Zobrazeno 1 - 10 of 61 pro vyhledávání: '"Scott A. Rollins"'
1
Crizanlizumab for the Prevention of Pain Crises in Sickle Cell Disease
Autor: Marina Pereira Colella, Victor R. Gordeuk, Kenneth I. Ataga, Rodolfo D. Cançado, Russell P. Rother, Jennifer Knight-Madden, Joao Ricardo Friedrisch, Julie Kanter, Wally R. Smith, Jonathan W. Stocker, Troy H. Guthrie, Darla K. Liles, Abdullah Kutlar, Sandra Fátima Menosi Gualandro, Ofelia A. Alvarez, Scott A. Rollins
Publikováno v: New England Journal of Medicine. 376:429-439
The up-regulation of P-selectin in endothelial cells and platelets contributes to the cell-cell interactions that are involved in the pathogenesis of vaso-occlusion and sickle cell-related pain crises. The safety and efficacy of crizanlizumab, an ant
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e0acb405dccf37acaf2d0a8c032e3d
https://doi.org/10.1056/nejmoa1611770
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3
Ecological Assessment With Benthic Algae
Autor: R. Jan Stevenson, Scott L. Rollins
In this chapter, we describe the use of benthic algae to assess stream water quality. We begin with a brief review of the topic and provide a framework for conducting ecological assessments using benthic algae. Sampling procedures to evaluate periphy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9034148180a01bda848694b4b9d8ddf3
https://doi.org/10.1016/b978-0-12-813047-6.00015-2
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4
A framework for developing ecosystem-specific nutrient criteria: Integrating biological thresholds with predictive modeling
Autor: Sylvia Heaton, Sarah W. Holden, R. Jan Stevenson, Patricia A. Soranno, Eric Torng, Kendra Spence Cheruvelil, Scott L. Rollins
Publikováno v: Limnology and Oceanography. 53:773-787
We present a novel ecosystem-specific framework for developing nutrient criteria from biological thresholds and predictive modeling (BTPM) and an application of this framework to lakes in Michigan, U.S. The four main components for the BTPM framework
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d3028e24521552c83dcd64000f0341fe
https://doi.org/10.4319/lo.2008.53.2.0773
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5
Discovery and development of the complement inhibitor eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria
Autor: Russell P. Rother, Robert A. Brodsky, Leonard Bell, Scott A. Rollins, Christopher F. Mojcik
Publikováno v: Nature Biotechnology. 25:1256-1264
The complement system provides critical immunoprotective and immunoregulatory functions but uncontrolled complement activation can lead to severe pathology. In the rare hemolytic disease paroxysmal nocturnal hemoglobinuria (PNH), somatic mutations re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a593ddfd187c4b5161085e0d18147832
https://doi.org/10.1038/nbt1344
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6
Concerning the mechanism of pexelizumab's benefit in acute myocardial infarction
Autor: Judith S. Hochman, Wei-Ching Chang, Pierre Théroux, Christopher B. Granger, Paul W. Armstrong, W. Douglas Weaver, Thomas G. Todaro, Kenneth W. Mahaffey, Scott A. Rollins
Publikováno v: American Heart Journal. 151:787-790
Background The COMplement inhibition in Myocardial infarction treated with Angioplasty (COMMA) trial previously demonstrated an unexpected dose-dependent reduction in 90-day mortality after bolus/infusion of pexelizumab despite no reduction in the pr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cbcc4fa0b9459ffaaadf11bcf5a689f
https://doi.org/10.1016/j.ahj.2005.06.008
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7
Pharmacologic C5-Complement Suppression Reduces Blood Loss During On-Pump Cardiac Surgery
Autor: Kevin J. Malloy, Keith Allen, John C. Chen, Stanton K. Shernan, Robert W. Colman, Steven Boyce, S B S Jamie Eng, Arthur Wallace, Jane C.K. Fitch, Pexelizumab Study Investigators, Scott A. Rollins
Publikováno v: Journal of Cardiac Surgery. 20:35-41
Background: Inflammation contributes to morbidity following on-pump cardiac surgery. Complement activation during cardiopulmonary bypass has been associated with the postoperative bleeding and tissue injury. This study examines the pharmacology and i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e0a7bbc12332d1e07a2388fb9de8614
https://doi.org/10.1111/j.0886-0440.2005.200370.x
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9
Effect of Eculizumab on Hemolysis and Transfusion Requirements in Patients with Paroxysmal Nocturnal Hemoglobinuria
Autor: Judith C. W. Marsh, Matthew J. Cullen, Peter Hillmen, Russell P. Rother, Scott A. Rollins, Claire Hall, Stephen J. Richards, Michael P Bombara, Modupe O. Elebute, Christopher F. Mojcik, Beth E. Petro
Publikováno v: New England Journal of Medicine. 350:552-559
background Paroxysmal nocturnal hemoglobinuria (PNH) arises from a somatic mutation of the PIG-A gene in a hematopoietic stem cell and the subsequent production of blood cells with a deficiency of surface proteins that protect the cells against attac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19c7e37575a0da730c55fa3bc7c68896
https://doi.org/10.1056/nejmoa031688
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10
Immune parameters relevant to neural xenograft survival in the primate brain
Autor: C.G. van Horne, Terrence W. Deacon, Willis V. Burton, William L. Fodor, F. Cicchetti, Scott A. Rollins, Lauren C. Costantini, Ole Isacson
Publikováno v: Xenotransplantation. 10:41-49
The lack of supply and access to human tissue has prompted the development of xenotransplantation as a potential clinical modality for neural cell transplantation. The goal of the present study was to achieve a better understanding of the immune fact
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::74513f928210030d4bbbaed77cf485f7
https://doi.org/10.1034/j.1399-3089.2003.01130.x
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