Zobrazeno 1 - 10
of 166
pro vyhledávání: '"Scott C Blanchard"'
Autor:
Manuel F Juette, Jordan D Carelli, Emily J Rundlet, Alan Brown, Sichen Shao, Angelica Ferguson, Michael R Wasserman, Mikael Holm, Jack Taunton, Scott C Blanchard
Publikováno v:
eLife, Vol 11 (2022)
Rapid and accurate mRNA translation requires efficient codon-dependent delivery of the correct aminoacyl-tRNA (aa-tRNA) to the ribosomal A site. In mammals, this fidelity-determining reaction is facilitated by the GTPase elongation factor-1 alpha (eE
Externí odkaz:
https://doaj.org/article/8f80b5c7131340bf8719fcfe6bafffa4
Autor:
Eitan Lerner, Anders Barth, Jelle Hendrix, Benjamin Ambrose, Victoria Birkedal, Scott C Blanchard, Richard Börner, Hoi Sung Chung, Thorben Cordes, Timothy D Craggs, Ashok A Deniz, Jiajie Diao, Jingyi Fei, Ruben L Gonzalez, Irina V Gopich, Taekjip Ha, Christian A Hanke, Gilad Haran, Nikos S Hatzakis, Sungchul Hohng, Seok-Cheol Hong, Thorsten Hugel, Antonino Ingargiola, Chirlmin Joo, Achillefs N Kapanidis, Harold D Kim, Ted Laurence, Nam Ki Lee, Tae-Hee Lee, Edward A Lemke, Emmanuel Margeat, Jens Michaelis, Xavier Michalet, Sua Myong, Daniel Nettels, Thomas-Otavio Peulen, Evelyn Ploetz, Yair Razvag, Nicole C Robb, Benjamin Schuler, Hamid Soleimaninejad, Chun Tang, Reza Vafabakhsh, Don C Lamb, Claus AM Seidel, Shimon Weiss
Publikováno v:
eLife, Vol 10 (2021)
Single-molecule FRET (smFRET) has become a mainstream technique for studying biomolecular structural dynamics. The rapid and wide adoption of smFRET experiments by an ever-increasing number of groups has generated significant progress in sample prepa
Externí odkaz:
https://doaj.org/article/acccb8f6f1f1430c8cef78416466d619
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 11, p e1008293 (2020)
Molecular Dynamics (MD) simulations seek to provide atomic-level insights into conformationally dynamic biological systems at experimentally relevant time resolutions, such as those afforded by single-molecule fluorescence measurements. However, limi
Externí odkaz:
https://doaj.org/article/db0e0fee946d461b8734df83c9cbea39
Autor:
Mary McMahon, Adrian Contreras, Mikael Holm, Tamayo Uechi, Craig M Forester, Xiaming Pang, Cody Jackson, Meredith E Calvert, Bin Chen, David A Quigley, John M Luk, R Kate Kelley, John D Gordan, Ryan M Gill, Scott C Blanchard, Davide Ruggero
Publikováno v:
eLife, Vol 8 (2019)
Small nucleolar RNAs (snoRNAs) are a diverse group of non-coding RNAs that direct chemical modifications at specific residues on other RNA molecules, primarily on ribosomal RNA (rRNA). SnoRNAs are altered in several cancers; however, their role in ce
Externí odkaz:
https://doaj.org/article/049984ff3ff540b49c64893eccc6ff9f
Autor:
Vanessa A Gutzeit, Jordana Thibado, Daniel Starer Stor, Zhou Zhou, Scott C Blanchard, Olaf S Andersen, Joshua Levitz
Publikováno v:
eLife, Vol 8 (2019)
Metabotropic glutamate receptors (mGluRs) are class C, synaptic G-protein-coupled receptors (GPCRs) that contain large extracellular ligand binding domains (LBDs) and form constitutive dimers. Despite the existence of a detailed picture of inter-LBD
Externí odkaz:
https://doaj.org/article/78177d0aa6b543d28b983fdb1e6cccb3
Autor:
Erika A Riederer, Paul J Focke, Elka R Georgieva, Nurunisa Akyuz, Kimberly Matulef, Peter P Borbat, Jack H Freed, Scott C Blanchard, Olga Boudker, Francis I Valiyaveetil
Publikováno v:
eLife, Vol 7 (2018)
Membrane proteins such as ion channels and transporters are frequently homomeric. The homomeric nature raises important questions regarding coupling between subunits and complicates the application of techniques such as FRET or DEER spectroscopy. The
Externí odkaz:
https://doaj.org/article/39e3a06096de4aa7b5b9638d479f75a6
Autor:
Xiaochu Ma, Maolin Lu, Jason Gorman, Daniel S Terry, Xinyu Hong, Zhou Zhou, Hong Zhao, Roger B Altman, James Arthos, Scott C Blanchard, Peter D Kwong, James B Munro, Walther Mothes
Publikováno v:
eLife, Vol 7 (2018)
HIV-1 entry into cells requires binding of the viral envelope glycoprotein (Env) to receptor CD4 and coreceptor. Imaging of individual Env molecules on native virions shows Env trimers to be dynamic, spontaneously transitioning between three distinct
Externí odkaz:
https://doaj.org/article/ac15869e948c47c2b1fd101eeab5a88a
Autor:
F. Aaron Cruz-Navarrete, Wezley C. Griffin, Yuk-Cheung Chan, Maxwell I. Martin, Jose L. Alejo, Ryan A. Brady, S. Kundhavai Natchiar, Isaac J. Knudson, Roger B. Altman, Alanna Schepartz, Scott J. Miller, Scott C. Blanchard
Publikováno v:
ACS Central Science, Vol 10, Iss 6, Pp 1262-1275 (2024)
Externí odkaz:
https://doaj.org/article/ba1dc3cf6463484dbb80acadc7def01d
Autor:
Randall A Dass, Aishe A Sarshad, Brittany B Carson, Jennifer M Feenstra, Amanpreet Kaur, Ales Obrdlik, Matthew M Parks, Varsha Prakash, Damon K Love, Kristian Pietras, Rosa Serra, Scott C Blanchard, Piergiorgio Percipalle, Anthony M C Brown, C Theresa Vincent
Publikováno v:
PLoS Genetics, Vol 12, Iss 8, p e1006217 (2016)
Ribosome biogenesis is essential for cell growth and proliferation and is commonly elevated in cancer. Accordingly, numerous oncogene and tumor suppressor signaling pathways target rRNA synthesis. In breast cancer, non-canonical Wnt signaling by Wnt5
Externí odkaz:
https://doaj.org/article/5285d630defb47bba294796a1bfeabe4
Publikováno v:
PLoS Computational Biology, Vol 9, Iss 3, p e1003003 (2013)
Functional rearrangements in biomolecular assemblies result from diffusion across an underlying energy landscape. While bulk kinetic measurements rely on discrete state-like approximations to the energy landscape, single-molecule methods can project
Externí odkaz:
https://doaj.org/article/fd135dfba03a404f8ad2759009f9c4a5