Výsledky vyhledávání - "Scott A. Stuart"

Intermittent treatment of BRAF V600E melanoma cells delays resistance by adaptive resensitization to drug rechallenge

Autor: Andrew J. Kavran, Scott A. Stuart, Kristyn R. Hayashi, Joel M. Basken, Barbara J. Brandhuber, Natalie G. Ahn

Publikováno v: Proceedings of the National Academy of Sciences. 119

Significance Preclinical studies of metastatic melanoma treated with targeted therapeutics have suggested that alternating periods of treatment and withdrawal might delay the onset of resistance. This has been attributed to drug addiction, where cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e5d6da36ee88f4d1d62cb102063d27b4
https://doi.org/10.1073/pnas.2113535119

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A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells*

Autor: Thomas Lee, Nan Wang, Stephane Houel, Natalie G. Ahn, Scott A. Stuart, William M. Old

Publikováno v: Molecular & Cellular Proteomics. 14:1599-1615

Inhibitors of oncogenic B-RAF(V600E) and MKK1/2 have yielded remarkable responses in B-RAF(V600E)-positive melanoma patients. However, the efficacy of these inhibitors is limited by the inevitable onset of resistance. Despite the fact that these inhi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bace826f10dedd30d163def83cb5e2a
https://doi.org/10.1074/mcp.m114.047233

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Efficacy of yoga for depressed postpartum women: A randomized controlled trial

Autor: Scott A. Stuart, Rebecca L. Brock, Melissa M. Buttner, Michael W. O'Hara

Publikováno v: Complementary Therapies in Clinical Practice. 21:94-100

Background Up to 20% of women experience postpartum depression (PPD). PPD is associated with anxiety and poor health-related quality of life (HRQOL). Efficacious treatments are critical; many women with PPD prefer complementary therapies. Thus, the c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cedb74c3270ef99d0900aaf459a1e801
https://doi.org/10.1016/j.ctcp.2015.03.003

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Specificity of Phosphorylation Responses to Mitogen Activated Protein (MAP) Kinase Pathway Inhibitors in Melanoma Cells

Autor: Natalie G. Ahn, Christopher C. Ebmeier, Scott A. Stuart, Thomas Lee, Joel Basken, William M. Old, Andrew J. Kavran

Publikováno v: Molecularcellular proteomics : MCP. 17(4)

The BRAF-MKK1/2-ERK1/2 pathway is constitutively activated in response to oncogenic mutations of BRAF in many cancer types, including melanoma. Although small molecules that inhibit oncogenic BRAF and MAP kinase kinase (MKK)1/2 have been successful i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a43b0842e07906ab644c1f759c00c606
https://pubmed.ncbi.nlm.nih.gov/29255136

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