Výsledky vyhledávání - "Scott A. Laneman"

Large-scale synthesis of high purity 'Phos reagent' useful for oligonucleotide therapeutics

Autor: Siegmar Pulst, Ravi R. Gukathasan, Sivakumar Ratnam, Indranil Gupta, Yogesh S. Sanghvi, Anwar Chowdhury, Scott A. Laneman, Morteza Massoudipour

Publikováno v: Journal of Organometallic Chemistry. 690:2603-2607

A large-scale, cost-effective, and environmentally clean synthesis of high purity 2-cyanoethyl- N , N , N ′, N ′-tetraisopropylphosphorodiamidite (Phos reagent) has been accomplished on a commercial scale. Treatment of PCl 3 with diisopropylamine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::364bdbc35072a0f68f0ba1e78c7af1e5
https://doi.org/10.1016/j.jorganchem.2004.10.014

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The Synthesis of the High-Potency Sweetener, NC-00637. Part 1: The Synthesis of (S)-2-Methylhexanoic Acid

Autor: Diane E. Froen, Ben Zhi, Scott A. Laneman, David J. Ager, David P. Pantaleone, Indra Prakash, Scott Babler

Publikováno v: Organic Process Research & Development. 7:369-378

The synthesis of the high potency sweetener candidate NC-00637 (1) required large quantities of (S)-2-methylhexanoic acid (2). This acid was first prepared in small quantities by the use of chiral auxiliaries. For large quantities, resolution by clas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ac37ab6d9d3cebb8b28bd3176cfdcf44
https://doi.org/10.1021/op025616i

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Separating the Racemic and Meso Diastereomers of a Binucleating Tetraphosphine Ligand System through the Use of Nickel Chloride

Autor: Frank R. Fronczek, George G. Stanley, David A. Aubry, Scott A. Laneman

Publikováno v: Inorganic Chemistry. 40:5036-5041

The reaction of a 1:1 mixture of rac- and meso-et,ph-P4 (et,ph-P4 = (Et(2)PCH(2)CH(2))(Ph)PCH(2)P(Ph)CH(2)CH(2)PEt(2)) with 2 equiv of NiCl(2).6H(2)O in EtOH produces soluble rac-Ni(2)Cl(4)(et,ph-P4) and precipitates meso-Ni(2)Cl(4)(et,ph-P4), allowi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::969c26f051d7a26ebb489a40f166c9b4
https://doi.org/10.1021/ic010035f

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Preparation of racemic 2,3-diaminobutane and the resolution of its (2S,3S) enantiomer

Autor: Peter N. Fernando, Peter K. Yonan, Scott A. Laneman, Mike G. Scaros

Publikováno v: Tetrahedron: Asymmetry. 8:1501-1506

A three-step procedure for large scale preparation of pure racemic 2,3-diaminobutane from relatively inexpensive meso 2,3-butanediol is described. Also, an efficient method for the resolution of (S,S) 2,3-diaminobutane from the racemic mixture in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2d8667b4e7e63b3ea9a9b8bd0b6b9383
https://doi.org/10.1016/s0957-4166(97)00156-0

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Preparation and structural characterization of bis(acetylacetonato)ruthenium(II)-BINAP: an efficient route to an effective asymmetric hydrogenation catalyst precursor

Autor: Albert Sun-Chi Chan, Cynthia X. Day, Scott A Laneman

Publikováno v: Inorganica Chimica Acta. 228:159-163

A simple one-pot synthesis of Ru(acac)2(S-BINAP) in near quantitative yield was achieved by the reduction of Ru(acac)3 (acac = acetylacetonate) with activated Zn in the presence of S-2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (S-BINAP). The X-ra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b8dcafd5e6c4e9fb0b8f976ef593c496
https://doi.org/10.1016/0020-1693(94)04167-t

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Synthesis of chiral succinates via Pd(0) catalyzed carbonylation/asymmetric hydrogenation sequence

Autor: Melissa L. Reilly, David H. Ripin, Scott A. Laneman, Freskos John N

Publikováno v: Tetrahedron Letters. 35:835-838

We report a novel 4 step synthesis of chiral trisubstituted succinic acid derivatives utilizing carbonylation of a vinyl triflate followed by catalytic asymmetric hydrogenation to yield the title compounds.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::15cb3393108777db951b66bbfe0176b4
https://doi.org/10.1016/s0040-4039(00)75976-4

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