Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Scott A. Reisman"'
Autor:
James H. Lewis, Michel Jadoul, Geoffrey A. Block, Melanie P. Chin, Deborah A. Ferguson, Angie Goldsberry, Colin J. Meyer, Megan O’Grady, Pablo E. Pergola, Scott A. Reisman, W. Christian Wigley, Glenn M. Chertow
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 1, Pp 299-309 (2021)
In a multinational placebo‐controlled phase III clinical trial in 2,185 patients with type 2 diabetes mellitus and stage 4 chronic kidney disease, treatment with the Nrf2 activator bardoxolone methyl increased estimated glomerular filtration rate,
Externí odkaz:
https://doaj.org/article/0e32c9fcb5b24234bd19f3834348413d
Autor:
Mohammad A. Aminzadeh, Scott A. Reisman, Nosratola D. Vaziri, Stan Shelkovnikov, Seyed H. Farzaneh, Mahyar Khazaeli, Colin J. Meyer
Publikováno v:
Redox Biology, Vol 1, Iss 1, Pp 527-531 (2013)
Chronic kidney disease (CKD) is associated with endothelial dysfunction and accelerated cardiovascular disease, which are largely driven by systemic oxidative stress and inflammation. Oxidative stress and inflammation in CKD are associated with and,
Externí odkaz:
https://doaj.org/article/dc630b628c744200a5c264eadbf81a35
Autor:
Megan O'Grady, Colin J. Meyer, Michel Jadoul, Scott A. Reisman, James H. Lewis, Pablo E. Pergola, Geoffrey A. Block, Angie Goldsberry, Glenn M. Chertow, Deborah A. Ferguson, W. Christian Wigley, Melanie P. Chin
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 1, Pp 299-309 (2021)
Clinical and translational science, Vol. 14, no. 1, p. 299-309 (2021)
Clinical and translational science, Vol. 14, no.1, p. 299-309 (2021)
Clinical and Translational Science
Clinical and translational science, Vol. 14, no. 1, p. 299-309 (2021)
Clinical and translational science, Vol. 14, no.1, p. 299-309 (2021)
Clinical and Translational Science
In a multinational placebo‐controlled phase III clinical trial in 2,185 patients with type 2 diabetes mellitus and stage 4 chronic kidney disease, treatment with the Nrf2 activator bardoxolone methyl increased estimated glomerular filtration rate,
Autor:
Keith W. Ward, Chun-Yue I. Lee, Sarabjit S Gahir, Mitsumasa Sakamoto, Scott A. Reisman, Joel W. Proksch
Publikováno v:
Drug Design, Development and Therapy. 13:1259-1270
Background Omaveloxolone is a synthetic oleanane triterpenoid that pharmacologically activates Nrf2, a master transcription factor that regulates genes with antioxidative, anti-inflammatory, and mitochondrial bioenergetic properties, and is being eva
Publikováno v:
Free Radic Res
Slc7a11 (xCT) and Slc3a1 (rBAT) are cystine uptake transporters that maintain intracellular concentrations of cysteine, the rate-limiting amino acid in glutathione synthesis. This study was conducted to first determine the tissue distribution of the
Publikováno v:
Journal of Biochemical and Molecular Toxicology. 34
Omaveloxolone is a potent activator of Nrf2, a master transcriptional regulator of a multitude of cytoprotective functions, including antioxidative, anti-inflammatory, and mitochondrial bioenergetic effects. Some of the most potent known effects of N
Autor:
Colin J. Meyer, Jhanelle E. Gray, Geoffrey T. Gibney, Joseph Markowitz, Mark D. McKee, Scott J. Antonia, Ben C. Creelan, Eric B. Haura, Dmitry I. Gabrilovich, Scott A. Reisman, Tawee Tanvetyanon, Joel W. Proksch, Charles C. Williams, Melanie P. Chin, Jeffrey S. Weber
Publikováno v:
OncoTargets and therapy
Ben C Creelan,1 Dmitry I Gabrilovich,2 Jhanelle E Gray,1 Charles C Williams,1 Tawee Tanvetyanon,1 Eric B Haura,1 Jeffrey S Weber,3 Geoffrey T Gibney,4 Joseph Markowitz,5 Joel W Proksch,6 Scott A Reisman,6 Mark D McKee,7 Melanie P Chin,6 Colin J Meyer
Autor:
Scott A, Reisman, Sarabjit S, Gahir, Chun-Yue I, Lee, Joel W, Proksch, Mitsumasa, Sakamoto, Keith W, Ward
Publikováno v:
Drug Design, Development and Therapy
Background Omaveloxolone is a synthetic oleanane triterpenoid that pharmacologically activates Nrf2, a master transcription factor that regulates genes with antioxidative, anti-inflammatory, and mitochondrial bioenergetic properties, and is being eva
Autor:
Hao Yan, Patricia Fernández-Llama, Robert H. Christenson, David R. Plowchalk, David K. Packham, Xiaofang Yu, David B. Kingsmore, He Zhang, Joachim H. Ix, Cristina Esteva-Font, Michael W. Steffes, Yi Fang, Samuel A. Silver, Lori A. Plum, Maurizio Postorino, Jade J. Wong-You-Cheong, Jonathan G. Fox, Ziv Harel, Francesco U.S. Mattace-Raso, Ying Hang, Scott A. Reisman, Colin J. Meyer, Sokratis Stoumpos, Thomas C. Dowling, Marisa Battistella, Julia B. Zella, Hui Zhang, Xiaoxiao Yang, Francesca Mallamaci, Elena Guillén-Gómez, Stephen L. Seliger, J.M. Díaz, José Ballarín, Emma Aitken, Tongqiang Liu, David G. Warnock, George L. Bakris, Robert M. Richardson, Luis Guirado, Matthew R. Weir, Nosratola D. Vaziri, C Facundo, Graziella D'Arrigo, Hector F. DeLuca, Claudia Torino, Megan O'Grady, Laurence S. Magder, Zhaohui Ni, Kathryn K. Stevens, Ayse L. Mindikoglu, Shaopeng Liu, Jan L.C.M. van Saase, Marc Clancy, Giovanni Tripepi, Jiaqi Qian, Melanie P. Chin, Druckerei Stückle, Xiaoqiang Ding, Wei Fang, Emily C. Charlesworth, Peter A. McCullough, Margaret Clagett-Dame, Carmine Zoccali, Satz Mengensatzproduktion, William R. Hutson, Keith W. Ward, Rocco Tripepi, Colin C. Geddes, Aiwu Lin, Elisabet Ars, Jeffrey Perl, Michael Potochoiba, Madhumathi Rao, Jieru Cai, Bingying Zhang, Jiaying Huang, Andrew G. Bostom, Peter G. Linde
Publikováno v:
American Journal of Nephrology. 39:I-VI
Publikováno v:
Archives of Dermatological Research. 306:447-454
RTA 408 is a member of the synthetic oleanane triterpenoid class of compounds known to potently activate the cytoprotective transcription factor Nrf2. Because skin is constantly exposed to external oxidative stress, such as that from ultraviolet radi