Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Scott Alan Frank"'
Publikováno v:
Angew Chem Int Ed Engl
Herein we report an organocatalytic enantioselective functionalization of heterocyclic carboxaldehydes via the Pictet-Spengler reaction. Through careful pairing of novel squaramide and Bronsted acid catalysts, our method tolerates a breadth of hetero
Autor:
Alison Campbell Brewer, H. George Vandeveer, Scott Alan Frank, J. Craig Ruble, C. Richard Nevill
Publikováno v:
Organic Process Research & Development. 25:576-582
Direct asymmetric reductive amination represents an efficient means of converting ketones to α-chiral primary amines, but reported examples are very limited. We describe the development of two sets...
Autor:
Renee L. DesJarlais, Sebastian Salentin, Klavs F. Jensen, Tommi S. Jaakkola, Daniel J. Griffin, Daniel Rodriguez Greve, Li Xing, Richard I. Robinson, Justin S. Cisar, Xinjun Hou, Constantine Kreatsoulas, Jeffrey W. Johannes, Andrew Palmer, Christos A. Nicolaou, Juan C. Alvarez, Regina Barzilay, William H. Green, Thomas J. Struble, Connor W. Coley, Ola Engkvist, Brian R. Lahue, Milan Chytil, Scott P. Brown, Scott Alan Frank, Daniel J. Price, Georg Mogk, Miriam Mathea
Publikováno v:
Journal of Medicinal Chemistry
Artificial intelligence and machine learning have demonstrated their potential role in predictive chemistry and synthetic planning of small molecules; there are at least a few reports of companies employing in silico synthetic planning into their ove
Autor:
Matthew M. Bio, Hui Li, David Kouvchinov, Scott Alan Frank, Martin D. Johnson, Yuan-Qing Fang, Andrew M. Clausen, Mark S. Kerr, Ian T. Crouch, Jillian W. Sheeran
Publikováno v:
The Journal of organic chemistry. 87(4)
The ketone intermediate LSN647712 is a key synthetic intermediate for the drug substance lasmiditan manufacturing process. A three-step connected continuous flow process utilizing a Turbo Grignard reagent, N-methylpiperidin-4-ylmagnesium chloride, an
Autor:
Justin L. Burt, Brandon J. Reizman, Scott Alan Frank, Salvador García-Muñoz, Mark D. Argentine
Publikováno v:
Organic Process Research & Development. 23:1429-1441
Regulatory approval for drug substance (DS) starting materials (SMs) represents a significant milestone in the progression toward approval of the proposed DS manufacturing process. To objectively p...
Autor:
Rebecca L. Davis-Harrison, Alastair J. Florence, Jeremy Hinds, Scott Alan Frank, Frederik J.S. Doerr, Lee J. Burns, Becky Lee
Publikováno v:
Pharmaceutical Research
Purpose Spray drying plays an important role in the pharmaceutical industry for product development of sensitive bio-pharmaceutical formulations. Process design, implementation and optimisation require in-depth knowledge of process-product interactio
Autor:
Adam D. McFarland, Olivia Gowran, Marie Kissane, Scott A. May, Alison N. Campbell, Gordon R. Lambertus, Paul E. Sheehan, Shon Roland Pulley, Niall G. Kerrigan, Martin D. Johnson, Philip C. Hoffman, Timothy D. White, Eric D. Moher, Richard D. Spencer, Brian D. Haeberle, Aoife P. Corrigan, Scott Alan Frank, James R. Stout, D. Hurley, Regina R. Lynch, Jonas Y. Buser
Publikováno v:
Organic Process Research & Development. 20:1870-1898
The design, development, and scale up of a continuous iridium-catalyzed homogeneous high pressure reductive amination reaction to produce 6, the penultimate intermediate in Lilly’s CETP inhibitor evacetrapib, is described. The scope of this report
Autor:
Charles A. Alt, Jeremy T. Spitler, Sathish K. Boini, Eric D. Moher, Chad E. Hadden, Scott Alan Frank, Radhe K. Vaid
Publikováno v:
Synthesis. 46:2463-2470
A high-yielding five-step synthesis of the title compound, methyl 7,9-dimethyl-5-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carboxylate, starting from 2,4-dimethylaniline was developed. This synthesis involved N-alkylation of 2,4-dimethylaniline w
Autor:
Michael O. Frederick, Michael E. LeTourneau, K. Derek Berglund, Adler W. Edward, Scott Alan Frank, Charles A. Alt, Jeffrey Thomas Vicenzi
Publikováno v:
Organic Process Research & Development. 18:546-551
For the synthesis of cholesteryl ester transfer protein (CETP) inhibitor evacetrapib, a hydrogenative reductive amination was chosen to join the substituted cyclohexyl subunit to the benzazepine core. The addition of water, which suppressed undesired
Autor:
Jeffrey Thomas Vicenzi, Paul A. Stroud, Gregory A. Rener, Gregory A. Stephenson, Marie Kissane, Scott Alan Frank, Radhe K. Vaid, Sathish K. Boini, Charles A. Alt, Laura A. McKee, Christopher P. Ley
Publikováno v:
Tetrahedron Letters. 54:6587-6591
The identification and development of an aldehyde–bisulfite adduct as an isolable starting material in the synthesis of the CETP inhibitor Evacetrapib are described. The physical properties of the sodium and potassium analogs are compared, and the