Zobrazeno 1 - 10
of 566
pro vyhledávání: '"Scott A. Tomlins"'
Autor:
Udit Singhal, Srinivas Nallandhighal, Jeffrey J. Tosoian, Kevin Hu, Trinh M. Pham, Judith Stangl-Kremser, Chia-Jen Liu, Razeen Karim, Komal R. Plouffe, Todd M. Morgan, Marcin Cieslik, Roberta Lucianò, Shahrokh F. Shariat, Nadia Finocchio, Lucia Dambrosio, Claudio Doglioni, Arul M. Chinnaiyan, Scott A. Tomlins, Alberto Briganti, Ganesh S. Palapattu, Aaron M. Udager, Simpa S. Salami
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-9 (2024)
Abstract Localized prostate cancer is frequently composed of multiple spatially distinct tumors with significant inter- and intra-tumoral molecular heterogeneity. This genomic diversity gives rise to many competing clones that may drive the biologica
Externí odkaz:
https://doaj.org/article/62b4741b814f4ceeb89934d4333d96c5
Autor:
Scott A. Tomlins, Nickolay A. Khazanov, Benjamin J. Bulen, Daniel H. Hovelson, Melissa J. Shreve, Laura E. Lamb, Marc R. Matrana, Mark E. Burkard, Eddy Shih-Hsin Yang, William Jeffery Edenfield, E. Claire Dees, Adedayo A. Onitilo, Michael Thompson, Gary L. Buchschacher, Alan M. Miller, Alexander Menter, Benjamin Parsons, Timothy Wassenaar, Leon C. Hwang, J. Marie Suga, Robert Siegel, William Irvin, Suresh Nair, Jennifer N. Slim, Jamal Misleh, Jamil Khatri, Gregory Masters, Sachdev Thomas, Malek Safa, Daniel M. Anderson, Kat Kwiatkowski, Khalis Mitchell, Tina Hu-Seliger, Stephanie Drewery, Andrew Fischer, Komal Plouffe, Eric Czuprenski, Jennifer Hipp, Travis Reeder, Hana Vakil, D. Bryan Johnson, Daniel R. Rhodes
Publikováno v:
Communications Medicine, Vol 3, Iss 1, Pp 1-14 (2023)
Tomlins et al. develop an Immunotherapy Response Score (IRS) to predict clinical benefit from checkpoint inhibition across solid tumors. IRS integrates TMB and gene expression, is evaluable from FFPE material, and is predictive for real-world progres
Externí odkaz:
https://doaj.org/article/4592ab4c5780454fabd8956daa3f8f79
Autor:
Antonio Rodriguez-Calero, John Gallon, Dilara Akhoundova, Sina Maletti, Alison Ferguson, Joanna Cyrta, Ursula Amstutz, Andrea Garofoli, Viola Paradiso, Scott A. Tomlins, Ekkehard Hewer, Vera Genitsch, Achim Fleischmann, Erik Vassella, Elisabeth J. Rushing, Rainer Grobholz, Ingeborg Fischer, Wolfram Jochum, Gieri Cathomas, Adeboye O. Osunkoya, Lukas Bubendorf, Holger Moch, George Thalmann, Charlotte K. Y. Ng, Silke Gillessen, Salvatore Piscuoglio, Mark A. Rubin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
The diagnosis of prostate cancer brain metastasis (PCBM) has increased. Here, the authors investigate the landscape of somatic genetic alterations in brain metastases in a PCBM cohort of 51 patients with non-synchronous matched primary samples availa
Externí odkaz:
https://doaj.org/article/42966ddd44de4ed4a87861f3d4c3176c
Autor:
Andi K. Cani, Emily M. Dolce, Elizabeth P. Darga, Kevin Hu, Chia‐Jen Liu, Jackie Pierce, Kieran Bradbury, Elaine Kilgour, Kimberly Aung, Gaia Schiavon, Danielle Carroll, T. Hedley Carr, Teresa Klinowska, Justin Lindemann, Gayle Marshall, Vicky Rowlands, Elizabeth A. Harrington, J. Carl Barrett, Nitharsan Sathiyayogan, Christopher Morrow, Valeria Sero, Anne C. Armstrong, Richard Baird, Erika Hamilton, Seock‐Ah Im, Komal Jhaveri, Manish R. Patel, Caroline Dive, Scott A. Tomlins, Aaron M. Udager, Daniel F. Hayes, Costanza Paoletti
Publikováno v:
Molecular Oncology, Vol 16, Iss 10, Pp 1969-1985 (2022)
Nearly all estrogen receptor (ER)‐positive (POS) metastatic breast cancers become refractory to endocrine (ET) and other therapies, leading to lethal disease presumably due to evolving genomic alterations. Timely monitoring of the molecular events
Externí odkaz:
https://doaj.org/article/3982ed92674c47fd83894acff6f5a9d3
Autor:
Jeffrey J. Tosoian, Rodney L. Dunn, Yashar S. Niknafs, Anjan Saha, Randy A. Vince, Jr, Jennifer L. St. Sauver, Debra J. Jacobson, Michaela E. McGree, Javed Siddiqui, Jack Groskopf, Steven J. Jacobsen, Scott A. Tomlins, Lakshmi P. Kunju, Todd M. Morgan, Simpa S. Salami, John T. Wei, Arul M. Chinnaiyan, Aruna V. Sarma
