Zobrazeno 1 - 10
of 173
pro vyhledávání: '"Scott B. Ficarro"'
Autor:
Zhengnian Li, Jie Jiang, Scott B. Ficarro, Tyler S. Beyett, Ciric To, Isidoro Tavares, Yingde Zhu, Jiaqi Li, Michael J. Eck, Pasi A. Jänne, Jarrod A. Marto, Tinghu Zhang, Jianwei Che, Nathanael S. Gray
Publikováno v:
ACS Central Science, Vol 10, Iss 6, Pp 1156-1166 (2024)
Externí odkaz:
https://doaj.org/article/d5c6dbf338584d8bbd4b0121b594a89f
Autor:
Wai Cheung Chan, Xiaoxi Liu, Robert S. Magin, Nicholas M. Girardi, Scott B. Ficarro, Wanyi Hu, Maria I. Tarazona Guzman, Cara A. Starnbach, Alejandra Felix, Guillaume Adelmant, Anthony C. Varca, Bin Hu, Ariana S. Bratt, Ethan DaSilva, Nathan J. Schauer, Isabella Jaen Maisonet, Emma K. Dolen, Anthony X. Ayala, Jarrod A. Marto, Sara J. Buhrlage
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Deubiquitinases (DUBs) are key signaling enzymes, many of which lack selective inhibitors. Chan et al. pair a DUB-focused covalent library to mass spectrometry activity-based protein profiling, leading to selective hits against 23 endogenous DUBs and
Externí odkaz:
https://doaj.org/article/d6b807ef0bbf47468c2c964d3363d37f
Autor:
Jekaterina Vohhodina, Liana J. Goehring, Ben Liu, Qing Kong, Vladimir V. Botchkarev Jr., Mai Huynh, Zhiqi Liu, Fieda O. Abderazzaq, Allison P. Clark, Scott B. Ficarro, Jarrod A. Marto, Elodie Hatchi, David M. Livingston
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
BRCA1-mediated resolution of R-loops has previously been described. Here the authors reveal a functional association of BRCA1 with TERRA RNA at telomeres, which develops in an R-loop-, and a cell cycle-dependent manner.
Externí odkaz:
https://doaj.org/article/111700d569e04bcc80c6ff1a6421e107
Publikováno v:
HardwareX, Vol 11, Iss , Pp e00305- (2022)
We describe a complete open-source hardware/software solution for high performance thermostatted peptide fraction collection to support mass spectrometry experiments with complex proteomes. The instrument is easy to assemble using parts readily avail
Externí odkaz:
https://doaj.org/article/6ff0c7ffc064484a8ca3e2db8e6a3289
Autor:
Anthony R. Soltis, Norman J. Kennedy, Xiaofeng Xin, Feng Zhou, Scott B. Ficarro, Yoon Sing Yap, Bryan J. Matthews, Douglas A. Lauffenburger, Forest M. White, Jarrod A. Marto, Roger J. Davis, Ernest Fraenkel
Publikováno v:
Cell Reports, Vol 21, Iss 11, Pp 3317-3328 (2017)
Obesity is a major human health crisis that promotes insulin resistance and, ultimately, type 2 diabetes. The molecular mechanisms that mediate this response occur across many highly complex biological regulatory levels that are incompletely understo
Externí odkaz:
https://doaj.org/article/e5eebe857cdb4e9ab9c12f38a092d85a
Autor:
Jing Zhou, An-Chi Tien, John A. Alberta, Scott B. Ficarro, Amelie Griveau, Yu Sun, Janhavee S. Deshpande, Joseph D. Card, Meghan Morgan-Smith, Wojciech Michowski, Rintaro Hashizume, C. David James, Keith L. Ligon, William D. Snider, Peter Sicinski, Jarrod A. Marto, David H. Rowitch, Charles D. Stiles
Publikováno v:
Cell Reports, Vol 18, Iss 13, Pp 3167-3177 (2017)
During development of the vertebrate CNS, the basic helix-loop-helix (bHLH) transcription factor Olig2 sustains replication competence of progenitor cells that give rise to neurons and oligodendrocytes. A pathological counterpart of this developmenta
Externí odkaz:
https://doaj.org/article/7fb9e82920cf40d1898b5c51de91b9b8
Autor:
Daqi Tu, Zehua Zhu, Alicia Y. Zhou, Cai-hong Yun, Kyung-Eun Lee, Angela V. Toms, Yiqun Li, Gavin P. Dunn, Edmond Chan, Tran Thai, Shenghong Yang, Scott B. Ficarro, Jarrod A. Marto, Hyesung Jeon, William C. Hahn, David A. Barbie, Michael J. Eck
Publikováno v:
Cell Reports, Vol 3, Iss 3, Pp 747-758 (2013)
Upon stimulation by pathogen-associated inflammatory signals, TANK-binding kinase 1 (TBK1) induces type I interferon expression and modulates nuclear factor κB (NF-κB) signaling. Here, we describe the 2.4 Å-resolution crystal structure of nearly f
Externí odkaz:
https://doaj.org/article/994a8e3a594e4cb5822df3147232d8d4
Publikováno v:
Proteomes, Vol 5, Iss 3, p 20 (2017)
Although not yet truly ‘comprehensive’, modern mass spectrometry-based experiments can generate quantitative data for a meaningful fraction of the human proteome. Importantly for large-scale protein expression analysis, robust data pipelines are
Externí odkaz:
https://doaj.org/article/a54a3fc2720f45279481ad8bd3ab8ff8
Autor:
Wenchao Lu, Mengyang Fan, Wenzhi Ji, Jason Tse, Inchul You, Scott B. Ficarro, Isidoro Tavares, Jianwei Che, Audrey Y. Kim, Xijun Zhu, Andrew Boghossian, Matthew G. Rees, Melissa M. Ronan, Jennifer A. Roth, Stephen M. Hinshaw, Behnam Nabet, Steven M. Corsello, Nicholas Kwiatkowski, Jarrod A. Marto, Tinghu Zhang, Nathanael S. Gray
Publikováno v:
J Med Chem
Transcriptional enhanced associate domain (TEAD) proteins together with their transcriptional coactivator yes-associated protein (YAP) and transcriptional coactivator with the PDZ-binding motif (TAZ) are important transcription factors and cofactors
Autor:
Wenchao Lu, Yao Liu, Yang Gao, Qixiang Geng, Deepak Gurbani, Lianbo Li, Scott B. Ficarro, Cynthia J. Meyer, Dhiraj Sinha, Inchul You, Jason Tse, Zhixiang He, Wenzhi Ji, Jianwei Che, Audrey Y. Kim, Tengteng Yu, Kenneth Wen, Kenneth C. Anderson, Jarrod A. Marto, Kenneth D. Westover, Tinghu Zhang, Nathanael S. Gray
Publikováno v:
Journal of Medicinal Chemistry. 66:3356-3371