Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Scott A. Robson"'
Autor:
Kerem Kahraman, Scott A. Robson, Oktay Göcenler, Cansu M. Yenici, Cansu D. Tozkoparan Ceylan, Jennifer M. Klein, Volker Dötsch, Emine Sonay Elgin, Arthur L. Haas, Joshua J. Ziarek, Çağdaş Dağ
Publikováno v:
ACS Omega, Vol 9, Iss 38, Pp 39564-39572 (2024)
Externí odkaz:
https://doaj.org/article/865a04cad64044a3a062a4ea67f4f590
Autor:
Fabian Bumbak, James B. Bower, Skylar C. Zemmer, Asuka Inoue, Miquel Pons, Juan Carlos Paniagua, Fei Yan, James Ford, Hongwei Wu, Scott A. Robson, Ross A. D. Bathgate, Daniel J. Scott, Paul R. Gooley, Joshua J. Ziarek
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract The neurotensin receptor 1 (NTS1) is a G protein-coupled receptor (GPCR) with promise as a drug target for the treatment of pain, schizophrenia, obesity, addiction, and various cancers. A detailed picture of the NTS1 structural landscape has
Externí odkaz:
https://doaj.org/article/acdea264c4e64456b3085202211dd251
Autor:
Fabian Bumbak, Miquel Pons, Asuka Inoue, Juan Carlos Paniagua, Fei Yan, Hongwei Wu, Scott A. Robson, Ross A.D. Bathgate, Daniel J. Scott, Paul R. Gooley, Joshua J. Ziarek
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 112015- (2023)
Summary: Nuclear magnetic resonance (NMR) studies have revealed that fast methyl sidechain dynamics can report on entropically-driven allostery. Yet, NMR applications have been largely limited to the super-microsecond motional regimes of G protein-co
Externí odkaz:
https://doaj.org/article/e832682210c9421aa7945f05bde3d419
Autor:
Paul W. Coote, Scott A. Robson, Abhinav Dubey, Andras Boeszoermenyi, Mengxia Zhao, Gerhard Wagner, Haribabu Arthanari
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Bloch–Siegert shifts prevent the accurate observation of resonance frequencies in NMR experiments. Here the authors present a method for homonuclear decoupling that avoids inducing Bloch–Siegert shifts and improves the sensitivity and resolution
Externí odkaz:
https://doaj.org/article/cbceedd19fe04e49a3cca526a7eddfc5
Autor:
Scott A. Robson, Koh Takeuchi, Andras Boeszoermenyi, Paul W. Coote, Abhinav Dubey, Sven Hyberts, Gerhard Wagner, Haribabu Arthanari
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Structure determination of large proteins by solution state NMR is challenging due to spectral overlap. Here the authors present a labeling strategy using 2-13C and 3-13C pyruvate as carbon source for E. coli, which increases the effective resolution
Externí odkaz:
https://doaj.org/article/e5ddb6cd608240a3921746ce12e443cd
Autor:
Kerem Kahraman, Scott A. Robson, Oktay Göcenler, Cansu D. Tozkoparan, Jennifer M. Klein, Cansu M. Yenici, Arthur L. Haas, Joshua J. Ziarek, Çağdaş Dağ
Interferon-stimulated gene-15 (ISG15) is an interferon-induced protein with two ubiquitin-like (Ubl) domains linked by a short peptide chain, and the conjugated protein of the ISGylation system. Similar to ubiquitin and other Ubls, ISG15 is ligated t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::287ea98425a14ca048b7801d871d3cc7
https://doi.org/10.1101/2023.04.13.536743
https://doi.org/10.1101/2023.04.13.536743
Autor:
Fabian Bumbak, Asuka Inoue, Miquel Pons, Juan Carlos Paniagua, Fei Yan, Hongwei Wu, Scott A. Robson, Ross A. D. Bathgate, Daniel J. Scott, Paul R. Gooley, Joshua J. Ziarek
The neurotensin receptor 1 (NTS1) is a G protein-coupled receptor (GPCR) with promise as a drug target for the treatment of pain, schizophrenia, obesity, addiction, and various cancers. A detailed picture of the NTS1structural landscape has been esta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b859b3e71c53d209e165bf57e03a6050
https://doi.org/10.1101/2022.11.25.517797
https://doi.org/10.1101/2022.11.25.517797
Publikováno v:
Protein Science. 31
Fluorine (sup19/supF) offers several distinct advantages for biomolecular nuclear magnetic resonance spectroscopy such as no background signal, 100% natural abundance, high sensitivity, and a large chemical shift range. Exogenous cysteine-reactivesup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85b34d7816c9420d80a85a2d7e0718f5
https://doi.org/10.1002/pro.4454
https://doi.org/10.1002/pro.4454
Autor:
Fabian Bumbak, Miquel Pons, Asuka Inoue, Juan Carlos Paniagua, Fei Yan, Hongwei Wu, Scott A. Robson, Ross A. D. Bathgate, Daniel J. Scott, Paul R. Gooley, Joshua J. Ziarek
SummaryUnlike many signaling proteins that function as binary switches between ‘on and off’ states, G protein-coupled receptors (GPCRs) exhibit basal activity that can be increased or decreased by numerous ligands. A given receptor can recognize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d24743dec7c7152f6502cf798988c762
https://doi.org/10.1101/2022.08.09.503369
https://doi.org/10.1101/2022.08.09.503369
Autor:
Austin D. Dixon, Asuka Inoue, Scott A. Robson, Kelly J. Culhane, Jonathan C. Trinidad, Sivaraj Sivaramakrishnan, Fabian Bumbak, Joshua J. Ziarek
Using a discrete, intracellular 19F-NMR probe on transmembrane helix 6 (TM6) of the Neurotensin receptor 1 (NTS1), we aim to understand how ligands and transducers modulate the receptor’s structural ensemble in solution. For apo NTS1, 19F-NMR spect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49f0ed22f04ecba4d48a9c7225131db4
https://doi.org/10.1101/2021.12.08.471782
https://doi.org/10.1101/2021.12.08.471782