the molecular underpinnings of common diseases and traits is becoming increasingly common. But multi-omic traits can be genetically predicted, which enables highly cost-effective and powerful analyses for studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4ad66d3a872bd064ddfd33b2ad4f8b7
https://www.pure.ed.ac.uk/ws/files/337957796/An_atlas_of_genetic_scores_to_predict_multi_omic_traits_s41586_023_05844_9.pdf
https://www.pure.ed.ac.uk/ws/files/337957796/An_atlas_of_genetic_scores_to_predict_multi_omic_traits_s41586_023_05844_9.pdf
Autor:
Ryan Chung, Zhe Xu, Matthew Arnold, Samantha Ip, Hannah Harrison, Jessica Barrett, Lisa Pennells, Lois G. Kim, Emanuele DiAngelantonio, Ellie Paige, Scott C. Ritchie, Michael Inouye, Juliet A. Usher-Smith, Angela M. Wood
BackgroundTo provide quantitative evidence of the use of polygenic risk scores (PRS) for systematically identifying individuals for invitation for full formal cardiovascular disease (CVD) risk assessment.Methods108,685 participants aged 40-69, with m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69599d238f2945156cb4348718edc9bd
https://doi.org/10.1101/2022.10.20.22281120
https://doi.org/10.1101/2022.10.20.22281120