Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Scott Broadbent"'
Publikováno v:
Organic Process Research & Development. 14:612-616
The pilot-plant syntheses of 3 and 4, the core structures of a series of P2X7 antagonists are described. The sole stereogenic center in the dihydropyridinone ring was generated by catalytic desymmetrization. Selective formylation, followed by a tande
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8269a8ece29210dfa0d60e0ce23de97
https://doi.org/10.1021/op1000447
https://doi.org/10.1021/op1000447
The first asymmetric synthesis of a 4-aryl-substituted 5-carboxy-3,4-dihydropyridin-2-one derivative
Publikováno v:
Tetrahedron Letters. 51:1554-1557
A simple and practical route for the asymmetric synthesis of (S)-4-(4-fluorophenyl)-1,4,5,6-tetrahydro-6-oxo-3-pyridinecarboxylic acid (1) is presented. The procedure comprises catalytic desymmetrization of a meso-anhydride using a chiral thiourea or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f1fbf912d96d6bf2dcbc051a14a5131
https://doi.org/10.1016/j.tetlet.2010.01.049
https://doi.org/10.1016/j.tetlet.2010.01.049
Publikováno v:
Journal of Neuroscience Methods. 184:129-135
Vibrotactile stimulation has been used successfully to activate the human somatosensory pathway in functional magnetic resonance imaging (fMRI) experiments. The design and characterization of these devices are of particular interest in frequency disc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff0078cdfad5bbd95bd2f1cc6e3ebe60
https://doi.org/10.1016/j.jneumeth.2009.07.018
https://doi.org/10.1016/j.jneumeth.2009.07.018
Autor:
Charles Alois Dvorak, Francisco Javier Lopez-Tapia, Xiaojun Huang, Brad Loe, Debra A. Cockayne, William L. Fitch, Scott Broadbent, Berger Jacob, Christine E. Brotherton-Pleiss, Keith A. M. Walker, Rebecca Suttmann, David L. Bourdet, Lee Edwin Lowrie, Shelley K. Gleason, Dov Nitzan, Paul J. Wagner, Jiang Zhu, Zhao Shu-Hai, Fernando Padilla, André Alker, Joanie Caroon, Deborah Phippard, Alam Jahangir, Pankaj D. Rege
Publikováno v:
Journal of medicinal chemistry. 58(21)
Identification of singleton P2X7 inhibitor 1 from HTS gave a pharmacophore that eventually turned into potential clinical candidates 17 and 19. During development, a number of issues were successfully addressed, such as metabolic stability, plasma st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e880f027ef8eadeaef6f8cc77b4f99c
https://pubmed.ncbi.nlm.nih.gov/26460788
https://pubmed.ncbi.nlm.nih.gov/26460788
Publikováno v:
Hum Brain Mapp
Functional magnetic resonance imaging (fMRI) is often used to enhance visualization and provide target localization during the planning phase of neurosurgical procedures. Although parametric maps have been used to identify areas of eloquent cortex su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f75d084dbcbbc1e3583b609a8a292b62
https://pubmed.ncbi.nlm.nih.gov/18537113
https://pubmed.ncbi.nlm.nih.gov/18537113
Publikováno v:
ISBI
Pre-operative neurosurgical planning often uses data from functional magnetic resonance imaging (fMRI) to identify areas of eloquent cortex, such as the primary and secondary somatosensory cortices, to be spared during surgery. However, the in-vivo v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b51a3f1c4e8e5517e56f0bf70d848619
https://doi.org/10.1109/isbi.2008.4541232
https://doi.org/10.1109/isbi.2008.4541232
Autor:
Francisco Lopez-Tapia, Keith A. M. Walker, Christine Brotherton-Pleiss, Joanie Caroon, Dov Nitzan, Lee Lowrie, Shelley Gleason, Shu-Hai Zhao, Jacob Berger, Debra Cockayne, Deborah Phippard, Rebecca Suttmann, William L. Fitch, David Bourdet, Pankaj Rege, Xiaojun Huang, Scott Broadbent, Charles Dvorak, Jiang Zhu, Paul Wagner
Publikováno v:
Journal of Medicinal Chemistry; Nov2015, Vol. 58 Issue 21, p8413-8426, 14p