Zobrazeno 1 - 10
of 141
pro vyhledávání: '"Scott C Baraban"'
Autor:
Brian P Grone, Maria Marchese, Kyla R Hamling, Maneesh G Kumar, Christopher S Krasniak, Federico Sicca, Filippo M Santorelli, Manisha Patel, Scott C Baraban
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151148 (2016)
Mutations in the synaptic machinery gene syntaxin-binding protein 1, STXBP1 (also known as MUNC18-1), are linked to childhood epilepsies and other neurodevelopmental disorders. Zebrafish STXBP1 homologs (stxbp1a and stxbp1b) have highly conserved seq
Externí odkaz:
https://doaj.org/article/19ac1df334b24843b09c716bf5603e9e
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Interneuron progenitor transplantation can ameliorate disease symptoms in a variety of neurological disorders. The strategy is based on transplantation of embryonic medial ganglionic eminence (MGE) progenitors. Elucidating how host brain env
Externí odkaz:
https://doaj.org/article/0b465fca1aec40edabe9fca4b0225bb9
Autor:
Ying-Jiun J Chen, Daniel Vogt, Yanling Wang, Axel Visel, Shanni N Silberberg, Cory R Nicholas, Teruko Danjo, Joshua L Pollack, Len A Pennacchio, Stewart Anderson, Yoshiki Sasai, Scott C Baraban, Arnold R Kriegstein, Arturo Alvarez-Buylla, John L R Rubenstein
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e61956 (2013)
The medial ganglionic eminence (MGE) is an embryonic forebrain structure that generates the majority of cortical interneurons. MGE transplantation into specific regions of the postnatal central nervous system modifies circuit function and improves de
Externí odkaz:
https://doaj.org/article/28e624242c63448da9124c64c01e63c9
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Impairment of development, migration, or function of inhibitory interneurons are key features of numerous circuit-based neurological disorders, such as epilepsy. From a therapeutic perspective, symptomatic treatment of these disorders often relies up
Externí odkaz:
https://doaj.org/article/07248190e8a446919df6c1186b336d79
Autor:
Aliesha Griffin, Colleen Carpenter, Jing Liu, Rosalia Paterno, Brian Grone, Kyla Hamling, Maia Moog, Matthew T. Dinday, Francisco Figueroa, Mana Anvar, Chinwendu Ononuju, Tony Qu, Scott C. Baraban
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Griffin et al used CRISPR-Cas9 to generate 40 single-gene mutant zebrafish lines representing childhood epilepsies for which they evaluated larval phenotypes using electrophysiological, behavioral, neuro-anatomical, survival and pharmacological assay
Externí odkaz:
https://doaj.org/article/bfcda728977044beb624cc6204edc73f
Autor:
Scott C. Baraban
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 7 (2021)
Danio rerio (zebrafish) are a powerful experimental model for genetic and developmental studies. Adaptation of zebrafish to study seizures was initially established using the common convulsant agent pentylenetetrazole (PTZ). Larval PTZ-exposed zebraf
Externí odkaz:
https://doaj.org/article/0d61a80864f1408c9532696489672417
Publikováno v:
iScience, Vol 24, Iss 6, Pp 102558- (2021)
Summary: STXBP1 mutations are associated with encephalopathy, developmental delay, intellectual disability, and epilepsy. While neural networks are known to operate at a critical state in the healthy brain, network behavior during pathological epilep
Externí odkaz:
https://doaj.org/article/1b3fd895552e4e51ab633cc03b8ad321
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Hemizygous mutations in the human gene encoding platelet-activating factor acetylhydrolase IB subunit alpha (Pafah1b1), also called Lissencephaly-1, can cause classical lissencephaly, a severe malformation of cortical development. Children w
Externí odkaz:
https://doaj.org/article/3b5b7da363c540d1b3dea4e151e4f974
Clemizole and trazodone are effective antiseizure treatments in a zebrafish model of STXBP1 disorder
Autor:
Maia Moog, Scott C. Baraban
Publikováno v:
Epilepsia Open. 7:504-511
CRISPR-Cas9-generated zebrafish carrying a 12 base-pair deletion in stxbpb1b, a paralog sharing 79% amino acid sequence identity with human, exhibit spontaneous electrographic seizures during larval stages of development. Zebrafish stxbp1b mutants pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dd42d4ee60519f68f6271bfedcfa438
https://doi.org/10.1002/epi4.12604
https://doi.org/10.1002/epi4.12604
Clemizole and trazodone are effective antiseizure treatments in a zebrafish model of STXBP1 disorder
Autor:
Maia Moog, Scott C. Baraban
Publikováno v:
Epilepsia open, vol 7, iss 3
ObjectiveCRISPR-Cas9-generated zebrafish carrying a 12 base-pair deletion in stxbpb1b, a paralog sharing 79% amino acid sequence identity with human, exhibit spontaneous electrographic seizures during larval stages of development. Zebrafish stxbp1b m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9af344dc2ba556d2b5bd74ae76065c82
https://escholarship.org/uc/item/4mt153k5
https://escholarship.org/uc/item/4mt153k5
