Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Scott Bang"'
Autor:
William W. Feng, Scott Bang, Eric M. Takacs, Cora Day, Katherine J. Crawford, Ruba Al-Sheyab, Dara B. Almufarrej, Wendy Wells, Serguei Ilchenko, Takhar Kasumov, Ning Kon, Colleen M. Novak, Wei Gu, Manabu Kurokawa
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108405- (2023)
Summary: Non-alcoholic fatty liver disease (NAFLD) is the most pervasive liver pathology worldwide. Here, we demonstrate that the ubiquitin E3 ligase Huwe1 is vital in NAFLD pathogenesis. Using mass spectrometry and RNA sequencing, we reveal that liv
Externí odkaz:
https://doaj.org/article/9d5527d6678e48a18fd4a270775d7fb2
Autor:
Alaa A. Eisa, Scott Bang, Katherine J. Crawford, Emily M. Murphy, William W. Feng, Souvik Dey, Wendy Wells, Ning Kon, Wei Gu, Lisa M. Mehlmann, Srinivasan Vijayaraghavan, Manabu Kurokawa
Publikováno v:
iScience, Vol 23, Iss 9, Pp 101523- (2020)
Summary: HUWE1 is a HECT-domain ubiquitin E3 ligase expressed in various tissues. Although HUWE1 is known to promote degradation of the tumor suppressor p53, given a growing list of its substrates, in vivo functions of HUWE1 remain elusive. Here, we
Externí odkaz:
https://doaj.org/article/641aafdd9ee84fdaa7cd93a2aaed9b62
Publikováno v:
Molecular & Cellular Oncology, Vol 7, Iss 2 (2020)
Acquired resistance to anti-HER2 therapy is a significant clinical challenge in breast cancer. We recently discovered that during acquisition of resistance to HER2 inhibition, upregulation of the fatty acid transporter CD36 takes place, playing a key
Externí odkaz:
https://doaj.org/article/f0fd63e09bd140a8b541aec74ae394e5
Autor:
William W. Feng, Owen Wilkins, Scott Bang, Matthew Ung, Jiaqi Li, Jennifer An, Carmen del Genio, Kaleigh Canfield, James DiRenzo, Wendy Wells, Arti Gaur, R. Brooks Robey, Jessie Yanxiang Guo, Ryan L. Powles, Christos Sotiriou, Lajos Pusztai, Maria Febbraio, Chao Cheng, William B. Kinlaw, Manabu Kurokawa
Publikováno v:
Cell Reports, Vol 29, Iss 11, Pp 3405-3420.e5 (2019)
Summary: Although it is established that fatty acid (FA) synthesis supports anabolic growth in cancer, the role of exogenous FA uptake remains elusive. Here we show that, during acquisition of resistance to HER2 inhibition, metabolic rewiring of brea
Externí odkaz:
https://doaj.org/article/a14657a83c5e46c19bc58549304e0355
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 1, p 261 (2019)
The tumor suppressor p53 and its homologues, p63 and p73, play a pivotal role in the regulation of the DNA damage response, cellular homeostasis, development, aging, and metabolism. A number of mouse studies have shown that a genetic defect in the p5
Externí odkaz:
https://doaj.org/article/7cfc897b05c24518a386b2911ec3fdf4
Autor:
Zhizhou Yue, Payel Datta, Yao-Rong Zheng, Han Wang, Manabu Kurokawa, Morgan Stilgenbauer, Scott Bang, Travis Beach, Haihua Xiao, David J. Bowers
Publikováno v:
Dalton Transactions. 49:8107-8113
Cisplatin is a platinum-based chemotherapeutic agent widely used in the treatment of various solid tumors. However, a major challenge in the use of cisplatin and in the development of cisplatin derivatives, namely Pt(iv) prodrugs, is their premature
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4c0688555a35c5ee66a9206255be01c
https://doi.org/10.1039/d0dt01297a
https://doi.org/10.1039/d0dt01297a
Autor:
Ryan L Powles, Carmen del Genio, Kaleigh Canfield, Jiaqi Li, Scott Bang, James DiRenzo, Maria Febbraio, Wendy A. Wells, Owen M. Wilkins, Manabu Kurokawa, Brooks R.B. Robey, Jessie Yanxiang Guo, Lajos Pusztai, Arti B. Gaur, William W. Feng, Matthew Ung, Chao Cheng, Jennifer An, William B. Kinlaw, Christos Sotiriou
Publikováno v:
Cell Reports, Vol 29, Iss 11, Pp 3405-3420.e5 (2019)
Cell reports
Cell reports, 29 (11
Cell reports
Cell reports, 29 (11
SUMMARY Although it is established that fatty acid (FA) synthesis supports anabolic growth in cancer, the role of exogenous FA uptake remains elusive. Here we show that, during acquisition of resistance to HER2 inhibition, metabolic rewiring of breas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e988590c1d04aee277533ee0949d447
http://www.sciencedirect.com/science/article/pii/S2211124719314792
http://www.sciencedirect.com/science/article/pii/S2211124719314792
Publikováno v:
Mol Cell Oncol
Acquired resistance to anti-HER2 therapy is a significant clinical challenge in breast cancer. We recently discovered that during acquisition of resistance to HER2 inhibition, upregulation of the fatty acid transporter CD36 takes place, playing a key
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb95f2a06aa8791f7c633327910268e9
https://europepmc.org/articles/PMC7051136/
https://europepmc.org/articles/PMC7051136/
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 1, p 261 (2019)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
The tumor suppressor p53 and its homologues, p63 and p73, play a pivotal role in the regulation of the DNA damage response, cellular homeostasis, development, aging, and metabolism. A number of mouse studies have shown that a genetic defect in the p5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3628d37bfafa97f6fd813fb80e295cc
https://www.mdpi.com/1422-0067/21/1/261
https://www.mdpi.com/1422-0067/21/1/261
Publikováno v:
The FEBS journal. 287(10)
The HECT E3 ubiquitin ligase HUWE1 is required for a wide array of important functions in cell biology. Although HUWE1 is known to play a role in DNA damage signaling, the mechanism(s) that underlie this function remain elusive. HUWE1 regulates effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6502e6846a8901eebf0fc8302c7932c
https://pubmed.ncbi.nlm.nih.gov/31904911
https://pubmed.ncbi.nlm.nih.gov/31904911