Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Scott A. Scarneo"'
Autor:
Scott A. Scarneo, Aaron P. Smith, Jacob Favret, Robert O’Connell, Joy Pickeral, Kelly W. Yang, Guido Ferrari, David R. Loiselle, Philip F. Hughes, Manjusha M. Kulkarni, Madhusudhana Gargesha, Bryan Scott, Debashish Roy, Barton F. Haynes, Jesse J. Kwiek, Timothy A. J. Haystead
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Heat shock protein 90 (Hsp90) maintains cellular proteostasis during stress and has been under investigation as a therapeutic target in cancer for over two decades. We and others have identified a membrane expressed form of Hsp90 (mHsp90) th
Externí odkaz:
https://doaj.org/article/7498fd35bf0d43599a354d885b957978
Autor:
Scott A. Scarneo, Liesl S. Eibschutz, Phillip J. Bendele, Kelly W. Yang, Juliane Totzke, Philip Hughes, David A. Fox, Timothy A. J. Haystead
Publikováno v:
Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-10 (2019)
Abstract Objectives To examine the ability of takinib, a selective transforming growth factor beta-activated kinase 1 (TAK1) inhibitor, to reduce the severity of murine type II collagen-induced arthritis (CIA), and to affect function of synovial cell
Externí odkaz:
https://doaj.org/article/835086178b884f1cb96bf9e14b761464
Publikováno v:
Open Biology, Vol 10, Iss 9 (2020)
Aberrant tumour necrosis factor (TNF) signalling is a hallmark of many inflammatory diseases including rheumatoid arthritis (RA), irritable bowel disease and lupus. Maladaptive TNF signalling can lead to hyper active downstream nuclear factor (NF)-κ
Externí odkaz:
https://doaj.org/article/7918009002fb43b486548a8d2e9d0652
Autor:
Swarna Bale, Priyanka Verma, Bharath Yalavarthi, Scott Arthur Scarneo, Philip Hughes, M. Asif Amin, Pei-Suen Tsou, Dinesh Khanna, Timothy A.J. Haystead, Swati Bhattacharyya, John Varga
Publikováno v:
JCI Insight, Vol 8, Iss 14 (2023)
Multiorgan fibrosis in systemic sclerosis (SSc) accounts for substantial mortality and lacks effective therapies. Lying at the crossroad of TGF-β and TLR signaling, TGF-β–activated kinase 1 (TAK1) might have a pathogenic role in SSc. We therefore
Externí odkaz:
https://doaj.org/article/b5bda06bbf254b1d930547a5f45e0f51
Autor:
Scott A. Scarneo, Andrea G. Nackley, Yaomin Wang, Timothy A.J. Haystead, Kelly W. Yang, Xin Zhang, Shin Hyung Kim, Philip F. Hughes, Jiegen Chen
Publikováno v:
Pain
Heat shock protein 90 (Hsp90) is a ubiquitously expressed integral cellular protein essential for regulating proteomic stress. Previous research has shown that Hsp90 regulates critical signaling pathways underlying chronic pain and inflammation. Rece
Autor:
Scott A. Scarneo, B. Scott, Guido Ferrari, Manjusha Kulkarni, Favret J, Joy Pickeral, Aaron P. Smith, Kelly W. Yang, Barton F. Haynes, Gargesha M, Roy D, Robert J. O'Connell, Philip F. Hughes, David R. Loiselle, Haystead Taj, Jesse J. Kwiek
Heat shock protein 90 (Hsp90) maintains cellular proteostasis during stress and has been under investigation as a therapeutic target in cancer for over two decades. We and others have identified an extracellularly expressed form of Hsp90, eHsp90, tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ef67f38a7b1c6bd91028cce12f057f7
https://doi.org/10.1101/2021.06.06.446823
https://doi.org/10.1101/2021.06.06.446823
Autor:
Scott A. Scarneo, Kenneth D. Westover, Timothy A.J. Haystead, Kelly W. Yang, David A. Carlson, Deepak Gurbani, X. Philip F. Hughes
Publikováno v:
J Biol Chem
Interleukin-1 receptor–associated kinase-1 (IRAK-1) and IRAK-4, as well as transforming growth factor β–activated kinase 1 (TAK1), are protein kinases essential for transducing inflammatory signals from interleukin receptors. IRAK family protein
Autor:
Liesl S. Eibschutz, David E. Carlson, David R. Loiselle, Scott A. Scarneo, Philip F. Hughes, Timothy A.J. Haystead, Antoine Mansourati, Juliane Totzke, Jose R. Roques
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Immune challenge of invading macrophages at sites of infection is associated with release of TNF, which triggers a local cytokine storm as part of the normal inflammatory response. Whereas this response maybe beneficial in fighting off infections, si