Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Scott B. Hansen"'
Autor:
Zixuan Yuan, Mahmud Arif Pavel, Hao Wang, Jerome C. Kwachukwu, Sonia Mediouni, Joseph Anthony Jablonski, Kendall W. Nettles, Chakravarthy B. Reddy, Susana T. Valente, Scott B. Hansen
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Super-resolution microscopy in cultured cells is employed to dissect the effect of hydroxychloroquine (HCQ) at the plasma membrane and HCQ directly perturbs clustering of the SARS-CoV-2 receptor ACE2 with endocytic lipids and PIP2 clusters.
Externí odkaz:
https://doaj.org/article/da95971dabb642e6b3a7d25f3abd74e0
Autor:
Zixuan Yuan, Scott B. Hansen
Publikováno v:
Membranes, Vol 13, Iss 2, p 250 (2023)
Cholesterol and phosphatidyl inositol 4,5-bisphosphate (PIP2) are hydrophobic molecules that regulate protein function in the plasma membrane of all cells. In this review, we discuss how changes in cholesterol concentration cause nanoscopic (2 is bet
Externí odkaz:
https://doaj.org/article/309a41b5f0f640eb84f55119d012991b
Autor:
Zixuan Yuan, Mahmud Arif Pavel, Hao Wang, Jerome C. Kwachukwu, Sonia Mediouni, Joseph Anthony Jablonski, Kendall W. Nettles, Chakravarthy B. Reddy, Susana T. Valente, Scott B. Hansen
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/08b31c7e3eb849eb804d542603f68586
Publikováno v:
Cell Reports, Vol 20, Iss 6, Pp 1287-1294 (2017)
Lipid regulation of ion channels by low-abundance signaling lipids phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid (PA) has emerged as a central cellular mechanism for controlling ion channels and the excitability of nerves. A lack
Externí odkaz:
https://doaj.org/article/3b2d05653228457784817828d5ee5d80
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
Mechanosensation by biological membranes can be relayed by mechanical tension to ion channels. Here the authors show that phospholipase D (PLD) is activated by mechanical disruption of lipid rafts which allows PLD to mix with its substrate in the lip
Externí odkaz:
https://doaj.org/article/ef25fc0a4a2e402685b431a30b4dbb41
Autor:
Hao Wang, Joshua A. Kulas, Holden Higginbotham, Michael A. Kovacs, Heather A. Ferris, Scott B. Hansen
Neurodegeneration and its concomitant loss of cognitive function is associated with inflammation and an accumulation of lipids, in particular cholesterol. In the brain, cholesterol is made in astrocytes and transported to surrounding cells by apolipo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b75452935230c630304b91984e7242c4
https://doi.org/10.1101/2022.12.12.520161
https://doi.org/10.1101/2022.12.12.520161
Autor:
Scott B. Hansen, Zixuan Yuan
Publikováno v:
Cell Chemical Biology. 30:233-234
Autor:
Hao Wang, Zixuan Yuan, Mahmud Arif Pavel, Sonia Mediouni Jablonski, Joseph Jablonski, Robert Hobson, Susana Valente, Chakravarthy B. Reddy, Scott B. Hansen
Publikováno v:
Journal of Biological Chemistry. :104763
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Anesthetics are used every day in thousands of hospitals to induce loss of consciousness, yet scientists and the doctors who administer these compounds lack a molecular understanding for their action. The chemical properties of anestheti
Autor:
Zixuan, Yuan, Mahmud Arif, Pavel, Hao, Wang, Jerome C, Kwachukwu, Sonia, Mediouni, Joseph Anthony, Jablonski, Kendall W, Nettles, Chakravarthy B, Reddy, Susana T, Valente, Scott B, Hansen
Publikováno v:
Communications biology. 5(1)
Hydroxychloroquine (HCQ), a drug used to treat lupus and malaria, was proposed as a treatment for SARS-coronavirus-2 (SARS-CoV-2) infection, albeit with controversy. In vitro, HCQ effectively inhibits viral entry, but its use in the clinic has been h