Publikováno v:
European Urology Open Science, Vol 29, Iss , Pp 30-35 (2021)
Background: Serum prostate-specific antigen (PSA), used in prostate cancer screening, is nonspecific for cancer and is affected by age and prostate volume. More specific biomarkers could be more accurate for early detection of prostate cancer and red
Externí odkaz:
https://doaj.org/article/26c4855afa5048b6a3973d79f02797bd
Autor:
Stephanie L. Skala, Scott R. Owens, Hong Xiao, Kristy A. Bauman, Scott A. Tomlins, Arul M. Chinnaiyan, Lina Shao, Jeffrey M. Jentzen, David Gordon, Rohit Mehra
Publikováno v:
Urology Case Reports, Vol 9, Iss C, Pp 37-40 (2016)
Hepatic cirrhosis is commonly associated with hyperestrogenism. Previous studies have reported morphologic changes in benign and malignant prostate tissue exposed to estrogen or anti-androgens. To our knowledge, histopathologic features of prostatic
Externí odkaz:
https://doaj.org/article/98e33328340e4f358804eb2ca9f6def3
Autor:
Yuanyuan Qiao, Felix Y. Feng, Yugang Wang, Xuhong Cao, Sumin Han, Kari Wilder-Romans, Nora M. Navone, Christopher Logothetis, Russell S. Taichman, Evan T. Keller, Ganesh S. Palapattu, Ajjai S. Alva, David C. Smith, Scott A. Tomlins, Arul M. Chinnaiyan, Todd M. Morgan
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 18, Iss 1, Pp 1-9 (2016)
A recent phase III trial of the MET kinase inhibitor cabozantinib in men with castration-resistant prostate cancer (CRPC) failed to meet its primary survival end point; however, most men with CRPC have intact androgen receptor (AR) signaling. As prev
Externí odkaz:
https://doaj.org/article/7c7a8b837b734f808d3434c101ceeb82
Autor:
Daniel H. Hovelson, Andrew S. McDaniel, Andi K. Cani, Bryan Johnson, Kate Rhodes, Paul D. Williams, Santhoshi Bandla, Geoffrey Bien, Paul Choppa, Fiona Hyland, Rajesh Gottimukkala, Guoying Liu, Manimozhi Manivannan, Jeoffrey Schageman, Efren Ballesteros-Villagrana, Catherine S. Grasso, Michael J. Quist, Venkata Yadati, Anmol Amin, Javed Siddiqui, Bryan L. Betz, Karen E. Knudsen, Kathleen A. Cooney, Felix Y. Feng, Michael H. Roh, Peter S. Nelson, Chia-Jen Liu, David G. Beer, Peter Wyngaard, Arul M. Chinnaiyan, Seth Sadis, Daniel R. Rhodes, Scott A. Tomlins
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 17, Iss 4, Pp 385-399 (2015)
Next-generation sequencing (NGS) has enabled genome-wide personalized oncology efforts at centers and companies with the specialty expertise and infrastructure required to identify and prioritize actionable variants. Such approaches are not scalable,
Externí odkaz:
https://doaj.org/article/e35c27ad1bb744a8a1d6afe2cf1f770b
Autor:
Zachary B. Koloff, Daniel A. Hamstra, John T. Wei, Jeffrey S. Montgomery, Scott A. Tomlins, Angela J. Wu, Todd M. Morgan, Javed Siddiqui, Kellie Paich, Arul M. Chinnaiyan, Felix Y. Feng, Alon Z. Weizer, Lakshmi P. Kunju, Brent K. Hollenbeck, David C. Miller, Ganesh S. Palapattu, Rohit Mehra
Publikováno v:
Asian Journal of Urology, Vol 2, Iss 1, Pp 53-58 (2015)
Objective: To better evaluate tertiary Gleason pattern reporting and to evaluate the impact of tertiary Gleason pattern 5 (TP5) on prostate cancer pathological features and biochemical recurrence at our large single institution. Methods: We retrospec
Externí odkaz:
https://doaj.org/article/1b682d53d9d240a985b9df9f622f4c43
Autor:
Robert J. Lonigro, Catherine S. Grasso, Dan R. Robinson, Xiaojun Jing, Yi-Mi Wu, Xuhong Cao, Michael J. Quist, Scott A. Tomlins, Kenneth J. Pienta, Arul M. Chinnaiyan
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 13, Iss 11, Pp 1019-1025 (2011)
The research community at large is expending considerable resources to sequence the coding region of the genomes of tumors and other human diseases using targeted exome capture (i.e., “whole exome sequencing”). The primary goal of targeted exome
Externí odkaz:
https://doaj.org/article/e5ed6df39c3945ecb398f0e0d24bd0a3